FGF14_MOUSE
ID FGF14_MOUSE Reviewed; 247 AA.
AC P70379; Q3KNZ6; Q8BST0; Q9JHL9;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 25-MAY-2022, entry version 154.
DE RecName: Full=Fibroblast growth factor 14;
DE Short=FGF-14;
DE AltName: Full=Fibroblast growth factor homologous factor 4;
DE Short=FHF-4;
GN Name=Fgf14; Synonyms=Fhf4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Eye;
RX PubMed=8790420; DOI=10.1073/pnas.93.18.9850;
RA Smallwood P.M., Munoz-Sanjuan I., Tong P., Macke J.P., Hendry S.H.,
RA Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.;
RT "Fibroblast growth factor (FGF) homologous factors: new members of the FGF
RT family implicated in nervous system development.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10786625; DOI=10.1016/s0167-4781(99)00217-1;
RA Yamamoto S., Mikami T., Konishi M., Itoh N.;
RT "Stage-specific expression of a novel isoform of mouse FGF-14 (FHF-4) in
RT spermatocytes.";
RL Biochim. Biophys. Acta 1490:121-124(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pituitary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probably involved in nervous system development and function.
CC -!- SUBUNIT: Interacts with SCN8A. {ECO:0000250|UniProtKB:Q92915}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=P70379-1; Sequence=Displayed;
CC Name=2; Synonyms=FGF-14C;
CC IsoId=P70379-2; Sequence=VSP_001530;
CC -!- TISSUE SPECIFICITY: Brain and testis; widely distributed in the
CC developing nervous system. In adult, high levels in the granular layer
CC of the cerebellum, less in hippocampus and olfactory bulb.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; U66204; AAB18920.1; -; mRNA.
DR EMBL; AB029498; BAA89483.1; -; mRNA.
DR EMBL; AK030616; BAC27049.1; -; mRNA.
DR EMBL; BC107003; AAI07004.1; -; mRNA.
DR RefSeq; NP_034331.2; NM_010201.4.
DR RefSeq; XP_011243254.1; XM_011244952.2. [P70379-2]
DR AlphaFoldDB; P70379; -.
DR SMR; P70379; -.
DR IntAct; P70379; 2.
DR STRING; 10090.ENSMUSP00000093185; -.
DR iPTMnet; P70379; -.
DR PhosphoSitePlus; P70379; -.
DR PaxDb; P70379; -.
DR PRIDE; P70379; -.
DR ProteomicsDB; 271572; -. [P70379-1]
DR ProteomicsDB; 271573; -. [P70379-2]
DR ABCD; P70379; 1 sequenced antibody.
DR DNASU; 14169; -.
DR GeneID; 14169; -.
DR KEGG; mmu:14169; -.
DR UCSC; uc007vbv.2; mouse. [P70379-1]
DR CTD; 2259; -.
DR MGI; MGI:109189; Fgf14.
DR eggNOG; KOG3885; Eukaryota.
DR InParanoid; P70379; -.
DR Reactome; R-MMU-5576892; Phase 0 - rapid depolarisation.
DR BioGRID-ORCS; 14169; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Fgf14; mouse.
DR PRO; PR:P70379; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P70379; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IDA:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0008083; F:growth factor activity; ISO:MGI.
DR GO; GO:0008201; F:heparin binding; ISO:MGI.
DR GO; GO:0017080; F:sodium channel regulator activity; IBA:GO_Central.
DR GO; GO:0008344; P:adult locomotory behavior; IGI:MGI.
DR GO; GO:0007268; P:chemical synaptic transmission; IGI:MGI.
DR GO; GO:0007254; P:JNK cascade; ISO:MGI.
DR GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR GO; GO:0050905; P:neuromuscular process; IGI:MGI.
DR GO; GO:1901843; P:positive regulation of high voltage-gated calcium channel activity; ISO:MGI.
DR GO; GO:0010765; P:positive regulation of sodium ion transport; IGI:MGI.
DR GO; GO:0060078; P:regulation of postsynaptic membrane potential; ISO:MGI.
DR GO; GO:0048167; P:regulation of synaptic plasticity; ISO:MGI.
DR GO; GO:1903421; P:regulation of synaptic vesicle recycling; ISO:MGI.
DR GO; GO:1905150; P:regulation of voltage-gated sodium channel activity; IBA:GO_Central.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028284; FGF14.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF18; PTHR11486:SF18; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Growth factor; Nucleus; Reference proteome.
FT CHAIN 1..247
FT /note="Fibroblast growth factor 14"
FT /id="PRO_0000147611"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..84
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_001530"
FT CONFLICT 40
FT /note="F -> C (in Ref. 3; BAC27049)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 247 AA; 27764 MW; 372C6FC0BDC72FDA CRC64;
MAAAIASGLI RQKRQAREQH WDRPSASRRR SSPSKNRGLF NGNLVDIFSK VRIFGLKKRR
LRRQDPQLKG IVTRLYCRQG YYLQMHPDGA LDGTKDDSTN STLFNLIPVG LRVVAIQGVK
TGLYIAMNGE GYLYPSELFT PECKFKESVF ENYYVIYSSM LYRQQESGRA WFLGLNKEGQ
VMKGNRVKKT KPAAHFLPKP LEVAMYREPS LHDVGETVPK AGVTPSKSTS ASAIMNGGKP
VNKCKTT
