FGF17_RAT
ID FGF17_RAT Reviewed; 216 AA.
AC P63076; O70627;
DT 13-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Fibroblast growth factor 17;
DE Short=FGF-17;
DE Flags: Precursor;
GN Name=Fgf17;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=Wistar; TISSUE=Embryo;
RX PubMed=9514906; DOI=10.1006/bbrc.1998.8239;
RA Hoshikawa M., Ohbayashi N., Yonamine A., Konishi M., Ozaki K., Fukui S.,
RA Itoh N.;
RT "Structure and expression of a novel fibroblast growth factor, FGF-17,
RT preferentially expressed in the embryonic brain.";
RL Biochem. Biophys. Res. Commun. 244:187-191(1998).
CC -!- FUNCTION: Plays an important role in the regulation of embryonic
CC development and as signaling molecule in the induction and patterning
CC of the embryonic brain. Required for normal brain development.
CC -!- SUBUNIT: Interacts with FGFR3 and FGFR4. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9514906}.
CC -!- TISSUE SPECIFICITY: Expressed in embryonic brain, mostly in the isthmus
CC cerebellar neuroepithelium and septum neuroepithelium, and in all adult
CC tissues. {ECO:0000269|PubMed:9514906}.
CC -!- DEVELOPMENTAL STAGE: Expressed at high level in the brain embryo at
CC E14.5. Expressed at lower level in the brain embryo at E10.5 and E19.5.
CC {ECO:0000269|PubMed:9514906}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; AB008682; BAA25426.1; -; mRNA.
DR PIR; JC5972; JC5972.
DR RefSeq; NP_062071.1; NM_019198.1.
DR AlphaFoldDB; P63076; -.
DR SMR; P63076; -.
DR STRING; 10116.ENSRNOP00000017723; -.
DR GlyGen; P63076; 1 site.
DR PhosphoSitePlus; P63076; -.
DR PaxDb; P63076; -.
DR PRIDE; P63076; -.
DR Ensembl; ENSRNOT00000017723; ENSRNOP00000017723; ENSRNOG00000012912.
DR GeneID; 29368; -.
DR KEGG; rno:29368; -.
DR UCSC; RGD:2607; rat.
DR CTD; 8822; -.
DR RGD; 2607; Fgf17.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000161965; -.
DR HOGENOM; CLU_090682_0_0_1; -.
DR InParanoid; P63076; -.
DR OMA; LCCQTQV; -.
DR OrthoDB; 1190450at2759; -.
DR PhylomeDB; P63076; -.
DR TreeFam; TF331233; -.
DR Reactome; R-RNO-109704; PI3K Cascade.
DR Reactome; R-RNO-1257604; PIP3 activates AKT signaling.
DR Reactome; R-RNO-190322; FGFR4 ligand binding and activation.
DR Reactome; R-RNO-190371; FGFR3b ligand binding and activation.
DR Reactome; R-RNO-190372; FGFR3c ligand binding and activation.
DR Reactome; R-RNO-190373; FGFR1c ligand binding and activation.
DR Reactome; R-RNO-190375; FGFR2c ligand binding and activation.
DR Reactome; R-RNO-5654219; Phospholipase C-mediated cascade: FGFR1.
DR Reactome; R-RNO-5654221; Phospholipase C-mediated cascade, FGFR2.
DR Reactome; R-RNO-5654227; Phospholipase C-mediated cascade, FGFR3.
DR Reactome; R-RNO-5654228; Phospholipase C-mediated cascade, FGFR4.
DR Reactome; R-RNO-5654687; Downstream signaling of activated FGFR1.
DR Reactome; R-RNO-5654688; SHC-mediated cascade:FGFR1.
DR Reactome; R-RNO-5654689; PI-3K cascade:FGFR1.
DR Reactome; R-RNO-5654693; FRS-mediated FGFR1 signaling.
DR Reactome; R-RNO-5654695; PI-3K cascade:FGFR2.
DR Reactome; R-RNO-5654699; SHC-mediated cascade:FGFR2.
DR Reactome; R-RNO-5654700; FRS-mediated FGFR2 signaling.
DR Reactome; R-RNO-5654704; SHC-mediated cascade:FGFR3.
DR Reactome; R-RNO-5654706; FRS-mediated FGFR3 signaling.
DR Reactome; R-RNO-5654710; PI-3K cascade:FGFR3.
DR Reactome; R-RNO-5654712; FRS-mediated FGFR4 signaling.
DR Reactome; R-RNO-5654719; SHC-mediated cascade:FGFR4.
DR Reactome; R-RNO-5654720; PI-3K cascade:FGFR4.
DR Reactome; R-RNO-5654726; Negative regulation of FGFR1 signaling.
DR Reactome; R-RNO-5654727; Negative regulation of FGFR2 signaling.
DR Reactome; R-RNO-5654732; Negative regulation of FGFR3 signaling.
DR Reactome; R-RNO-5654733; Negative regulation of FGFR4 signaling.
DR Reactome; R-RNO-5658623; FGFRL1 modulation of FGFR1 signaling.
DR Reactome; R-RNO-5673001; RAF/MAP kinase cascade.
DR Reactome; R-RNO-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR PRO; PR:P63076; -.
DR Proteomes; UP000002494; Chromosome 15.
DR Genevisible; P63076; RN.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0005105; F:type 1 fibroblast growth factor receptor binding; ISO:RGD.
DR GO; GO:0005111; F:type 2 fibroblast growth factor receptor binding; ISO:RGD.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; ISO:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028287; FGF17.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF71; PTHR11486:SF71; 1.
DR Pfam; PF00167; FGF; 1.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Glycoprotein; Growth factor; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..216
FT /note="Fibroblast growth factor 17"
FT /id="PRO_0000008987"
FT REGION 195..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 137
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 216 AA; 24924 MW; 2EE94BDF75220F4C CRC64;
MGAARLLPNL TLCLQLLILC CQTQGENHPS PNFNQYVRDQ GAMTDQLSRR QIREYQLYSR
TSGKHVQVTG RRISATAEDG NKFAKLIVET DTFGSRVRIK GAESEKYICM NKRGKLIGKP
SGKSKDCVFT EIVLENNYTA FQNARHEGWF MAFTRQGRPR QASRSRQNQR EAHFIKRLYQ
GQLPFPNHAE RQKQFEFVGS APTRRTKRTR RPQSQT
