ID   FGF16_DANRE             Reviewed;         203 AA.
AC   Q2HXK8;
DT   04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Fibroblast growth factor 16;
DE            Short=FGF16;
GN   Name=fgf16;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, FUNCTION, AND DISRUPTION
RP   PHENOTYPE.
RX   PubMed=16815307; DOI=10.1016/j.bbrc.2006.06.108;
RA   Nomura R., Kamei E., Hotta Y., Konishi M., Miyake A., Itoh N.;
RT   "Fgf16 is essential for pectoral fin bud formation in zebrafish.";
RL   Biochem. Biophys. Res. Commun. 347:340-346(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=25333065; DOI=10.1002/mgg3.81;
RA   Laurell T., Nilsson D., Hofmeister W., Lindstrand A., Ahituv N.,
RA   Vandermeer J., Amilon A., Anneren G., Arner M., Pettersson M., Jaentti N.,
RA   Rosberg H.E., Cattini P.A., Nordenskjoeld A., Maekitie O.,
RA   Grigelioniene G., Nordgren A.;
RT   "Identification of three novel FGF16 mutations in X-linked recessive fusion
RT   of the fourth and fifth metacarpals and possible correlation with heart
RT   disease.";
RL   Mol. Genet. Genomic Med. 2:402-411(2014).
CC   -!- FUNCTION: Plays a crucial role in pectoral fin bud outgrowth.
CC       {ECO:0000269|PubMed:16815307, ECO:0000269|PubMed:25333065}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O54769}.
CC   -!- DEVELOPMENTAL STAGE: Not clearly detected before 12 and 14 hpf. At 18
CC       and 24 hpf, detected in the otic vesicle, telencephalon, and caudal
CC       fin. At 30 and 36 hpf, expressed in the otic vesicle, caudal fin,
CC       branchial arch, pectoral fin bud, and pituitary gland.
CC       {ECO:0000269|PubMed:25333065}.
CC   -!- DISRUPTION PHENOTYPE: Fishes shown a severe reduction in the size of
CC       the pectoral fins. {ECO:0000269|PubMed:16815307,
CC       ECO:0000269|PubMed:25333065}.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC       {ECO:0000255|RuleBase:RU049442}.
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DR   EMBL; AB201764; BAE79360.1; -; mRNA.
DR   EMBL; CR855117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC163741; AAI63741.1; -; mRNA.
DR   EMBL; BC163752; AAI63752.1; -; mRNA.
DR   RefSeq; NP_001035497.1; NM_001040407.1.
DR   AlphaFoldDB; Q2HXK8; -.
DR   SMR; Q2HXK8; -.
DR   STRING; 7955.ENSDARP00000061927; -.
DR   PaxDb; Q2HXK8; -.
DR   Ensembl; ENSDART00000061928; ENSDARP00000061927; ENSDARG00000042233.
DR   Ensembl; ENSDART00000190715; ENSDARP00000146424; ENSDARG00000110602.
DR   GeneID; 692065; -.
DR   KEGG; dre:692065; -.
DR   CTD; 8823; -.
DR   ZFIN; ZDB-GENE-060427-3; fgf16.
DR   eggNOG; KOG3885; Eukaryota.
DR   GeneTree; ENSGT00940000160087; -.
DR   HOGENOM; CLU_081609_0_0_1; -.
DR   InParanoid; Q2HXK8; -.
DR   OMA; TERYYYV; -.
DR   OrthoDB; 1097566at2759; -.
DR   PhylomeDB; Q2HXK8; -.
DR   TreeFam; TF317805; -.
DR   Reactome; R-DRE-109704; PI3K Cascade.
DR   Reactome; R-DRE-1257604; PIP3 activates AKT signaling.
DR   Reactome; R-DRE-190322; FGFR4 ligand binding and activation.
DR   Reactome; R-DRE-190372; FGFR3c ligand binding and activation.
DR   Reactome; R-DRE-190375; FGFR2c ligand binding and activation.
DR   Reactome; R-DRE-5654221; Phospholipase C-mediated cascade, FGFR2.
DR   Reactome; R-DRE-5654227; Phospholipase C-mediated cascade, FGFR3.
DR   Reactome; R-DRE-5654228; Phospholipase C-mediated cascade, FGFR4.
DR   Reactome; R-DRE-5654695; PI-3K cascade:FGFR2.
DR   Reactome; R-DRE-5654699; SHC-mediated cascade:FGFR2.
DR   Reactome; R-DRE-5654700; FRS-mediated FGFR2 signaling.
DR   Reactome; R-DRE-5654704; SHC-mediated cascade:FGFR3.
DR   Reactome; R-DRE-5654706; FRS-mediated FGFR3 signaling.
DR   Reactome; R-DRE-5654710; PI-3K cascade:FGFR3.
DR   Reactome; R-DRE-5654712; FRS-mediated FGFR4 signaling.
DR   Reactome; R-DRE-5654719; SHC-mediated cascade:FGFR4.
DR   Reactome; R-DRE-5654720; PI-3K cascade:FGFR4.
DR   Reactome; R-DRE-5654727; Negative regulation of FGFR2 signaling.
DR   Reactome; R-DRE-5654732; Negative regulation of FGFR3 signaling.
DR   Reactome; R-DRE-5654733; Negative regulation of FGFR4 signaling.
DR   Reactome; R-DRE-5673001; RAF/MAP kinase cascade.
DR   Reactome; R-DRE-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR   PRO; PR:Q2HXK8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 14.
DR   Bgee; ENSDARG00000042233; Expressed in larva.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0008283; P:cell population proliferation; IMP:ZFIN.
DR   GO; GO:0021846; P:cell proliferation in forebrain; IMP:ZFIN.
DR   GO; GO:0033278; P:cell proliferation in midbrain; IMP:ZFIN.
DR   GO; GO:0021536; P:diencephalon development; IMP:ZFIN.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0030900; P:forebrain development; IMP:ZFIN.
DR   GO; GO:0097154; P:GABAergic neuron differentiation; IMP:ZFIN.
DR   GO; GO:0048709; P:oligodendrocyte differentiation; IMP:ZFIN.
DR   GO; GO:0033339; P:pectoral fin development; IMP:ZFIN.
DR   GO; GO:0035138; P:pectoral fin morphogenesis; IMP:ZFIN.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:2000546; P:positive regulation of endothelial cell chemotaxis to fibroblast growth factor; IBA:GO_Central.
DR   GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR   GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR   GO; GO:0021544; P:subpallium development; IMP:ZFIN.
DR   CDD; cd00058; FGF; 1.
DR   InterPro; IPR028285; FGF16.
DR   InterPro; IPR002209; Fibroblast_GF_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR11486; PTHR11486; 1.
DR   PANTHER; PTHR11486:SF27; PTHR11486:SF27; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00263; HBGFFGF.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   2: Evidence at transcript level;
KW   Growth factor; Reference proteome; Secreted.
FT   CHAIN           1..203
FT                   /note="Fibroblast growth factor 16"
FT                   /id="PRO_0000431903"
SQ   SEQUENCE   203 AA;  23065 MW;  DA763C5521B66AA6 CRC64;
     MAEVAGFLGS IDLDLQAFPA LGNVPLSDGL NERLGLIEGR LQRGSLTDFG HLKGILRRRQ
     LYCRTGFQLE IFPNGTVHGT RQDHSRFGIL EFISLAVGLV SIRGVDAGLY LGMNEKGELY
     GSKKLTAECV FREQFEENWY NTYASTLFKH ADTGRYYYVA LNKDGSPREG SRTKKHQKLT
     HFLPRPVEIE KIPQAYRELF QHR