ID   FGF18_BOVIN             Reviewed;         207 AA.
AC   Q0VCA0;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Fibroblast growth factor 18;
DE            Short=FGF-18;
DE   AltName: Full=zFGF5;
DE   Flags: Precursor;
GN   Name=FGF18;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal lung;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the regulation of cell
CC       proliferation, cell differentiation and cell migration. Required for
CC       normal ossification and bone development. Stimulates hepatic and
CC       intestinal proliferation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with FGFR3 and FGFR4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC120280; AAI20281.1; -; mRNA.
DR   RefSeq; NP_001069475.1; NM_001076007.2.
DR   AlphaFoldDB; Q0VCA0; -.
DR   SMR; Q0VCA0; -.
DR   STRING; 9913.ENSBTAP00000000139; -.
DR   PaxDb; Q0VCA0; -.
DR   GeneID; 533929; -.
DR   KEGG; bta:533929; -.
DR   CTD; 8817; -.
DR   eggNOG; KOG3885; Eukaryota.
DR   InParanoid; Q0VCA0; -.
DR   OrthoDB; 1190450at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005104; F:fibroblast growth factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:InterPro.
DR   CDD; cd00058; FGF; 1.
DR   InterPro; IPR028289; FGF18.
DR   InterPro; IPR002209; Fibroblast_GF_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR11486; PTHR11486; 1.
DR   PANTHER; PTHR11486:SF4; PTHR11486:SF4; 1.
DR   Pfam; PF00167; FGF; 1.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Growth factor; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..207
FT                   /note="Fibroblast growth factor 18"
FT                   /id="PRO_0000279865"
FT   CARBOHYD        39
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        137
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        109..127
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   207 AA;  23951 MW;  C7FF22609DB699A8 CRC64;
     MYSAPSTCTC LCLHFLLLCF QVQVLAAEEN VDFRIHVENQ TRARDDVSRK QLRLYQLYSR
     TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK GKETEFYLCM NRKGKLVGKP
     DGTSKECVFI EKVLENNYTA LMSAKYSGWY VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK
     GQAELQKPFK YTTVTKRSRR IRPTHPG