FGF22_HUMAN
ID FGF22_HUMAN Reviewed; 170 AA.
AC Q9HCT0; B2RPH4;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Fibroblast growth factor 22;
DE Short=FGF-22;
DE Flags: Precursor;
GN Name=FGF22; ORFNames=UNQ2500/PRO5800;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Placenta;
RX PubMed=11342227; DOI=10.1016/s0167-4781(00)00302-x;
RA Nakatake Y., Hoshikawa M., Asaki T., Kassai Y., Itoh N.;
RT "Identification of a novel fibroblast growth factor, FGF-22, preferentially
RT expressed in the inner root sheath of the hair follicle.";
RL Biochim. Biophys. Acta 1517:460-463(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG NIEHS SNPs program;
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP INTERACTION WITH FGFBP1.
RX PubMed=15806171; DOI=10.1038/sj.onc.1208560;
RA Beer H.-D., Bittner M., Niklaus G., Munding C., Max N., Goppelt A.,
RA Werner S.;
RT "The fibroblast growth factor binding protein is a novel interaction
RT partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity:
RT implications for epithelial repair.";
RL Oncogene 24:5269-5277(2005).
RN [7]
RP INTERACTION WITH FGFR1 AND FGFR2, AND FUNCTION IN STIMULATION OF CELL
RP PROLIFERATION.
RX PubMed=16597617; DOI=10.1074/jbc.m601252200;
RA Zhang X., Ibrahimi O.A., Olsen S.K., Umemori H., Mohammadi M., Ornitz D.M.;
RT "Receptor specificity of the fibroblast growth factor family. The complete
RT mammalian FGF family.";
RL J. Biol. Chem. 281:15694-15700(2006).
RN [8]
RP REVIEW.
RX PubMed=20094046; DOI=10.1038/nrc2780;
RA Turner N., Grose R.;
RT "Fibroblast growth factor signalling: from development to cancer.";
RL Nat. Rev. Cancer 10:116-129(2010).
CC -!- FUNCTION: Plays a role in the fasting response, glucose homeostasis,
CC lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro).
CC May be involved in hair development. {ECO:0000269|PubMed:16597617}.
CC -!- SUBUNIT: Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.
CC {ECO:0000269|PubMed:15806171, ECO:0000269|PubMed:16597617}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC URL="http://egp.gs.washington.edu/data/fgf22/";
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DR EMBL; AB021925; BAB13479.1; -; mRNA.
DR EMBL; AY359084; AAQ89955.1; -; mRNA.
DR EMBL; AY426986; AAQ93357.1; -; Genomic_DNA.
DR EMBL; CH471242; EAW61175.1; -; Genomic_DNA.
DR EMBL; BC137444; AAI37445.1; -; mRNA.
DR EMBL; BC137445; AAI37446.1; -; mRNA.
DR CCDS; CCDS12037.1; -.
DR RefSeq; NP_065688.1; NM_020637.1.
DR AlphaFoldDB; Q9HCT0; -.
DR SMR; Q9HCT0; -.
DR BioGRID; 117951; 1.
DR STRING; 9606.ENSP00000215530; -.
DR ChEMBL; CHEMBL2362983; -.
DR iPTMnet; Q9HCT0; -.
DR PhosphoSitePlus; Q9HCT0; -.
DR BioMuta; FGF22; -.
DR DMDM; 13626689; -.
DR MassIVE; Q9HCT0; -.
DR PaxDb; Q9HCT0; -.
DR PeptideAtlas; Q9HCT0; -.
DR PRIDE; Q9HCT0; -.
DR ProteomicsDB; 81797; -.
DR Antibodypedia; 22338; 294 antibodies from 28 providers.
DR DNASU; 27006; -.
DR Ensembl; ENST00000215530.7; ENSP00000215530.4; ENSG00000070388.12.
DR GeneID; 27006; -.
DR KEGG; hsa:27006; -.
DR MANE-Select; ENST00000215530.7; ENSP00000215530.4; NM_020637.2; NP_065688.1.
DR UCSC; uc010xfq.3; human.
DR CTD; 27006; -.
DR DisGeNET; 27006; -.
DR GeneCards; FGF22; -.
DR HGNC; HGNC:3679; FGF22.
DR HPA; ENSG00000070388; Tissue enhanced (brain, skin).
DR MIM; 605831; gene.
DR neXtProt; NX_Q9HCT0; -.
DR OpenTargets; ENSG00000070388; -.
DR PharmGKB; PA28118; -.
DR VEuPathDB; HostDB:ENSG00000070388; -.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000161721; -.
DR HOGENOM; CLU_081609_3_0_1; -.
DR InParanoid; Q9HCT0; -.
DR OMA; NCKFMER; -.
DR OrthoDB; 1340221at2759; -.
DR PhylomeDB; Q9HCT0; -.
DR TreeFam; TF317805; -.
DR PathwayCommons; Q9HCT0; -.
DR Reactome; R-HSA-109704; PI3K Cascade.
DR Reactome; R-HSA-1257604; PIP3 activates AKT signaling.
DR Reactome; R-HSA-190370; FGFR1b ligand binding and activation.
DR Reactome; R-HSA-190377; FGFR2b ligand binding and activation.
DR Reactome; R-HSA-2033519; Activated point mutants of FGFR2.
DR Reactome; R-HSA-2219530; Constitutive Signaling by Aberrant PI3K in Cancer.
DR Reactome; R-HSA-5654219; Phospholipase C-mediated cascade: FGFR1.
DR Reactome; R-HSA-5654221; Phospholipase C-mediated cascade, FGFR2.
DR Reactome; R-HSA-5654687; Downstream signaling of activated FGFR1.
DR Reactome; R-HSA-5654688; SHC-mediated cascade:FGFR1.
DR Reactome; R-HSA-5654689; PI-3K cascade:FGFR1.
DR Reactome; R-HSA-5654693; FRS-mediated FGFR1 signaling.
DR Reactome; R-HSA-5654695; PI-3K cascade:FGFR2.
DR Reactome; R-HSA-5654699; SHC-mediated cascade:FGFR2.
DR Reactome; R-HSA-5654700; FRS-mediated FGFR2 signaling.
DR Reactome; R-HSA-5654726; Negative regulation of FGFR1 signaling.
DR Reactome; R-HSA-5654727; Negative regulation of FGFR2 signaling.
DR Reactome; R-HSA-5655253; Signaling by FGFR2 in disease.
DR Reactome; R-HSA-5658623; FGFRL1 modulation of FGFR1 signaling.
DR Reactome; R-HSA-5673001; RAF/MAP kinase cascade.
DR Reactome; R-HSA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR SignaLink; Q9HCT0; -.
DR BioGRID-ORCS; 27006; 10 hits in 1070 CRISPR screens.
DR GenomeRNAi; 27006; -.
DR Pharos; Q9HCT0; Tbio.
DR PRO; PR:Q9HCT0; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9HCT0; protein.
DR Bgee; ENSG00000070388; Expressed in skin of leg and 100 other tissues.
DR ExpressionAtlas; Q9HCT0; baseline and differential.
DR Genevisible; Q9HCT0; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005615; C:extracellular space; NAS:UniProtKB.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028296; FGF22.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF41; PTHR11486:SF41; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
PE 1: Evidence at protein level;
KW Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..170
FT /note="Fibroblast growth factor 22"
FT /id="PRO_0000008996"
SQ SEQUENCE 170 AA; 19663 MW; CB88918C2D5A4CE7 CRC64;
MRRRLWLGLA WLLLARAPDA AGTPSASRGP RSYPHLEGDV RWRRLFSSTH FFLRVDPGGR
VQGTRWRHGQ DSILEIRSVH VGVVVIKAVS SGFYVAMNRR GRLYGSRLYT VDCRFRERIE
ENGHNTYASQ RWRRRGQPMF LALDRRGGPR PGGRTRRYHL SAHFLPVLVS
