ID   FGF23_TETNG             Reviewed;         263 AA.
AC   Q5MK86;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Fibroblast growth factor 23;
DE            Short=FGF-23;
DE   Flags: Precursor;
GN   Name=fgf23; ORFNames=GSTENG00021542001;
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Head;
RX   PubMed=15590700; DOI=10.1093/hmg/ddi034;
RA   Benet-Pages A., Orlik P., Strom T.M., Lorenz-Depiereux B.;
RT   "An FGF23 missense mutation causes familial tumoral calcinosis with
RT   hyperphosphatemia.";
RL   Hum. Mol. Genet. 14:385-390(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC       {ECO:0000305}.
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DR   EMBL; AY753223; AAV97593.1; -; mRNA.
DR   EMBL; CAAE01014691; CAG02425.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5MK86; -.
DR   SMR; Q5MK86; -.
DR   STRING; 99883.ENSTNIP00000014355; -.
DR   Ensembl; ENSTNIT00000014553; ENSTNIP00000014355; ENSTNIG00000011410.
DR   KEGG; tng:GSTEN00021542G001; -.
DR   GeneTree; ENSGT00940000160821; -.
DR   HOGENOM; CLU_094251_3_0_1; -.
DR   InParanoid; Q5MK86; -.
DR   OMA; MHLYTDT; -.
DR   TreeFam; TF335872; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005104; F:fibroblast growth factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0055074; P:calcium ion homeostasis; IEA:Ensembl.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:InterPro.
DR   InterPro; IPR028304; FGF23.
DR   InterPro; IPR002209; Fibroblast_GF_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR11486; PTHR11486; 1.
DR   PANTHER; PTHR11486:SF69; PTHR11486:SF69; 1.
DR   Pfam; PF00167; FGF; 1.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Growth factor; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..263
FT                   /note="Fibroblast growth factor 23"
FT                   /id="PRO_0000042927"
FT   REGION          198..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        198..214
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        224..241
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        124
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        231
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        103..121
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   263 AA;  29109 MW;  EC8B60511D86B45F CRC64;
     MDVNRRIGVK DALLALLLAL LQGCPLGETA PNASPLVGSN WGNPRRYVHL QTSTDMSNFY
     LEIRLDGTVR KSTARTSYSV ILLKADTRER IAILGVKSNR YLCMDLEGSP FSSPTCIRDD
     CLFNHSLLEN NRDVYYSSRT GILFNLEGSR QVFVVGQNVP QTSLFLPRTN TVPLERLLLH
     RDKRNQVVDP SDPHRVAVGR AEEGSDSRAL QEDDADLEVE TEVEVGDDGR NASRERLQAP
     SDHDPWGVFS SNPGSPRSSG TVG