FGF18_MOUSE
ID FGF18_MOUSE Reviewed; 207 AA.
AC O89101;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Fibroblast growth factor 18;
DE Short=FGF-18;
DE AltName: Full=zFGF5;
DE Flags: Precursor;
GN Name=Fgf18;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9742123; DOI=10.1128/mcb.18.10.6063;
RA Hu M.C.-T., Qiu W.R., Wang Y.-P., Hill D., Ring B.D., Scully S., Bolon B.,
RA Derose M., Luethy R., Simonet W.S., Arakawa T., Danilenko D.M.;
RT "FGF-18, a novel member of the fibroblast growth factor family, stimulates
RT hepatic and intestinal proliferation.";
RL Mol. Cell. Biol. 18:6063-6074(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo;
RX PubMed=9660775; DOI=10.1074/jbc.273.29.18161;
RA Ohbayashi N., Hoshikawa M., Kimura S., Yamasaki M., Fukui S., Ito N.;
RT "Structure and expression of the mRNA encoding a novel fibroblast growth
RT factor, FGF-18.";
RL J. Biol. Chem. 273:18161-18164(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Deisher T., Conklin D., Raymond F., Bukowski T., Holderman S., Hansen B.,
RA Sheppard P., O'Hara P.;
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an important role in the regulation of cell
CC proliferation, cell differentiation and cell migration. Required for
CC normal ossification and bone development. Stimulates hepatic and
CC intestinal proliferation (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with FGFR3 and FGFR4. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; AF075291; AAC62239.1; -; mRNA.
DR EMBL; AB004639; BAA31980.1; -; mRNA.
DR EMBL; AF211187; AAF22976.1; -; mRNA.
DR CCDS; CCDS24531.1; -.
DR RefSeq; NP_032031.1; NM_008005.2.
DR AlphaFoldDB; O89101; -.
DR SMR; O89101; -.
DR STRING; 10090.ENSMUSP00000020507; -.
DR GlyGen; O89101; 2 sites.
DR PhosphoSitePlus; O89101; -.
DR PaxDb; O89101; -.
DR PRIDE; O89101; -.
DR ProteomicsDB; 271576; -.
DR Antibodypedia; 16955; 235 antibodies from 30 providers.
DR DNASU; 14172; -.
DR Ensembl; ENSMUST00000020507; ENSMUSP00000020507; ENSMUSG00000057967.
DR GeneID; 14172; -.
DR KEGG; mmu:14172; -.
DR UCSC; uc007ikc.2; mouse.
DR CTD; 8817; -.
DR MGI; MGI:1277980; Fgf18.
DR VEuPathDB; HostDB:ENSMUSG00000057967; -.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000159553; -.
DR HOGENOM; CLU_090682_1_0_1; -.
DR InParanoid; O89101; -.
DR OMA; FRCIQML; -.
DR OrthoDB; 1190450at2759; -.
DR PhylomeDB; O89101; -.
DR TreeFam; TF331233; -.
DR Reactome; R-MMU-109704; PI3K Cascade.
DR Reactome; R-MMU-1257604; PIP3 activates AKT signaling.
DR Reactome; R-MMU-190322; FGFR4 ligand binding and activation.
DR Reactome; R-MMU-190371; FGFR3b ligand binding and activation.
DR Reactome; R-MMU-190372; FGFR3c ligand binding and activation.
DR Reactome; R-MMU-190375; FGFR2c ligand binding and activation.
DR Reactome; R-MMU-5654221; Phospholipase C-mediated cascade, FGFR2.
DR Reactome; R-MMU-5654227; Phospholipase C-mediated cascade, FGFR3.
DR Reactome; R-MMU-5654228; Phospholipase C-mediated cascade, FGFR4.
DR Reactome; R-MMU-5654695; PI-3K cascade:FGFR2.
DR Reactome; R-MMU-5654699; SHC-mediated cascade:FGFR2.
DR Reactome; R-MMU-5654700; FRS-mediated FGFR2 signaling.
DR Reactome; R-MMU-5654704; SHC-mediated cascade:FGFR3.
DR Reactome; R-MMU-5654706; FRS-mediated FGFR3 signaling.
DR Reactome; R-MMU-5654710; PI-3K cascade:FGFR3.
DR Reactome; R-MMU-5654712; FRS-mediated FGFR4 signaling.
DR Reactome; R-MMU-5654719; SHC-mediated cascade:FGFR4.
DR Reactome; R-MMU-5654720; PI-3K cascade:FGFR4.
DR Reactome; R-MMU-5654727; Negative regulation of FGFR2 signaling.
DR Reactome; R-MMU-5654732; Negative regulation of FGFR3 signaling.
DR Reactome; R-MMU-5654733; Negative regulation of FGFR4 signaling.
DR Reactome; R-MMU-5658623; FGFRL1 modulation of FGFR1 signaling.
DR Reactome; R-MMU-5673001; RAF/MAP kinase cascade.
DR Reactome; R-MMU-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR BioGRID-ORCS; 14172; 0 hits in 74 CRISPR screens.
DR PRO; PR:O89101; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; O89101; protein.
DR Bgee; ENSMUSG00000057967; Expressed in mesenchyme of tongue and 163 other tissues.
DR ExpressionAtlas; O89101; baseline and differential.
DR Genevisible; O89101; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0005105; F:type 1 fibroblast growth factor receptor binding; ISO:MGI.
DR GO; GO:0005111; F:type 2 fibroblast growth factor receptor binding; ISO:MGI.
DR GO; GO:0001525; P:angiogenesis; IMP:MGI.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0008283; P:cell population proliferation; IMP:MGI.
DR GO; GO:0002063; P:chondrocyte development; IMP:MGI.
DR GO; GO:0002062; P:chondrocyte differentiation; IGI:MGI.
DR GO; GO:0001958; P:endochondral ossification; IMP:MGI.
DR GO; GO:0070371; P:ERK1 and ERK2 cascade; IDA:MGI.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IGI:MGI.
DR GO; GO:0001957; P:intramembranous ossification; IMP:MGI.
DR GO; GO:0030324; P:lung development; IMP:MGI.
DR GO; GO:0007399; P:nervous system development; ISO:MGI.
DR GO; GO:0001503; P:ossification; IMP:MGI.
DR GO; GO:0045766; P:positive regulation of angiogenesis; ISO:MGI.
DR GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:MGI.
DR GO; GO:0032332; P:positive regulation of chondrocyte differentiation; IGI:MGI.
DR GO; GO:2000546; P:positive regulation of endothelial cell chemotaxis to fibroblast growth factor; ISO:MGI.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:2000347; P:positive regulation of hepatocyte proliferation; ISO:MGI.
DR GO; GO:0043406; P:positive regulation of MAP kinase activity; ISO:MGI.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; IMP:MGI.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; TAS:MGI.
DR GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IMP:MGI.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028289; FGF18.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF4; PTHR11486:SF4; 1.
DR Pfam; PF00167; FGF; 1.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Growth factor; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..207
FT /note="Fibroblast growth factor 18"
FT /id="PRO_0000008991"
FT CARBOHYD 39
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 137
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 109..127
FT /evidence="ECO:0000250"
SQ SEQUENCE 207 AA; 23921 MW; CD5F987B271628B8 CRC64;
MYSAPSACTC LCLHFLLLCF QVQVLAAEEN VDFRIHVENQ TRARDDVSRK QLRLYQLYSR
TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK GKETEFYLCM NRKGKLVGKP
DGTSKECVFI EKVLENNYTA LMSAKYSGWY VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK
GQAELQKPFK YTTVTKRSRR IRPTHPG
