FGF12_RAT
ID FGF12_RAT Reviewed; 243 AA.
AC P61150; O35339; P70376; Q924B4; Q92912; Q93001;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Fibroblast growth factor 12;
DE Short=FGF-12;
DE AltName: Full=Fibroblast growth factor homologous factor 1;
DE Short=FHF-1;
GN Name=Fgf12; Synonyms=Fhf1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Itoh N.;
RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND INTERACTION WITH SCN9A.
RX PubMed=11376006; DOI=10.1074/jbc.m101606200;
RA Liu C.J., Dib-Hajj S.D., Waxman S.G.;
RT "Fibroblast growth factor homologous factor 1B binds to the C-terminus of
RT the tetrodotoxin-resistant sodium channel rNav1.9a (NaN).";
RL J. Biol. Chem. 276:18925-18933(2001).
CC -!- FUNCTION: Involved in nervous system development and function. Promote
CC neuronal excitability by elevating the voltage dependence of neuronal
CC sodium channel SCN8A fast inactivation. {ECO:0000250|UniProtKB:P61328}.
CC -!- SUBUNIT: Interacts with the C-terminal region of SCN9A.
CC {ECO:0000269|PubMed:11376006}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=Fhf1a;
CC IsoId=P61150-1; Sequence=Displayed;
CC Name=2; Synonyms=Fhf1b;
CC IsoId=P61150-2; Sequence=VSP_010224;
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB079374; BAB84568.1; -; mRNA.
DR EMBL; AF348446; AAK59870.1; -; mRNA.
DR RefSeq; NP_570827.1; NM_130814.1. [P61150-1]
DR RefSeq; XP_017453344.1; XM_017597855.1. [P61150-2]
DR AlphaFoldDB; P61150; -.
DR SMR; P61150; -.
DR CORUM; P61150; -.
DR STRING; 10116.ENSRNOP00000002650; -.
DR iPTMnet; P61150; -.
DR PhosphoSitePlus; P61150; -.
DR PaxDb; P61150; -.
DR PRIDE; P61150; -.
DR ABCD; P61150; 1 sequenced antibody.
DR Ensembl; ENSRNOT00000002650; ENSRNOP00000002650; ENSRNOG00000001931. [P61150-2]
DR GeneID; 170630; -.
DR KEGG; rno:170630; -.
DR UCSC; RGD:620163; rat. [P61150-1]
DR CTD; 2257; -.
DR RGD; 620163; Fgf12.
DR VEuPathDB; HostDB:ENSRNOG00000001931; -.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000155929; -.
DR HOGENOM; CLU_081609_2_0_1; -.
DR InParanoid; P61150; -.
DR OMA; MECKFKE; -.
DR OrthoDB; 1192273at2759; -.
DR PhylomeDB; P61150; -.
DR TreeFam; TF330751; -.
DR Reactome; R-RNO-5576892; Phase 0 - rapid depolarisation.
DR PRO; PR:P61150; -.
DR Proteomes; UP000002494; Chromosome 11.
DR Bgee; ENSRNOG00000001931; Expressed in cerebellum and 19 other tissues.
DR ExpressionAtlas; P61150; baseline and differential.
DR Genevisible; P61150; RN.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0017080; F:sodium channel regulator activity; IDA:BHF-UCL.
DR GO; GO:0044325; F:transmembrane transporter binding; IPI:BHF-UCL.
DR GO; GO:0008344; P:adult locomotory behavior; ISO:RGD.
DR GO; GO:0007268; P:chemical synaptic transmission; ISO:RGD.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:InterPro.
DR GO; GO:2001258; P:negative regulation of cation channel activity; IDA:RGD.
DR GO; GO:0050905; P:neuromuscular process; ISO:RGD.
DR GO; GO:0010765; P:positive regulation of sodium ion transport; ISO:RGD.
DR GO; GO:0003254; P:regulation of membrane depolarization; IDA:BHF-UCL.
DR GO; GO:0098908; P:regulation of neuronal action potential; ISS:UniProtKB.
DR GO; GO:1902305; P:regulation of sodium ion transmembrane transport; IDA:BHF-UCL.
DR GO; GO:2000649; P:regulation of sodium ion transmembrane transporter activity; IDA:BHF-UCL.
DR GO; GO:1905150; P:regulation of voltage-gated sodium channel activity; ISS:UniProtKB.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028254; FGF12.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF17; PTHR11486:SF17; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Growth factor; Nucleus; Reference proteome.
FT CHAIN 1..243
FT /note="Fibroblast growth factor 12"
FT /id="PRO_0000147606"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 11..38
FT /note="Bipartite nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 15..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..66
FT /note="MAAAIASSLIRQKRQARESNSDRVSASKRRSSPSKDGRSLCERHVLGVFSKV
FT RFCSGRKRPVRRRP -> MESK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11376006"
FT /id="VSP_010224"
SQ SEQUENCE 243 AA; 27399 MW; 773ED10B5BDD033C CRC64;
MAAAIASSLI RQKRQARESN SDRVSASKRR SSPSKDGRSL CERHVLGVFS KVRFCSGRKR
PVRRRPEPQL KGIVTRLFSQ QGYFLQMHPD GTIDGTKDEN SDYTLFNLIP VGLRVVAIQG
VKASLYVAMN GEGYLYSSDV FTPECKFKES VFENYYVIYS STLYRQQESG RAWFLGLNKE
GQIMKGNRVK KTKPSSHFVP KPIEVCMYRE PSLHEIGEKQ GRSRKSSGTP TMNGGKVVNQ
DST
