FGF1_XENLA
ID FGF1_XENLA Reviewed; 155 AA.
AC Q6GLR6;
DT 09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Fibroblast growth factor 1;
DE Short=FGF-1;
DE AltName: Full=Acidic fibroblast growth factor;
DE Short=aFGF;
DE AltName: Full=Heparin-binding growth factor 1;
DE Short=HBGF-1;
DE Flags: Precursor;
GN Name=fgf1; Synonyms=fgf-1;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an important role in the regulation of cell survival,
CC cell division, angiogenesis, cell differentiation and cell migration.
CC Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and
CC integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1
CC dimerization and activation via sequential autophosphorylation on
CC tyrosine residues which act as docking sites for interacting proteins,
CC leading to the activation of several signaling cascades. Binds to
CC integrins. Its binding to integrins and subsequent ternary complex
CC formation with integrins and FGFR1 are essential for FGF1 signaling.
CC {ECO:0000250|UniProtKB:P05230}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
CC Nucleus {ECO:0000250}. Note=Lacks a cleavable signal sequence. Within
CC the cytoplasm, it is transported to the cell membrane and then secreted
CC by a non-classical pathway that requires Cu(2+) ions and S100A13 (By
CC similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis
CC followed by translocation of FGF1 across endosomal membrane into the
CC cytosol. Nuclear import from the cytosol requires the classical nuclear
CC import machinery (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC074391; AAH74391.1; -; mRNA.
DR RefSeq; NP_001086257.1; NM_001092788.1.
DR AlphaFoldDB; Q6GLR6; -.
DR SMR; Q6GLR6; -.
DR DNASU; 444686; -.
DR GeneID; 444686; -.
DR KEGG; xla:444686; -.
DR CTD; 444686; -.
DR Xenbase; XB-GENE-865566; fgf1.L.
DR OMA; HATHFLT; -.
DR OrthoDB; 1157770at2759; -.
DR Proteomes; UP000186698; Chromosome 3L.
DR Bgee; 444686; Expressed in muscle tissue and 18 other tissues.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; ISS:UniProtKB.
DR GO; GO:0008083; F:growth factor activity; ISS:UniProtKB.
DR GO; GO:0008201; F:heparin binding; ISS:UniProtKB.
DR GO; GO:0005178; F:integrin binding; ISS:UniProtKB.
DR GO; GO:0044548; F:S100 protein binding; ISS:UniProtKB.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0060681; P:branch elongation involved in ureteric bud branching; ISS:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0072163; P:mesonephric epithelium development; ISS:UniProtKB.
DR GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
DR GO; GO:0051781; P:positive regulation of cell division; ISS:UniProtKB.
DR GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0045542; P:positive regulation of cholesterol biosynthetic process; ISS:UniProtKB.
DR GO; GO:1902533; P:positive regulation of intracellular signal transduction; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028210; FGF1.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF86; PTHR11486:SF86; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Angiogenesis; Cytoplasm; Developmental protein; Differentiation;
KW Growth factor; Heparin-binding; Mitogen; Nucleus; Reference proteome;
KW Secreted.
FT PROPEP 1..15
FT /evidence="ECO:0000250"
FT /id="PRO_0000008925"
FT CHAIN 16..155
FT /note="Fibroblast growth factor 1"
FT /id="PRO_0000008926"
FT REGION 127..143
FT /note="Heparin-binding"
FT /evidence="ECO:0000250"
FT BINDING 33
FT /ligand="heparin"
FT /ligand_id="ChEBI:CHEBI:28304"
FT /evidence="ECO:0000250"
SQ SEQUENCE 155 AA; 17318 MW; 49F5F0E465BA6597 CRC64;
MAEGDITTFN AITESFSLPI GNYKKPKLLY CNNGGYFLRI LPEGVVDGTR DRNDLYITLK
LSALSQGEVH IKTTETGCYL AMDSSGQLYG TLTPNEECLF LETLEENHYN TYKSKKYADM
NWFVGIKKNG ASKKGSRTHY GQKAILFLPL PASPD
