ID   FGF18_RAT               Reviewed;         207 AA.
AC   O88182;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Fibroblast growth factor 18;
DE            Short=FGF-18;
DE   Flags: Precursor;
GN   Name=Fgf18;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Embryo;
RX   PubMed=9660775; DOI=10.1074/jbc.273.29.18161;
RA   Ohbayashi N., Hoshikawa M., Kimura S., Yamasaki M., Fukui S., Ito N.;
RT   "Structure and expression of the mRNA encoding a novel fibroblast growth
RT   factor, FGF-18.";
RL   J. Biol. Chem. 273:18161-18164(1998).
CC   -!- FUNCTION: Plays an important role in the regulation of cell
CC       proliferation, cell differentiation and cell migration. Required for
CC       normal ossification and bone development. Stimulates hepatic and
CC       intestinal proliferation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with FGFR3 and FGFR4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Mainly expressed in the lung. Not detected in
CC       brain, heart, liver, kidney and small intestine.
CC   -!- DEVELOPMENTAL STAGE: Expressed in several discrete regions at embryonic
CC       days 14.5 and 19.5 but not 10.5. At E14.5, expressed in isthmus,
CC       pituitary, spinal cord, tongue, intervertebral disk, dorsal root
CC       ganglion and pelvis. At E19.5, expressed in lung and anterior
CC       pituitary.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB004638; BAA31979.1; -; mRNA.
DR   RefSeq; NP_062072.1; NM_019199.1.
DR   AlphaFoldDB; O88182; -.
DR   SMR; O88182; -.
DR   STRING; 10116.ENSRNOP00000064983; -.
DR   GlyGen; O88182; 2 sites.
DR   PaxDb; O88182; -.
DR   PRIDE; O88182; -.
DR   Ensembl; ENSRNOT00000103123; ENSRNOP00000084264; ENSRNOG00000048389.
DR   GeneID; 29369; -.
DR   KEGG; rno:29369; -.
DR   CTD; 8817; -.
DR   RGD; 2608; Fgf18.
DR   eggNOG; KOG3885; Eukaryota.
DR   GeneTree; ENSGT00940000159553; -.
DR   InParanoid; O88182; -.
DR   OrthoDB; 1190450at2759; -.
DR   PhylomeDB; O88182; -.
DR   Reactome; R-RNO-109704; PI3K Cascade.
DR   Reactome; R-RNO-1257604; PIP3 activates AKT signaling.
DR   Reactome; R-RNO-190322; FGFR4 ligand binding and activation.
DR   Reactome; R-RNO-190371; FGFR3b ligand binding and activation.
DR   Reactome; R-RNO-190372; FGFR3c ligand binding and activation.
DR   Reactome; R-RNO-190375; FGFR2c ligand binding and activation.
DR   Reactome; R-RNO-5654221; Phospholipase C-mediated cascade, FGFR2.
DR   Reactome; R-RNO-5654227; Phospholipase C-mediated cascade, FGFR3.
DR   Reactome; R-RNO-5654228; Phospholipase C-mediated cascade, FGFR4.
DR   Reactome; R-RNO-5654695; PI-3K cascade:FGFR2.
DR   Reactome; R-RNO-5654699; SHC-mediated cascade:FGFR2.
DR   Reactome; R-RNO-5654700; FRS-mediated FGFR2 signaling.
DR   Reactome; R-RNO-5654704; SHC-mediated cascade:FGFR3.
DR   Reactome; R-RNO-5654706; FRS-mediated FGFR3 signaling.
DR   Reactome; R-RNO-5654710; PI-3K cascade:FGFR3.
DR   Reactome; R-RNO-5654712; FRS-mediated FGFR4 signaling.
DR   Reactome; R-RNO-5654719; SHC-mediated cascade:FGFR4.
DR   Reactome; R-RNO-5654720; PI-3K cascade:FGFR4.
DR   Reactome; R-RNO-5654727; Negative regulation of FGFR2 signaling.
DR   Reactome; R-RNO-5654732; Negative regulation of FGFR3 signaling.
DR   Reactome; R-RNO-5654733; Negative regulation of FGFR4 signaling.
DR   Reactome; R-RNO-5658623; FGFRL1 modulation of FGFR1 signaling.
DR   Reactome; R-RNO-5673001; RAF/MAP kinase cascade.
DR   Reactome; R-RNO-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR   PRO; PR:O88182; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0005105; F:type 1 fibroblast growth factor receptor binding; ISO:RGD.
DR   GO; GO:0005111; F:type 2 fibroblast growth factor receptor binding; ISO:RGD.
DR   GO; GO:0001525; P:angiogenesis; ISO:RGD.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0002063; P:chondrocyte development; ISO:RGD.
DR   GO; GO:0001958; P:endochondral ossification; ISO:RGD.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; ISO:RGD.
DR   GO; GO:0001957; P:intramembranous ossification; ISO:RGD.
DR   GO; GO:0030324; P:lung development; ISO:RGD.
DR   GO; GO:0007399; P:nervous system development; IMP:RGD.
DR   GO; GO:0001503; P:ossification; ISO:RGD.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; ISO:RGD.
DR   GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; ISO:RGD.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR   GO; GO:0032332; P:positive regulation of chondrocyte differentiation; ISO:RGD.
DR   GO; GO:2000546; P:positive regulation of endothelial cell chemotaxis to fibroblast growth factor; ISO:RGD.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:RGD.
DR   GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR   GO; GO:2000347; P:positive regulation of hepatocyte proliferation; IDA:UniProtKB.
DR   GO; GO:0043406; P:positive regulation of MAP kinase activity; ISO:RGD.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR   GO; GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; ISO:RGD.
DR   GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR   CDD; cd00058; FGF; 1.
DR   InterPro; IPR028289; FGF18.
DR   InterPro; IPR002209; Fibroblast_GF_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR11486; PTHR11486; 1.
DR   PANTHER; PTHR11486:SF4; PTHR11486:SF4; 1.
DR   Pfam; PF00167; FGF; 1.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Growth factor; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..207
FT                   /note="Fibroblast growth factor 18"
FT                   /id="PRO_0000008992"
FT   REGION          157..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        163..180
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        39
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        137
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        109..127
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   207 AA;  23951 MW;  D90EDD7B271628B8 CRC64;
     MYSAPSACTC LCLHFLLLCF QVQVLAAEEN VDFRIHVENQ TRARDDVSRK QLRLYQLYSR
     TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK GKETEFYLCM NRKGKLVGKP
     DGTSKECVFI EKVLENNYTA LMSAKYSGWY VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK
     GQTELQKPFK YTTVTKRSRR IRPTHPG