ID   FFSR_ASPFV              Reviewed;         612 AA.
AC   A0A7M4BDQ2;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   07-APR-2021, sequence version 1.
DT   03-AUG-2022, entry version 5.
DE   RecName: Full=Transcription factor ffsR {ECO:0000303|PubMed:32913332};
DE   AltName: Full=Cytochalasans biosynthesis cluster protein ffsR {ECO:0000303|PubMed:32913332};
GN   Name=ffsR {ECO:0000303|PubMed:32913332};
OS   Aspergillus flavipes.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=41900;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=CNL-338;
RX   PubMed=32913332; DOI=10.1038/s41429-020-00368-0;
RA   Heard S.C., Wu G., Winter J.M.;
RT   "Discovery and characterization of a cytochalasan biosynthetic cluster from
RT   the marine-derived fungus Aspergillus flavipes CNL-338.";
RL   J. Antibiot. 73:803-807(2020).
CC   -!- FUNCTION: Transcription factor that specifically regulates the
CC       expression of the gene cluster that mediates the biosynthesis of the
CC       cytotoxic leucine-containing cytochalasans, including aspochalasin C,
CC       aspochalasin E, TMC-169, flavichalasine F, aspergillin PZ, aspochalasin
CC       M and flavichalasine G. {ECO:0000269|PubMed:32913332}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; MT586757; QOG08942.1; -; Genomic_DNA.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..612
FT                   /note="Transcription factor ffsR"
FT                   /id="PRO_0000454530"
FT   DNA_BIND        28..60
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          73..130
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          154..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          451..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..130
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        173..191
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        198..221
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        456..470
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   612 AA;  65818 MW;  C50044A24062EADA CRC64;
     MDTLTAPTTQ SEQPPPPLTA SLSRRYACDR CRSHKLRCNR DLMTSTNSPC QRCRKARVKC
     TIGASIRVGL SPEELKNGEN VHRASPGRSA GSHRTASTPS NHAPRSHGRT FTPESAHQAP
     PYPSNRSMSG SMRLSPVPWL DMISFDGAQE LNFDGSTSGL PMGSHTNGSG PLHAPMGGST
     SSNTSSTFLD VRPPLHTPAS SKPQQEAWRT GDDSTDLRLL SQIPRTRGGG VTDPAAGLTQ
     QHPAGVTSSA PLVSHDHAFA PPQTSIISEP IPGDDLPAGG RPPTWFPARS RAGSTPSPTE
     LKDACIQKLS DLSASLMKDL DLIITCKTAS SFLFTPSDKT AAGYLFKTLD GSMTEDNAVA
     RMLYGSERFL DIIKLFNQLP SLPSSSLSMP AAAAAAAAAA SYGSTRPVDS DDAYYYSDLE
     DTGDIRSRNP TPEDRGNEQW SILQAYLGRA GQGPPMGPSQ GSSSRSTTTN CSSSFVEVQK
     PDVPSILVIL SCYTCLLKIY ETVFFVIQHV LECSPANPSG TTDIPHTVRD LNINGFFLQN
     HRTLQIKILI QVSTYMLDSI QKSLGTILSD SMFQALLKTL MKEEGCTITS QGEETGMQGV
     RDLIRRVEEM LA