FGF11_HUMAN
ID FGF11_HUMAN Reviewed; 225 AA.
AC Q92914; Q2YDX8;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Fibroblast growth factor 11;
DE Short=FGF-11;
DE AltName: Full=Fibroblast growth factor homologous factor 3;
DE Short=FHF-3;
GN Name=FGF11; Synonyms=FHF3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Retina;
RX PubMed=8790420; DOI=10.1073/pnas.93.18.9850;
RA Smallwood P.M., Munoz-Sanjuan I., Tong P., Macke J.P., Hendry S.H.,
RA Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.;
RT "Fibroblast growth factor (FGF) homologous factors: new members of the FGF
RT family implicated in nervous system development.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Han C., Zhang B., Zhou Y., Peng X., Yuan J., Qiang B.;
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT GLY-163.
RG NIEHS SNPs program;
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probably involved in nervous system development and function.
CC -!- INTERACTION:
CC Q92914; Q6NT76: HMBOX1; NbExp=3; IntAct=EBI-11987787, EBI-2549423;
CC Q92914; P35268: RPL22; NbExp=3; IntAct=EBI-11987787, EBI-354533;
CC Q92914; Q96MF2: STAC3; NbExp=3; IntAct=EBI-11987787, EBI-745680;
CC Q92914; Q9NVV9: THAP1; NbExp=3; IntAct=EBI-11987787, EBI-741515;
CC -!- TISSUE SPECIFICITY: Nervous system.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC URL="http://egp.gs.washington.edu/data/fgf11/";
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DR EMBL; U66199; AAB18915.1; -; mRNA.
DR EMBL; AY049782; AAL15439.1; -; mRNA.
DR EMBL; AY094623; AAM11871.1; -; Genomic_DNA.
DR EMBL; BC032502; AAH32502.1; -; mRNA.
DR EMBL; BC108265; AAI08266.1; -; mRNA.
DR CCDS; CCDS11105.1; -.
DR RefSeq; NP_001290389.1; NM_001303460.1.
DR RefSeq; NP_004103.1; NM_004112.3.
DR AlphaFoldDB; Q92914; -.
DR SMR; Q92914; -.
DR BioGRID; 108547; 200.
DR IntAct; Q92914; 4.
DR STRING; 9606.ENSP00000293829; -.
DR PhosphoSitePlus; Q92914; -.
DR BioMuta; FGF11; -.
DR DMDM; 2494457; -.
DR EPD; Q92914; -.
DR MassIVE; Q92914; -.
DR PaxDb; Q92914; -.
DR PRIDE; Q92914; -.
DR ProteomicsDB; 75599; -.
DR Antibodypedia; 58774; 217 antibodies from 26 providers.
DR DNASU; 2256; -.
DR Ensembl; ENST00000293829.9; ENSP00000293829.4; ENSG00000161958.11.
DR Ensembl; ENST00000639021.2; ENSP00000491684.1; ENSG00000283903.2.
DR GeneID; 2256; -.
DR KEGG; hsa:2256; -.
DR MANE-Select; ENST00000293829.9; ENSP00000293829.4; NM_004112.4; NP_004103.1.
DR UCSC; uc002ggz.4; human.
DR CTD; 2256; -.
DR DisGeNET; 2256; -.
DR GeneCards; FGF11; -.
DR HGNC; HGNC:3667; FGF11.
DR HPA; ENSG00000161958; Tissue enhanced (adrenal).
DR MIM; 601514; gene.
DR neXtProt; NX_Q92914; -.
DR OpenTargets; ENSG00000161958; -.
DR PharmGKB; PA28107; -.
DR VEuPathDB; HostDB:ENSG00000161958; -.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000158058; -.
DR HOGENOM; CLU_081609_2_0_1; -.
DR InParanoid; Q92914; -.
DR OMA; CRSGRAW; -.
DR OrthoDB; 1192273at2759; -.
DR PhylomeDB; Q92914; -.
DR TreeFam; TF317805; -.
DR PathwayCommons; Q92914; -.
DR Reactome; R-HSA-5576892; Phase 0 - rapid depolarisation.
DR SignaLink; Q92914; -.
DR SIGNOR; Q92914; -.
DR BioGRID-ORCS; 2256; 11 hits in 1080 CRISPR screens.
DR ChiTaRS; FGF11; human.
DR GenomeRNAi; 2256; -.
DR Pharos; Q92914; Tbio.
DR PRO; PR:Q92914; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q92914; protein.
DR Bgee; ENSG00000161958; Expressed in lower esophagus mucosa and 93 other tissues.
DR ExpressionAtlas; Q92914; baseline and differential.
DR Genevisible; Q92914; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; TAS:ProtInc.
DR GO; GO:0017080; F:sodium channel regulator activity; IBA:GO_Central.
DR GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR GO; GO:1905150; P:regulation of voltage-gated sodium channel activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028253; FGF11.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF67; PTHR11486:SF67; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 1: Evidence at protein level;
KW Growth factor; Reference proteome.
FT CHAIN 1..225
FT /note="Fibroblast growth factor 11"
FT /id="PRO_0000147602"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 163
FT /note="R -> G"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_018886"
SQ SEQUENCE 225 AA; 25005 MW; 3176FF22053072DC CRC64;
MAALASSLIR QKREVREPGG SRPVSAQRRV CPRGTKSLCQ KQLLILLSKV RLCGGRPARP
DRGPEPQLKG IVTKLFCRQG FYLQANPDGS IQGTPEDTSS FTHFNLIPVG LRVVTIQSAK
LGHYMAMNAE GLLYSSPHFT AECRFKECVF ENYYVLYASA LYRQRRSGRA WYLGLDKEGQ
VMKGNRVKKT KAAAHFLPKL LEVAMYQEPS LHSVPEASPS SPPAP
