ID   FGF14_RAT               Reviewed;         247 AA.
AC   Q8R5L7;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Fibroblast growth factor 14;
DE            Short=FGF-14;
GN   Name=Fgf14;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Itoh N.;
RT   "Rattus norvegicus FGF14 mRNA.";
RL   Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably involved in nervous system development and function.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SCN8A. {ECO:0000250|UniProtKB:Q92915}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC       {ECO:0000305}.
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DR   EMBL; AB079500; BAB84580.1; -; mRNA.
DR   RefSeq; NP_071559.2; NM_022223.2.
DR   AlphaFoldDB; Q8R5L7; -.
DR   SMR; Q8R5L7; -.
DR   STRING; 10116.ENSRNOP00000042838; -.
DR   PhosphoSitePlus; Q8R5L7; -.
DR   PaxDb; Q8R5L7; -.
DR   PRIDE; Q8R5L7; -.
DR   ABCD; Q8R5L7; 1 sequenced antibody.
DR   Ensembl; ENSRNOT00000041551; ENSRNOP00000042838; ENSRNOG00000009288.
DR   GeneID; 63851; -.
DR   KEGG; rno:63851; -.
DR   UCSC; RGD:620165; rat.
DR   CTD; 2259; -.
DR   RGD; 620165; Fgf14.
DR   eggNOG; KOG3885; Eukaryota.
DR   GeneTree; ENSGT00940000156984; -.
DR   HOGENOM; CLU_081609_2_0_1; -.
DR   InParanoid; Q8R5L7; -.
DR   OMA; XAMYREP; -.
DR   PhylomeDB; Q8R5L7; -.
DR   TreeFam; TF317805; -.
DR   Reactome; R-RNO-5576892; Phase 0 - rapid depolarisation.
DR   PRO; PR:Q8R5L7; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000009288; Expressed in cerebellum and 3 other tissues.
DR   Genevisible; Q8R5L7; RN.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; ISO:RGD.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0008083; F:growth factor activity; IDA:RGD.
DR   GO; GO:0017080; F:sodium channel regulator activity; IBA:GO_Central.
DR   GO; GO:0008344; P:adult locomotory behavior; ISO:RGD.
DR   GO; GO:0007268; P:chemical synaptic transmission; ISO:RGD.
DR   GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR   GO; GO:0050905; P:neuromuscular process; ISO:RGD.
DR   GO; GO:1901843; P:positive regulation of high voltage-gated calcium channel activity; IMP:MGI.
DR   GO; GO:0010765; P:positive regulation of sodium ion transport; ISO:RGD.
DR   GO; GO:0060078; P:regulation of postsynaptic membrane potential; IDA:MGI.
DR   GO; GO:0048167; P:regulation of synaptic plasticity; IMP:MGI.
DR   GO; GO:1903421; P:regulation of synaptic vesicle recycling; IMP:MGI.
DR   GO; GO:1905150; P:regulation of voltage-gated sodium channel activity; IBA:GO_Central.
DR   CDD; cd00058; FGF; 1.
DR   InterPro; IPR028284; FGF14.
DR   InterPro; IPR002209; Fibroblast_GF_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR11486; PTHR11486; 1.
DR   PANTHER; PTHR11486:SF18; PTHR11486:SF18; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00263; HBGFFGF.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   2: Evidence at transcript level;
KW   Growth factor; Nucleus; Reference proteome.
FT   CHAIN           1..247
FT                   /note="Fibroblast growth factor 14"
FT                   /id="PRO_0000147612"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          216..247
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..29
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        222..247
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   247 AA;  27720 MW;  427C3C760894996E CRC64;
     MAAAIASGLI RQKRQAREQH WDRPSASRRR SSPSKNRGLC NGNLVDIFSK VRIFGLKKRR
     LRRQDPQLKG IVTRLYCRQG YYLQMHPDGA LDGTKDDSTN STLFNLIPVG LRVVAIQGVK
     TGLYIAMNGE GYLYPSELFT PECKFKESVF ENYYVIYSSM LYRQQESGRA WFLGLNKEGQ
     VMKGNRVKKT KPAAHFLPKP LEVAMYREPS LHDVGETVPK AGVTPSKSTS ASAIMNGGKP
     VNKCKTT