FGF1_CHICK
ID FGF1_CHICK Reviewed; 155 AA.
AC P19596;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Fibroblast growth factor 1;
DE Short=FGF-1;
DE AltName: Full=Acidic fibroblast growth factor;
DE Short=aFGF;
DE AltName: Full=Endothelial cell growth factor;
DE Short=ECGF;
DE AltName: Full=Heparin-binding growth factor 1;
DE Short=HBGF-1;
DE Contains:
DE RecName: Full=Endothelial cell growth factor alpha;
DE Flags: Precursor;
GN Name=FGF1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=1715259; DOI=10.1242/dev.111.4.1143;
RA Schnurch H., Risau W.;
RT "Differentiating and mature neurons express the acidic fibroblast growth
RT factor gene during chick neural development.";
RL Development 111:1143-1154(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Martin G.R., Han J.K.;
RL Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PROTEIN SEQUENCE OF 22-48.
RX PubMed=3402441; DOI=10.1002/j.1460-2075.1988.tb02901.x;
RA Risau W., Gautschi-Sova P., Boehlen P.;
RT "Endothelial cell growth factors in embryonic and adult chick brain are
RT related to human acidic fibroblast growth factor.";
RL EMBO J. 7:959-962(1988).
CC -!- FUNCTION: Plays an important role in the regulation of cell survival,
CC cell division, angiogenesis, cell differentiation and cell migration.
CC Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and
CC integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1
CC dimerization and activation via sequential autophosphorylation on
CC tyrosine residues which act as docking sites for interacting proteins,
CC leading to the activation of several signaling cascades. Binds to
CC integrins. Its binding to integrins and subsequent ternary complex
CC formation with integrins and FGFR1 are essential for FGF1 signaling.
CC {ECO:0000250|UniProtKB:P05230}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
CC Nucleus {ECO:0000250}. Note=Lacks a cleavable signal sequence. Within
CC the cytoplasm, it is transported to the cell membrane and then secreted
CC by a non-classical pathway that requires Cu(2+) ions and S100A13 (By
CC similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis
CC followed by translocation of FGF1 across endosomal membrane into the
CC cytosol. Nuclear import from the cytosol requires the classical nuclear
CC import machinery (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; S63263; AAB19629.1; -; mRNA.
DR EMBL; S63261; AAD13942.1; -; Genomic_DNA.
DR EMBL; U31863; AAA80310.1; -; mRNA.
DR PIR; A60130; A60130.
DR RefSeq; NP_990511.1; NM_205180.1.
DR RefSeq; XP_015149495.1; XM_015294009.1.
DR RefSeq; XP_015149496.1; XM_015294010.1.
DR AlphaFoldDB; P19596; -.
DR SMR; P19596; -.
DR STRING; 9031.ENSGALP00000011866; -.
DR PaxDb; P19596; -.
DR Ensembl; ENSGALT00000077414; ENSGALP00000044660; ENSGALG00000031255.
DR Ensembl; ENSGALT00000092341; ENSGALP00000066156; ENSGALG00000031255.
DR Ensembl; ENSGALT00000107416; ENSGALP00000070539; ENSGALG00000031255.
DR GeneID; 396094; -.
DR KEGG; gga:396094; -.
DR CTD; 2246; -.
DR VEuPathDB; HostDB:geneid_396094; -.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000160557; -.
DR HOGENOM; CLU_081609_5_1_1; -.
DR InParanoid; P19596; -.
DR OMA; MHADKNW; -.
DR OrthoDB; 1157770at2759; -.
DR PhylomeDB; P19596; -.
DR TreeFam; TF317805; -.
DR Reactome; R-GGA-109704; PI3K Cascade.
DR Reactome; R-GGA-1257604; PIP3 activates AKT signaling.
DR Reactome; R-GGA-190322; FGFR4 ligand binding and activation.
DR Reactome; R-GGA-5654228; Phospholipase C-mediated cascade, FGFR4.
DR Reactome; R-GGA-5654712; FRS-mediated FGFR4 signaling.
DR Reactome; R-GGA-5654719; SHC-mediated cascade:FGFR4.
DR Reactome; R-GGA-5654720; PI-3K cascade:FGFR4.
DR Reactome; R-GGA-5654733; Negative regulation of FGFR4 signaling.
DR Reactome; R-GGA-5673001; RAF/MAP kinase cascade.
DR Reactome; R-GGA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR PRO; PR:P19596; -.
DR Proteomes; UP000000539; Chromosome 13.
DR Bgee; ENSGALG00000031255; Expressed in heart and 8 other tissues.
DR ExpressionAtlas; P19596; baseline and differential.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; ISS:UniProtKB.
DR GO; GO:0008083; F:growth factor activity; ISS:UniProtKB.
DR GO; GO:0008201; F:heparin binding; ISS:UniProtKB.
DR GO; GO:0005178; F:integrin binding; ISS:UniProtKB.
DR GO; GO:0044548; F:S100 protein binding; ISS:UniProtKB.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0060681; P:branch elongation involved in ureteric bud branching; ISS:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0003347; P:epicardial cell to mesenchymal cell transition; TAS:DFLAT.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0030324; P:lung development; IBA:GO_Central.
DR GO; GO:0072163; P:mesonephric epithelium development; ISS:UniProtKB.
DR GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
DR GO; GO:0051781; P:positive regulation of cell division; ISS:UniProtKB.
DR GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0045542; P:positive regulation of cholesterol biosynthetic process; ISS:UniProtKB.
DR GO; GO:0010595; P:positive regulation of endothelial cell migration; IBA:GO_Central.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:1902533; P:positive regulation of intracellular signal transduction; ISS:UniProtKB.
DR GO; GO:0043406; P:positive regulation of MAP kinase activity; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR GO; GO:0042060; P:wound healing; IBA:GO_Central.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028210; FGF1.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF86; PTHR11486:SF86; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 1: Evidence at protein level;
KW Angiogenesis; Cytoplasm; Developmental protein; Differentiation;
KW Direct protein sequencing; Growth factor; Heparin-binding; Mitogen;
KW Nucleus; Reference proteome; Secreted.
FT PROPEP 1..15
FT /id="PRO_0000008920"
FT CHAIN 16..155
FT /note="Fibroblast growth factor 1"
FT /id="PRO_0000008921"
FT CHAIN 22..155
FT /note="Endothelial cell growth factor alpha"
FT /id="PRO_0000008922"
FT REGION 127..143
FT /note="Heparin-binding"
FT /evidence="ECO:0000250"
FT BINDING 33
FT /ligand="heparin"
FT /ligand_id="ChEBI:CHEBI:28304"
FT /evidence="ECO:0000250"
SQ SEQUENCE 155 AA; 17322 MW; 8EDB70545E2B4365 CRC64;
MAEGEITTFT ALTERFGLPL GNYKKPKLLY CSNGGHFLRI LPDGKVDGTR DRSDQHIQLQ
LSAEDVGEVY IKSTASGQYL AMDTNGLLYG SQLPGEECLF LERLEENHYN TYISKKHADK
NWFVGLKKNG NSKLGPRTHY GQKAILFLPL PVSAD
