FGF10_RAT
ID FGF10_RAT Reviewed; 215 AA.
AC P70492;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Fibroblast growth factor 10;
DE Short=FGF-10;
DE Flags: Precursor;
GN Name=Fgf10;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar;
RX PubMed=8663172; DOI=10.1074/jbc.271.27.15918;
RA Yamasaki M., Miyake A., Tagashira S., Itoh N.;
RT "Structure and expression of the rat mRNA encoding a novel member of the
RT fibroblast growth factor family.";
RL J. Biol. Chem. 271:15918-15921(1996).
CC -!- FUNCTION: Plays an important role in the regulation of embryonic
CC development, cell proliferation and cell differentiation. Required for
CC normal branching morphogenesis. May play a role in wound healing.
CC -!- SUBUNIT: Interacts with FGFR1 and FGFR2. Interacts with FGFBP1 (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Preferentially expressed in the lung in adults.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; D79215; BAA11468.1; -; mRNA.
DR RefSeq; NP_037083.1; NM_012951.1.
DR AlphaFoldDB; P70492; -.
DR SMR; P70492; -.
DR STRING; 10116.ENSRNOP00000016485; -.
DR GlyGen; P70492; 2 sites.
DR PaxDb; P70492; -.
DR Ensembl; ENSRNOT00000016485; ENSRNOP00000016485; ENSRNOG00000012278.
DR GeneID; 25443; -.
DR KEGG; rno:25443; -.
DR CTD; 2255; -.
DR RGD; 2606; Fgf10.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000158907; -.
DR HOGENOM; CLU_081609_3_1_1; -.
DR InParanoid; P70492; -.
DR OMA; KWILTHG; -.
DR OrthoDB; 1340221at2759; -.
DR PhylomeDB; P70492; -.
DR TreeFam; TF317805; -.
DR Reactome; R-RNO-109704; PI3K Cascade.
DR Reactome; R-RNO-1257604; PIP3 activates AKT signaling.
DR Reactome; R-RNO-190370; FGFR1b ligand binding and activation.
DR Reactome; R-RNO-190377; FGFR2b ligand binding and activation.
DR Reactome; R-RNO-5654219; Phospholipase C-mediated cascade: FGFR1.
DR Reactome; R-RNO-5654221; Phospholipase C-mediated cascade, FGFR2.
DR Reactome; R-RNO-5654687; Downstream signaling of activated FGFR1.
DR Reactome; R-RNO-5654688; SHC-mediated cascade:FGFR1.
DR Reactome; R-RNO-5654689; PI-3K cascade:FGFR1.
DR Reactome; R-RNO-5654693; FRS-mediated FGFR1 signaling.
DR Reactome; R-RNO-5654695; PI-3K cascade:FGFR2.
DR Reactome; R-RNO-5654699; SHC-mediated cascade:FGFR2.
DR Reactome; R-RNO-5654700; FRS-mediated FGFR2 signaling.
DR Reactome; R-RNO-5654726; Negative regulation of FGFR1 signaling.
DR Reactome; R-RNO-5654727; Negative regulation of FGFR2 signaling.
DR Reactome; R-RNO-5658623; FGFRL1 modulation of FGFR1 signaling.
DR Reactome; R-RNO-5673001; RAF/MAP kinase cascade.
DR Reactome; R-RNO-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR PRO; PR:P70492; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Bgee; ENSRNOG00000012278; Expressed in pancreas and 14 other tissues.
DR Genevisible; P70492; RN.
DR GO; GO:0009986; C:cell surface; ISO:RGD.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; ISO:RGD.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0042056; F:chemoattractant activity; ISO:RGD.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; ISS:UniProtKB.
DR GO; GO:0008083; F:growth factor activity; ISO:RGD.
DR GO; GO:0008201; F:heparin binding; ISS:UniProtKB.
DR GO; GO:0005111; F:type 2 fibroblast growth factor receptor binding; ISO:RGD.
DR GO; GO:0031532; P:actin cytoskeleton reorganization; ISO:RGD.
DR GO; GO:0001525; P:angiogenesis; IEP:RGD.
DR GO; GO:0048645; P:animal organ formation; ISO:RGD.
DR GO; GO:0009887; P:animal organ morphogenesis; ISO:RGD.
DR GO; GO:0048514; P:blood vessel morphogenesis; ISO:RGD.
DR GO; GO:0001974; P:blood vessel remodeling; ISO:RGD.
DR GO; GO:0060667; P:branch elongation involved in salivary gland morphogenesis; ISO:RGD.
DR GO; GO:0060445; P:branching involved in salivary gland morphogenesis; ISO:RGD.
DR GO; GO:0048754; P:branching morphogenesis of an epithelial tube; ISO:RGD.
DR GO; GO:0060436; P:bronchiole morphogenesis; ISO:RGD.
DR GO; GO:0060449; P:bud elongation involved in lung branching; ISO:RGD.
DR GO; GO:0060447; P:bud outgrowth involved in lung branching; ISO:RGD.
DR GO; GO:0030154; P:cell differentiation; IEP:RGD.
DR GO; GO:0007267; P:cell-cell signaling; ISO:RGD.
DR GO; GO:0006935; P:chemotaxis; ISO:RGD.
DR GO; GO:0007368; P:determination of left/right symmetry; ISO:RGD.
DR GO; GO:0048565; P:digestive tract development; ISO:RGD.
DR GO; GO:0031076; P:embryonic camera-type eye development; ISO:RGD.
DR GO; GO:0048566; P:embryonic digestive tract development; ISO:RGD.
DR GO; GO:0048557; P:embryonic digestive tract morphogenesis; ISO:RGD.
DR GO; GO:0030538; P:embryonic genitalia morphogenesis; ISO:RGD.
DR GO; GO:0009880; P:embryonic pattern specification; ISO:RGD.
DR GO; GO:0001935; P:endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:0008544; P:epidermis development; ISO:RGD.
DR GO; GO:0048730; P:epidermis morphogenesis; ISO:RGD.
DR GO; GO:0030855; P:epithelial cell differentiation; ISO:RGD.
DR GO; GO:0050673; P:epithelial cell proliferation; ISO:RGD.
DR GO; GO:0060664; P:epithelial cell proliferation involved in salivary gland morphogenesis; ISO:RGD.
DR GO; GO:0060441; P:epithelial tube branching involved in lung morphogenesis; ISO:RGD.
DR GO; GO:0070371; P:ERK1 and ERK2 cascade; ISO:RGD.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; ISO:RGD.
DR GO; GO:0097192; P:extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR GO; GO:0048807; P:female genitalia morphogenesis; ISO:RGD.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0060595; P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification; ISO:RGD.
DR GO; GO:0048144; P:fibroblast proliferation; IEA:Ensembl.
DR GO; GO:0031069; P:hair follicle morphogenesis; ISO:RGD.
DR GO; GO:0070384; P:Harderian gland development; ISO:RGD.
DR GO; GO:0050930; P:induction of positive chemotaxis; ISO:RGD.
DR GO; GO:0042472; P:inner ear morphogenesis; ISO:RGD.
DR GO; GO:0043616; P:keratinocyte proliferation; IEA:Ensembl.
DR GO; GO:0032808; P:lacrimal gland development; ISO:RGD.
DR GO; GO:0060174; P:limb bud formation; ISO:RGD.
DR GO; GO:0060173; P:limb development; ISO:RGD.
DR GO; GO:0035108; P:limb morphogenesis; ISO:RGD.
DR GO; GO:0048286; P:lung alveolus development; ISO:RGD.
DR GO; GO:0030324; P:lung development; ISO:RGD.
DR GO; GO:0060428; P:lung epithelium development; ISO:RGD.
DR GO; GO:0060425; P:lung morphogenesis; ISO:RGD.
DR GO; GO:0061115; P:lung proximal/distal axis specification; ISO:RGD.
DR GO; GO:0060430; P:lung saccule development; ISO:RGD.
DR GO; GO:0048808; P:male genitalia morphogenesis; ISO:RGD.
DR GO; GO:0060615; P:mammary gland bud formation; ISO:RGD.
DR GO; GO:0060594; P:mammary gland specification; ISO:RGD.
DR GO; GO:0060915; P:mesenchymal cell differentiation involved in lung development; ISO:RGD.
DR GO; GO:0060496; P:mesenchymal-epithelial cell signaling involved in lung development; ISO:RGD.
DR GO; GO:0001823; P:mesonephros development; ISO:RGD.
DR GO; GO:0001656; P:metanephros development; ISO:RGD.
DR GO; GO:0003338; P:metanephros morphogenesis; ISO:RGD.
DR GO; GO:0042693; P:muscle cell fate commitment; ISO:RGD.
DR GO; GO:0045596; P:negative regulation of cell differentiation; ISO:RGD.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0030857; P:negative regulation of epithelial cell differentiation; IEA:Ensembl.
DR GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; ISO:RGD.
DR GO; GO:2000647; P:negative regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:0042475; P:odontogenesis of dentin-containing tooth; ISO:RGD.
DR GO; GO:0035265; P:organ growth; ISO:RGD.
DR GO; GO:0001759; P:organ induction; IDA:MGI.
DR GO; GO:0030916; P:otic vesicle formation; ISO:RGD.
DR GO; GO:0031016; P:pancreas development; ISO:RGD.
DR GO; GO:0021983; P:pituitary gland development; ISO:RGD.
DR GO; GO:0050918; P:positive chemotaxis; ISO:RGD.
DR GO; GO:0032781; P:positive regulation of ATP-dependent activity; ISO:RGD.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; ISO:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0045739; P:positive regulation of DNA repair; ISO:RGD.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:0010634; P:positive regulation of epithelial cell migration; ISO:RGD.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISO:RGD.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:RGD.
DR GO; GO:0048146; P:positive regulation of fibroblast proliferation; ISO:RGD.
DR GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; ISO:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0071338; P:positive regulation of hair follicle cell proliferation; ISO:RGD.
DR GO; GO:0051549; P:positive regulation of keratinocyte migration; ISO:RGD.
DR GO; GO:0010838; P:positive regulation of keratinocyte proliferation; ISO:RGD.
DR GO; GO:0050671; P:positive regulation of lymphocyte proliferation; ISO:RGD.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; ISO:RGD.
DR GO; GO:0045931; P:positive regulation of mitotic cell cycle; ISO:RGD.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; ISO:RGD.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISO:RGD.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; ISO:RGD.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0050677; P:positive regulation of urothelial cell proliferation; ISS:UniProtKB.
DR GO; GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; ISO:RGD.
DR GO; GO:0070352; P:positive regulation of white fat cell proliferation; ISO:RGD.
DR GO; GO:0030177; P:positive regulation of Wnt signaling pathway; ISO:RGD.
DR GO; GO:0060513; P:prostatic bud formation; ISO:RGD.
DR GO; GO:0034394; P:protein localization to cell surface; ISO:RGD.
DR GO; GO:0060019; P:radial glial cell differentiation; ISO:RGD.
DR GO; GO:0032925; P:regulation of activin receptor signaling pathway; ISO:RGD.
DR GO; GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; ISO:RGD.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; ISO:RGD.
DR GO; GO:0046877; P:regulation of saliva secretion; ISO:RGD.
DR GO; GO:0008589; P:regulation of smoothened signaling pathway; ISO:RGD.
DR GO; GO:0060541; P:respiratory system development; ISO:RGD.
DR GO; GO:0032355; P:response to estradiol; IEP:RGD.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
DR GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
DR GO; GO:0007431; P:salivary gland development; ISO:RGD.
DR GO; GO:0007435; P:salivary gland morphogenesis; ISO:RGD.
DR GO; GO:0061033; P:secretion by lung epithelial cell involved in lung growth; ISO:RGD.
DR GO; GO:0060879; P:semicircular canal fusion; ISO:RGD.
DR GO; GO:0048752; P:semicircular canal morphogenesis; ISO:RGD.
DR GO; GO:0051145; P:smooth muscle cell differentiation; ISO:RGD.
DR GO; GO:0035019; P:somatic stem cell population maintenance; ISO:RGD.
DR GO; GO:0048536; P:spleen development; ISO:RGD.
DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR GO; GO:0060661; P:submandibular salivary gland formation; ISO:RGD.
DR GO; GO:0070075; P:tear secretion; ISO:RGD.
DR GO; GO:0048538; P:thymus development; ISO:RGD.
DR GO; GO:0030878; P:thyroid gland development; ISO:RGD.
DR GO; GO:0042246; P:tissue regeneration; IEP:RGD.
DR GO; GO:0060510; P:type II pneumocyte differentiation; ISO:RGD.
DR GO; GO:0050674; P:urothelial cell proliferation; ISO:RGD.
DR GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0050872; P:white fat cell differentiation; ISO:RGD.
DR GO; GO:0070343; P:white fat cell proliferation; IEA:Ensembl.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0042060; P:wound healing; ISO:RGD.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028252; FGF10.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF21; PTHR11486:SF21; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..36
FT /evidence="ECO:0000255"
FT CHAIN 37..215
FT /note="Fibroblast growth factor 10"
FT /id="PRO_0000008983"
FT REGION 49..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 50
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 203
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 215 AA; 24029 MW; 93778EFA6FC0866A CRC64;
MWKWILTHCA SAFPHLPGCC CCFLLLFLVS SVPVTCQALG QDMVSPEATN SSSSSSSSSS
SSSFSSPSSA GRHVRSYNHL QGDVRWRKLF SFTKYFLKIE KNGKVSGTKK ENCPYSILEI
TSVEIGVVAV KAINSNYYLA MNKKGKLYGS KEFNNDCKLK ERIEENGYNT YASFNWQHNG
RQMYVALNGK GAPRRGQKTR RKNTSAHFLP MVVHS
