FGF13_XENLA
ID FGF13_XENLA Reviewed; 245 AA.
AC A6P7H6; A6P7H5; Q6DFL4;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Fibroblast growth factor 13;
DE Short=FGF-13;
DE Short=xFGF13;
GN Name=fgf13;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), DEVELOPMENTAL STAGE, AND
RP FUNCTION.
RX PubMed=17584734; DOI=10.1074/jbc.m704277200;
RA Nishimoto S., Nishida E.;
RT "Fibroblast growth factor 13 is essential for neural differentiation in
RT Xenopus early embryonic development.";
RL J. Biol. Chem. 282:24255-24261(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Ovary;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Microtubule-binding protein which directly binds tubulin and
CC is involved in both polymerization and stabilization of microtubules
CC (By similarity). Through its action on microtubules, may participate in
CC the refinement of axons by negatively regulating axonal and leading
CC processes branching (By similarity). Plays a crucial role in neuron
CC polarization and migration (By similarity). Regulates voltage-gated
CC sodium channels transport and function (By similarity). Required for
CC proper head development, it is involved in neural differentiation
CC through regulation of the mek5-erk5 pathway (PubMed:17584734).
CC {ECO:0000250|UniProtKB:P70377, ECO:0000269|PubMed:17584734}.
CC -!- SUBCELLULAR LOCATION: Cell projection, filopodium
CC {ECO:0000250|UniProtKB:P70377}. Cell projection, growth cone
CC {ECO:0000250|UniProtKB:P70377}. Cell projection, dendrite
CC {ECO:0000250|UniProtKB:P70377}. Cell membrane, sarcolemma
CC {ECO:0000250|UniProtKB:P70377}. Cytoplasm
CC {ECO:0000250|UniProtKB:P70377}. Note=Not secreted. Localizes to the
CC lateral membrane and intercalated disks of myocytes.
CC {ECO:0000250|UniProtKB:P70377}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=xFGF13-S;
CC IsoId=A6P7H6-1; Sequence=Displayed;
CC Name=2; Synonyms=xFGF13-V;
CC IsoId=A6P7H6-2; Sequence=VSP_044134;
CC Name=3; Synonyms=xFGF13-VY;
CC IsoId=A6P7H6-3; Sequence=VSP_044135;
CC -!- DEVELOPMENTAL STAGE: Expressed maternally. Zygotic expression is
CC observed at neurula and tailbud stages. Widely expressed in the
CC presumptive ectoderm during blastula, and in the dorsal structures
CC during neurula and tailbud stages. At tailbud stages, strongly
CC expressed in the ventral region of neural tube. Isoform 1 is expressed
CC weakly at neurula and strongly at tailbud stage. Isoform 2 and isoform
CC 3 are strongly expressed at the tailbud stage.
CC {ECO:0000269|PubMed:17584734}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; AB308062; BAF66271.1; -; mRNA.
DR EMBL; AB308063; BAF66272.1; -; mRNA.
DR EMBL; BC076721; AAH76721.1; -; mRNA.
DR RefSeq; NP_001086499.1; NM_001093030.1. [A6P7H6-3]
DR RefSeq; XP_018084451.1; XM_018228962.1. [A6P7H6-3]
DR RefSeq; XP_018084452.1; XM_018228963.1. [A6P7H6-3]
DR RefSeq; XP_018084453.1; XM_018228964.1. [A6P7H6-1]
DR RefSeq; XP_018084454.1; XM_018228965.1. [A6P7H6-2]
DR AlphaFoldDB; A6P7H6; -.
DR SMR; A6P7H6; -.
DR DNASU; 446334; -.
DR GeneID; 446334; -.
DR KEGG; xla:446334; -.
DR CTD; 446334; -.
DR Xenbase; XB-GENE-484336; fgf13.L.
DR OMA; LYPSEHF; -.
DR Proteomes; UP000186698; Chromosome 8L.
DR Bgee; 446334; Expressed in muscle tissue and 16 other tissues.
DR GO; GO:0030424; C:axon; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0030425; C:dendrite; ISS:UniProtKB.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0030175; C:filopodium; ISS:UniProtKB.
DR GO; GO:0030426; C:growth cone; ISS:UniProtKB.
DR GO; GO:0005874; C:microtubule; ISS:UniProtKB.
DR GO; GO:0043005; C:neuron projection; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0048487; F:beta-tubulin binding; ISS:UniProtKB.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; ISS:UniProtKB.
DR GO; GO:0017080; F:sodium channel regulator activity; ISS:UniProtKB.
DR GO; GO:0044325; F:transmembrane transporter binding; ISS:UniProtKB.
DR GO; GO:0045200; P:establishment of neuroblast polarity; ISS:UniProtKB.
DR GO; GO:0060322; P:head development; IMP:UniProtKB.
DR GO; GO:1904862; P:inhibitory synapse assembly; ISS:UniProtKB.
DR GO; GO:0046785; P:microtubule polymerization; ISS:UniProtKB.
DR GO; GO:0048671; P:negative regulation of collateral sprouting; ISS:UniProtKB.
DR GO; GO:0007026; P:negative regulation of microtubule depolymerization; ISS:UniProtKB.
DR GO; GO:0030182; P:neuron differentiation; IMP:UniProtKB.
DR GO; GO:0001764; P:neuron migration; ISS:UniProtKB.
DR GO; GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB.
DR GO; GO:0070376; P:regulation of ERK5 cascade; IMP:UniProtKB.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028279; FGF13.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF145; PTHR11486:SF145; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Cell projection; Cytoplasm; Membrane;
KW Microtubule; Neurogenesis; Reference proteome.
FT CHAIN 1..245
FT /note="Fibroblast growth factor 13"
FT /id="PRO_0000419209"
FT REGION 1..62
FT /note="Mediates targeting to the nucleus"
FT /evidence="ECO:0000250"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..62
FT /note="MAAAIASSLIRQKRQAREREKSNACKCVSSPSKSKGNCEKNKLNVFSRVKLF
FT GSKKRRRRRP -> MSGKVIKPKEEKDASK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17584734"
FT /id="VSP_044134"
FT VAR_SEQ 1..62
FT /note="MAAAIASSLIRQKRQAREREKSNACKCVSSPSKSKGNCEKNKLNVFSRVKLF
FT GSKKRRRRRP -> MSGKVIKPKEEKDASKVLDDAPPGTQEYIMLRQDSIQSADLKKKE
FT SPFRAKCHEIFCCPLKQVHLKEHTEPE (in isoform 3)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_044135"
SQ SEQUENCE 245 AA; 27519 MW; 88FBC2D43543E0FB CRC64;
MAAAIASSLI RQKRQARERE KSNACKCVSS PSKSKGNCEK NKLNVFSRVK LFGSKKRRRR
RPEPQLKGIV TKLYSRQGYH LQLQPDGTID GAKEEESSAT VFNLIPVGLR VVAIQGVQTK
LYLAMNSEGY LYTSEHFTPE CKFKESVFEN YYVTYSSMIY RQQHSGRSWF LGLNKEGEIM
KGNHVKKNKP AAHFLPKPLK VAMYKEPSLH DLTEFSRSGS GTPTKSRSVS GVLNGGKSMS
QNDST
