FGF11_MOUSE
ID FGF11_MOUSE Reviewed; 225 AA.
AC P70378; Q5F291;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Fibroblast growth factor 11;
DE Short=FGF-11;
DE AltName: Full=Fibroblast growth factor homologous factor 3;
DE Short=FHF-3;
GN Name=Fgf11; Synonyms=Fhf3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Eye;
RX PubMed=8790420; DOI=10.1073/pnas.93.18.9850;
RA Smallwood P.M., Munoz-Sanjuan I., Tong P., Macke J.P., Hendry S.H.,
RA Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.;
RT "Fibroblast growth factor (FGF) homologous factors: new members of the FGF
RT family implicated in nervous system development.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Probably involved in nervous system development and function.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Brain and eye, and in a segmental pattern of the
CC embryonic body wall. In adult olfactory bulb, hippocampus and most
CC concentrated in Purkinje cell layer of the cerebellum.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; U66203; AAB18919.1; -; mRNA.
DR EMBL; AL603707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS24911.1; -.
DR RefSeq; NP_001278033.1; NM_001291104.1.
DR RefSeq; NP_034328.1; NM_010198.2.
DR RefSeq; XP_011247026.1; XM_011248724.2.
DR AlphaFoldDB; P70378; -.
DR SMR; P70378; -.
DR STRING; 10090.ENSMUSP00000099645; -.
DR iPTMnet; P70378; -.
DR PhosphoSitePlus; P70378; -.
DR PaxDb; P70378; -.
DR PeptideAtlas; P70378; -.
DR PRIDE; P70378; -.
DR Antibodypedia; 58774; 217 antibodies from 26 providers.
DR DNASU; 14166; -.
DR Ensembl; ENSMUST00000102585; ENSMUSP00000099645; ENSMUSG00000042826.
DR GeneID; 14166; -.
DR KEGG; mmu:14166; -.
DR UCSC; uc007jrr.2; mouse.
DR CTD; 2256; -.
DR MGI; MGI:109167; Fgf11.
DR VEuPathDB; HostDB:ENSMUSG00000042826; -.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000158058; -.
DR HOGENOM; CLU_081609_2_0_1; -.
DR InParanoid; P70378; -.
DR OMA; CRSGRAW; -.
DR OrthoDB; 1192273at2759; -.
DR PhylomeDB; P70378; -.
DR TreeFam; TF317805; -.
DR Reactome; R-MMU-5576892; Phase 0 - rapid depolarisation.
DR BioGRID-ORCS; 14166; 2 hits in 74 CRISPR screens.
DR PRO; PR:P70378; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; P70378; protein.
DR Bgee; ENSMUSG00000042826; Expressed in retinal neural layer and 84 other tissues.
DR ExpressionAtlas; P70378; baseline and differential.
DR Genevisible; P70378; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0017080; F:sodium channel regulator activity; IBA:GO_Central.
DR GO; GO:1905150; P:regulation of voltage-gated sodium channel activity; IBA:GO_Central.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028253; FGF11.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF67; PTHR11486:SF67; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Growth factor; Nucleus; Reference proteome.
FT CHAIN 1..225
FT /note="Fibroblast growth factor 11"
FT /id="PRO_0000147603"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 225 AA; 25178 MW; F1F3E3FECEC6D441 CRC64;
MAALASSLIR QKREVREPGG SRPVSAQRRV CPRGTKSLCQ KQLLILLSKV RLCGGRPTRQ
DRGPEPQLKG IVTKLFCRQG FYLQANPDGS IQGTPEDTSS FTHFNLIPVG LRVVTIQSAK
LGHYMAMNAE GLLYSSPHFT AECRFKECVF ENYYVLYASA LYRQRRSGRA WYLGLDKEGR
VMKGNRVKKT KAAAHFVPKL LEVAMYREPS LHSVPETSPS SPPAH
