FGF20_RAT
ID FGF20_RAT Reviewed; 212 AA.
AC Q9EST9;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Fibroblast growth factor 20;
DE Short=FGF-20;
GN Name=Fgf20;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=11032730; DOI=10.1006/bbrc.2000.3675;
RA Ohmachi S., Watanabe Y., Mikami T., Kusu N., Ibi T., Akaike A., Itoh N.;
RT "FGF-20, a novel neurotrophic factor, preferentially expressed in the
RT substantia nigra pars compacta of rat brain.";
RL Biochem. Biophys. Res. Commun. 277:355-360(2000).
CC -!- FUNCTION: Neurotrophic factor that regulates central nervous
CC development and function. May play an important role in dopaminergic
CC neurons in the substantia nigra.
CC -!- SUBUNIT: Homodimer. Interacts with FGFR2 and FGFR4. Affinity between
CC fibroblast growth factors (FGFs) and their receptors is increased by
CC heparan sulfate glycosaminoglycans that function as coreceptors (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Preferentially expressed in brain; substantia nigra
CC pars compacta. {ECO:0000269|PubMed:11032730}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; AB020021; BAB13763.1; -; mRNA.
DR PIR; JC7511; JC7511.
DR RefSeq; NP_076451.1; NM_023961.1.
DR AlphaFoldDB; Q9EST9; -.
DR SMR; Q9EST9; -.
DR STRING; 10116.ENSRNOP00000000121; -.
DR PhosphoSitePlus; Q9EST9; -.
DR PaxDb; Q9EST9; -.
DR PRIDE; Q9EST9; -.
DR Ensembl; ENSRNOT00000096927; ENSRNOP00000085396; ENSRNOG00000000109.
DR GeneID; 66017; -.
DR KEGG; rno:66017; -.
DR CTD; 26281; -.
DR RGD; 71068; Fgf20.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000158380; -.
DR HOGENOM; CLU_081609_0_0_1; -.
DR InParanoid; Q9EST9; -.
DR OMA; NIHKHGD; -.
DR OrthoDB; 1097566at2759; -.
DR PhylomeDB; Q9EST9; -.
DR TreeFam; TF317805; -.
DR Reactome; R-RNO-109704; PI3K Cascade.
DR Reactome; R-RNO-1257604; PIP3 activates AKT signaling.
DR Reactome; R-RNO-190322; FGFR4 ligand binding and activation.
DR Reactome; R-RNO-190371; FGFR3b ligand binding and activation.
DR Reactome; R-RNO-190372; FGFR3c ligand binding and activation.
DR Reactome; R-RNO-190373; FGFR1c ligand binding and activation.
DR Reactome; R-RNO-190375; FGFR2c ligand binding and activation.
DR Reactome; R-RNO-5654219; Phospholipase C-mediated cascade: FGFR1.
DR Reactome; R-RNO-5654221; Phospholipase C-mediated cascade, FGFR2.
DR Reactome; R-RNO-5654227; Phospholipase C-mediated cascade, FGFR3.
DR Reactome; R-RNO-5654228; Phospholipase C-mediated cascade, FGFR4.
DR Reactome; R-RNO-5654687; Downstream signaling of activated FGFR1.
DR Reactome; R-RNO-5654688; SHC-mediated cascade:FGFR1.
DR Reactome; R-RNO-5654689; PI-3K cascade:FGFR1.
DR Reactome; R-RNO-5654693; FRS-mediated FGFR1 signaling.
DR Reactome; R-RNO-5654695; PI-3K cascade:FGFR2.
DR Reactome; R-RNO-5654699; SHC-mediated cascade:FGFR2.
DR Reactome; R-RNO-5654700; FRS-mediated FGFR2 signaling.
DR Reactome; R-RNO-5654704; SHC-mediated cascade:FGFR3.
DR Reactome; R-RNO-5654706; FRS-mediated FGFR3 signaling.
DR Reactome; R-RNO-5654710; PI-3K cascade:FGFR3.
DR Reactome; R-RNO-5654712; FRS-mediated FGFR4 signaling.
DR Reactome; R-RNO-5654719; SHC-mediated cascade:FGFR4.
DR Reactome; R-RNO-5654720; PI-3K cascade:FGFR4.
DR Reactome; R-RNO-5654726; Negative regulation of FGFR1 signaling.
DR Reactome; R-RNO-5654727; Negative regulation of FGFR2 signaling.
DR Reactome; R-RNO-5654732; Negative regulation of FGFR3 signaling.
DR Reactome; R-RNO-5654733; Negative regulation of FGFR4 signaling.
DR Reactome; R-RNO-5673001; RAF/MAP kinase cascade.
DR Reactome; R-RNO-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR PRO; PR:Q9EST9; -.
DR Proteomes; UP000002494; Chromosome 16.
DR Bgee; ENSRNOG00000000109; Expressed in cerebellum.
DR Genevisible; Q9EST9; RN.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IGI:MGI.
DR GO; GO:0008083; F:growth factor activity; IDA:ParkinsonsUK-UCL.
DR GO; GO:0090722; F:receptor-receptor interaction; ISO:RGD.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; ISO:RGD.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IDA:MGI.
DR GO; GO:0042491; P:inner ear auditory receptor cell differentiation; IEA:Ensembl.
DR GO; GO:0060113; P:inner ear receptor cell differentiation; ISO:RGD.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISO:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:MGI.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0060043; P:regulation of cardiac muscle cell proliferation; ISO:RGD.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR GO; GO:0045664; P:regulation of neuron differentiation; ISO:RGD.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028291; FGF20.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF72; PTHR11486:SF72; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Growth factor; Reference proteome; Secreted.
FT CHAIN 1..212
FT /note="Fibroblast growth factor 20"
FT /id="PRO_0000147618"
SQ SEQUENCE 212 AA; 23537 MW; 4F858BEFE772B977 CRC64;
MAPLTEVGAF LGGLEGLGQQ VGSHFLLPPA GERPPLLGER RGALERGARG GPGSVELAHL
HGILRRRQLY CRTGFHLQIL PDGSVQGTRQ DHSLFGILEF ISVAVGLVSI RGVDSGLYLG
MNGKGELYGS EKLTSECIFR EQFEENWYNT YSSNIYKHGD TGRRYFVALN KDGTPRDGAR
SKRHQKFTHF LPRPVDPERV PELYKDLLVY TG
