ID   3MGH_MYCLE              Reviewed;         214 AA.
AC   O05678; Q9CC32;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 2.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Putative 3-methyladenine DNA glycosylase {ECO:0000255|HAMAP-Rule:MF_00527};
DE            EC=3.2.2.- {ECO:0000255|HAMAP-Rule:MF_00527};
GN   OrderedLocusNames=ML1351; ORFNames=MLC1351.17c;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- SIMILARITY: Belongs to the DNA glycosylase MPG family.
CC       {ECO:0000255|HAMAP-Rule:MF_00527}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB08290.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; Z95117; CAB08290.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL583921; CAC31732.1; -; Genomic_DNA.
DR   PIR; A87078; A87078.
DR   RefSeq; NP_301965.1; NC_002677.1.
DR   AlphaFoldDB; O05678; -.
DR   SMR; O05678; -.
DR   STRING; 272631.ML1351; -.
DR   EnsemblBacteria; CAC31732; CAC31732; CAC31732.
DR   KEGG; mle:ML1351; -.
DR   PATRIC; fig|272631.5.peg.2501; -.
DR   Leproma; ML1351; -.
DR   eggNOG; COG2094; Bacteria.
DR   HOGENOM; CLU_060471_3_1_11; -.
DR   OMA; VEAYHHT; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0003905; F:alkylbase DNA N-glycosylase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR   CDD; cd00540; AAG; 1.
DR   Gene3D; 3.10.300.10; -; 1.
DR   HAMAP; MF_00527; 3MGH; 1.
DR   InterPro; IPR011034; Formyl_transferase-like_C_sf.
DR   InterPro; IPR003180; MPG.
DR   InterPro; IPR036995; MPG_sf.
DR   PANTHER; PTHR10429; PTHR10429; 1.
DR   Pfam; PF02245; Pur_DNA_glyco; 1.
DR   SUPFAM; SSF50486; SSF50486; 1.
DR   TIGRFAMs; TIGR00567; 3mg; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Hydrolase; Reference proteome.
FT   CHAIN           1..214
FT                   /note="Putative 3-methyladenine DNA glycosylase"
FT                   /id="PRO_0000100093"
SQ   SEQUENCE   214 AA;  22313 MW;  6F97A6F363468528 CRC64;
     MRSPRRCKIC AVSADQLVVD PVVAAHRLLG ATITGRGVCA IVVEVEAYGG VPDGPWPDAA
     AHSYHGRNDR NAVMFGPPGR LYTYCSHGIH VCANVSCGPD GTAAAVLIRA GALENGADVA
     RSRRGASVRT VALARGPGNL CSALGITMDD NGIDVFAADS PVTLVLNEAQ EAMSGPRVGI
     SHAADRPWRL WLPGRPEVST YRRSPRAPAP GASD