FGF22_MOUSE
ID FGF22_MOUSE Reviewed; 162 AA.
AC Q9ESS2;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Fibroblast growth factor 22;
DE Short=FGF-22;
DE Flags: Precursor;
GN Name=Fgf22;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11342227; DOI=10.1016/s0167-4781(00)00302-x;
RA Nakatake Y., Hoshikawa M., Asaki T., Kassai Y., Itoh N.;
RT "Identification of a novel fibroblast growth factor, FGF-22, preferentially
RT expressed in the inner root sheath of the hair follicle.";
RL Biochim. Biophys. Acta 1517:460-463(2001).
CC -!- FUNCTION: Plays a role in the fasting response, glucose homeostasis,
CC lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro).
CC May be involved in hair development.
CC -!- SUBUNIT: Interacts with FGFR1 and FGFR2. Interacts with FGFBP1 (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Preferentially expressed in skin; low expression in
CC brain. Expressed in the inner root sheath of the hair follicle.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB036765; BAB16407.1; -; mRNA.
DR CCDS; CCDS23988.1; -.
DR RefSeq; NP_075793.1; NM_023304.1.
DR AlphaFoldDB; Q9ESS2; -.
DR SMR; Q9ESS2; -.
DR BioGRID; 211948; 1.
DR STRING; 10090.ENSMUSP00000020577; -.
DR PhosphoSitePlus; Q9ESS2; -.
DR PaxDb; Q9ESS2; -.
DR PRIDE; Q9ESS2; -.
DR Antibodypedia; 22338; 294 antibodies from 28 providers.
DR DNASU; 67112; -.
DR Ensembl; ENSMUST00000219228; ENSMUSP00000151743; ENSMUSG00000020327.
DR GeneID; 67112; -.
DR KEGG; mmu:67112; -.
DR UCSC; uc007fzp.1; mouse.
DR CTD; 27006; -.
DR MGI; MGI:1914362; Fgf22.
DR VEuPathDB; HostDB:ENSMUSG00000020327; -.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000161721; -.
DR HOGENOM; CLU_081609_3_0_1; -.
DR InParanoid; Q9ESS2; -.
DR OMA; NCKFMER; -.
DR OrthoDB; 1340221at2759; -.
DR PhylomeDB; Q9ESS2; -.
DR TreeFam; TF317805; -.
DR Reactome; R-MMU-109704; PI3K Cascade.
DR Reactome; R-MMU-1257604; PIP3 activates AKT signaling.
DR Reactome; R-MMU-190370; FGFR1b ligand binding and activation.
DR Reactome; R-MMU-190377; FGFR2b ligand binding and activation.
DR Reactome; R-MMU-5654219; Phospholipase C-mediated cascade: FGFR1.
DR Reactome; R-MMU-5654221; Phospholipase C-mediated cascade, FGFR2.
DR Reactome; R-MMU-5654687; Downstream signaling of activated FGFR1.
DR Reactome; R-MMU-5654688; SHC-mediated cascade:FGFR1.
DR Reactome; R-MMU-5654689; PI-3K cascade:FGFR1.
DR Reactome; R-MMU-5654693; FRS-mediated FGFR1 signaling.
DR Reactome; R-MMU-5654695; PI-3K cascade:FGFR2.
DR Reactome; R-MMU-5654699; SHC-mediated cascade:FGFR2.
DR Reactome; R-MMU-5654700; FRS-mediated FGFR2 signaling.
DR Reactome; R-MMU-5654726; Negative regulation of FGFR1 signaling.
DR Reactome; R-MMU-5654727; Negative regulation of FGFR2 signaling.
DR Reactome; R-MMU-5658623; FGFRL1 modulation of FGFR1 signaling.
DR Reactome; R-MMU-5673001; RAF/MAP kinase cascade.
DR Reactome; R-MMU-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR BioGRID-ORCS; 67112; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q9ESS2; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9ESS2; protein.
DR Bgee; ENSMUSG00000020327; Expressed in lip and 36 other tissues.
DR ExpressionAtlas; Q9ESS2; baseline and differential.
DR Genevisible; Q9ESS2; MM.
DR GO; GO:0009986; C:cell surface; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IDA:MGI.
DR GO; GO:0005730; C:nucleolus; IDA:MGI.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028296; FGF22.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF41; PTHR11486:SF41; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..162
FT /note="Fibroblast growth factor 22"
FT /id="PRO_0000008997"
SQ SEQUENCE 162 AA; 18927 MW; 225EF512F4E1BE29 CRC64;
MRSRLWLGLA WLLLARAPGA PGGYPHLEGD VRWRRLFSST HFFLRVDLGG RVQGTRWRHG
QDSIVEIRSV RVGTVVIKAV YSGFYVAMNR RGRLYGSRVY SVDCRFRERI EENGYNTYAS
RRWRHRGRPM FLALDSQGIP RQGRRTRRHQ LSTHFLPVLV SS
