FG17_DANRE
ID FG17_DANRE Reviewed; 215 AA.
AC Q6SJP8; B0V214; B0V215;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Fibroblast growth factor 17;
DE Short=FGF-17;
DE AltName: Full=Fibroblast growth factor 17b;
DE Short=FGF-17b;
DE Flags: Precursor;
GN Name=fgf17; Synonyms=fgf17b; ORFNames=si:ch211-237h13.2, zgc:101759;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAR20841.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo {ECO:0000269|PubMed:15196956};
RX PubMed=15196956; DOI=10.1016/j.ydbio.2004.03.032;
RA Cao Y., Zhao J., Sun Z., Zhao Z., Postlethwait J., Meng A.;
RT "fgf17b, a novel member of Fgf family, helps patterning zebrafish
RT embryos.";
RL Dev. Biol. 271:130-143(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Olfactory epithelium;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in dorsal-ventral embryonic patterning, by promoting
CC expression of bone morphogenetic protein (BMP) antagonists such as chd.
CC Also involved in anterior-posterior neural patterning and in mesoderm
CC induction. {ECO:0000269|PubMed:15196956}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O60258}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6SJP8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6SJP8-2; Sequence=VSP_034101;
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. Zygotic
CC expression occurs in two stages: late blastulation/early gastrulation
CC with greatest expression in the embryonic shield; and during
CC segmentation with expression in the somites and presomitic mesoderm.
CC {ECO:0000269|PubMed:15196956}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAQ15049.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY457142; AAR20841.1; -; mRNA.
DR EMBL; CR936370; CAQ15049.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CR936370; CAQ15050.1; -; Genomic_DNA.
DR EMBL; BC083269; AAH83269.1; -; mRNA.
DR RefSeq; NP_999973.1; NM_214808.1. [Q6SJP8-1]
DR RefSeq; XP_005172548.1; XM_005172491.3. [Q6SJP8-2]
DR AlphaFoldDB; Q6SJP8; -.
DR SMR; Q6SJP8; -.
DR STRING; 7955.ENSDARP00000033747; -.
DR PaxDb; Q6SJP8; -.
DR Ensembl; ENSDART00000168252; ENSDARP00000137629; ENSDARG00000102778. [Q6SJP8-1]
DR GeneID; 407737; -.
DR KEGG; dre:407737; -.
DR CTD; 8822; -.
DR ZFIN; ZDB-GENE-040621-1; fgf17.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000167390; -.
DR InParanoid; Q6SJP8; -.
DR OMA; LCCQTQV; -.
DR PhylomeDB; Q6SJP8; -.
DR TreeFam; TF331233; -.
DR Reactome; R-DRE-109704; PI3K Cascade.
DR Reactome; R-DRE-1257604; PIP3 activates AKT signaling.
DR Reactome; R-DRE-190322; FGFR4 ligand binding and activation.
DR Reactome; R-DRE-190371; FGFR3b ligand binding and activation.
DR Reactome; R-DRE-190372; FGFR3c ligand binding and activation.
DR Reactome; R-DRE-190373; FGFR1c ligand binding and activation.
DR Reactome; R-DRE-190375; FGFR2c ligand binding and activation.
DR Reactome; R-DRE-5654219; Phospholipase C-mediated cascade: FGFR1.
DR Reactome; R-DRE-5654221; Phospholipase C-mediated cascade, FGFR2.
DR Reactome; R-DRE-5654227; Phospholipase C-mediated cascade, FGFR3.
DR Reactome; R-DRE-5654228; Phospholipase C-mediated cascade, FGFR4.
DR Reactome; R-DRE-5654687; Downstream signaling of activated FGFR1.
DR Reactome; R-DRE-5654688; SHC-mediated cascade:FGFR1.
DR Reactome; R-DRE-5654689; PI-3K cascade:FGFR1.
DR Reactome; R-DRE-5654693; FRS-mediated FGFR1 signaling.
DR Reactome; R-DRE-5654695; PI-3K cascade:FGFR2.
DR Reactome; R-DRE-5654699; SHC-mediated cascade:FGFR2.
DR Reactome; R-DRE-5654700; FRS-mediated FGFR2 signaling.
DR Reactome; R-DRE-5654704; SHC-mediated cascade:FGFR3.
DR Reactome; R-DRE-5654706; FRS-mediated FGFR3 signaling.
DR Reactome; R-DRE-5654710; PI-3K cascade:FGFR3.
DR Reactome; R-DRE-5654712; FRS-mediated FGFR4 signaling.
DR Reactome; R-DRE-5654719; SHC-mediated cascade:FGFR4.
DR Reactome; R-DRE-5654720; PI-3K cascade:FGFR4.
DR Reactome; R-DRE-5654726; Negative regulation of FGFR1 signaling.
DR Reactome; R-DRE-5654727; Negative regulation of FGFR2 signaling.
DR Reactome; R-DRE-5654732; Negative regulation of FGFR3 signaling.
DR Reactome; R-DRE-5654733; Negative regulation of FGFR4 signaling.
DR Reactome; R-DRE-5658623; FGFRL1 modulation of FGFR1 signaling.
DR Reactome; R-DRE-5673001; RAF/MAP kinase cascade.
DR Reactome; R-DRE-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR SignaLink; Q6SJP8; -.
DR PRO; PR:Q6SJP8; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 8.
DR Bgee; ENSDARG00000102778; Expressed in yolk syncytial layer and 48 other tissues.
DR ExpressionAtlas; Q6SJP8; baseline.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0005105; F:type 1 fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0005111; F:type 2 fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007498; P:mesoderm development; IMP:UniProtKB.
DR GO; GO:0042664; P:negative regulation of endodermal cell fate specification; IGI:ZFIN.
DR GO; GO:0007399; P:nervous system development; IMP:UniProtKB.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028287; FGF17.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF71; PTHR11486:SF71; 1.
DR Pfam; PF00167; FGF; 1.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Developmental protein; Differentiation; Glycoprotein;
KW Growth factor; Mitogen; Neurogenesis; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..215
FT /note="Fibroblast growth factor 17"
FT /id="PRO_0000008989"
FT CARBOHYD 137
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 24..34
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_034101"
SQ SEQUENCE 215 AA; 25203 MW; 1E73BC8788A5AC7D CRC64;
MYGINQRYLY ISFHFFVVWC HAQGEKNHPS PNFKQYVREQ GSLTDQLSRR QVRVYQLYSR
TSGKHVQIRG HRVSATADDG NSYARLYVET DTFGSRVRIK GAESGRYLCM NRRGKLVGKP
NGRGRDCIFT EIVLENNYTA LENARHEGWF VAFTRKGRPI RASKTRQNQR EVHFIKRLHK
GPQPFPNAEQ PKHFEFISFP STRRAKRNRK HQTAS
