FGF2_CHICK
ID FGF2_CHICK Reviewed; 158 AA.
AC P48800;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Fibroblast growth factor 2;
DE Short=FGF-2;
DE AltName: Full=Basic fibroblast growth factor;
DE Short=bFGF;
DE AltName: Full=Heparin-binding growth factor 2;
DE Short=HBGF-2;
DE Flags: Precursor;
GN Name=FGF2;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7683281; DOI=10.1006/dbio.1993.1116;
RA Borja A.Z., Zeller R., Meijers C.;
RT "Expression of alternatively spliced bFGF first coding exons and antisense
RT mRNAs during chicken embryogenesis.";
RL Dev. Biol. 157:110-118(1993).
CC -!- FUNCTION: Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (By
CC similarity). Also acts as an integrin ligand which is required for FGF2
CC signaling (By similarity). Plays an important role in the regulation of
CC cell survival, cell division, cell differentiation and cell migration
CC (By similarity). Functions as a potent mitogen in vitro (By
CC similarity). Can induce angiogenesis (By similarity).
CC {ECO:0000250|UniProtKB:P09038}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P09038}. Nucleus
CC {ECO:0000250|UniProtKB:P09038}. Note=Exported from cells by an
CC endoplasmic reticulum (ER)/Golgi-independent mechanism (By similarity).
CC Unconventional secretion of FGF2 occurs by direct translocation across
CC the plasma membrane (By similarity). Binding of exogenous FGF2 to FGFR
CC facilitates endocytosis followed by translocation of FGF2 across
CC endosomal membrane into the cytosol (By similarity). Nuclear import
CC from the cytosol requires the classical nuclear import machinery (By
CC similarity). {ECO:0000250|UniProtKB:P09038}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; M95707; AAA48617.1; -; mRNA.
DR RefSeq; NP_990764.1; NM_205433.1.
DR AlphaFoldDB; P48800; -.
DR SMR; P48800; -.
DR STRING; 9031.ENSGALP00000031519; -.
DR Ensembl; ENSGALT00000032155; ENSGALP00000031519; ENSGALG00000011835.
DR GeneID; 396413; -.
DR KEGG; gga:396413; -.
DR CTD; 2247; -.
DR VEuPathDB; HostDB:geneid_396413; -.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000161583; -.
DR HOGENOM; CLU_081609_5_1_1; -.
DR InParanoid; P48800; -.
DR OMA; KGVCSNR; -.
DR OrthoDB; 1157770at2759; -.
DR PhylomeDB; P48800; -.
DR Reactome; R-GGA-109704; PI3K Cascade.
DR Reactome; R-GGA-1257604; PIP3 activates AKT signaling.
DR Reactome; R-GGA-190322; FGFR4 ligand binding and activation.
DR Reactome; R-GGA-3000170; Syndecan interactions.
DR Reactome; R-GGA-5654228; Phospholipase C-mediated cascade, FGFR4.
DR Reactome; R-GGA-5654712; FRS-mediated FGFR4 signaling.
DR Reactome; R-GGA-5654719; SHC-mediated cascade:FGFR4.
DR Reactome; R-GGA-5654720; PI-3K cascade:FGFR4.
DR Reactome; R-GGA-5654733; Negative regulation of FGFR4 signaling.
DR Reactome; R-GGA-5658623; FGFRL1 modulation of FGFR1 signaling.
DR Reactome; R-GGA-5673001; RAF/MAP kinase cascade.
DR Reactome; R-GGA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR PRO; PR:P48800; -.
DR Proteomes; UP000000539; Chromosome 4.
DR Bgee; ENSGALG00000011835; Expressed in testis and 12 other tissues.
DR ExpressionAtlas; P48800; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IDA:AgBase.
DR GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR GO; GO:0005730; C:nucleolus; IDA:AgBase.
DR GO; GO:0005634; C:nucleus; IDA:AgBase.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0008201; F:heparin binding; IPI:AgBase.
DR GO; GO:0005178; F:integrin binding; ISS:UniProtKB.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IMP:AgBase.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IMP:AgBase.
DR GO; GO:0008283; P:cell population proliferation; IMP:AgBase.
DR GO; GO:0003347; P:epicardial cell to mesenchymal cell transition; TAS:DFLAT.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0014843; P:growth factor dependent regulation of skeletal muscle satellite cell proliferation; ISS:AgBase.
DR GO; GO:0070660; P:inner ear receptor cell differentiation involved in inner ear sensory epithelium regeneration; NAS:AgBase.
DR GO; GO:0002089; P:lens morphogenesis in camera-type eye; NAS:AgBase.
DR GO; GO:0030324; P:lung development; IBA:GO_Central.
DR GO; GO:0001707; P:mesoderm formation; NAS:AgBase.
DR GO; GO:0072248; P:metanephric podocyte differentiation; NAS:AgBase.
DR GO; GO:0003407; P:neural retina development; TAS:AgBase.
DR GO; GO:0060563; P:neuroepithelial cell differentiation; IMP:AgBase.
DR GO; GO:0022008; P:neurogenesis; IMP:AgBase.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IMP:AgBase.
DR GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; ISS:UniProtKB.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0010595; P:positive regulation of endothelial cell migration; IBA:GO_Central.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0043406; P:positive regulation of MAP kinase activity; IBA:GO_Central.
DR GO; GO:0010756; P:positive regulation of plasminogen activation; IMP:AgBase.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR GO; GO:0072089; P:stem cell proliferation; IMP:AgBase.
DR GO; GO:0001894; P:tissue homeostasis; NAS:AgBase.
DR GO; GO:0042060; P:wound healing; IBA:GO_Central.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028223; FGF2.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF83; PTHR11486:SF83; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Angiogenesis; Developmental protein; Differentiation; Growth factor;
KW Heparin-binding; Mitogen; Nucleus; Reference proteome; Secreted.
FT PROPEP 1..12
FT /evidence="ECO:0000250"
FT /id="PRO_0000008942"
FT CHAIN 13..158
FT /note="Fibroblast growth factor 2"
FT /id="PRO_0000008943"
FT REGION 131..147
FT /note="Heparin-binding"
FT /evidence="ECO:0000250"
FT BINDING 39
FT /ligand="heparin"
FT /ligand_id="ChEBI:CHEBI:28304"
FT /evidence="ECO:0000250"
FT SITE 131
FT /note="Important for interaction with integrin"
FT /evidence="ECO:0000250|UniProtKB:P09038"
FT SITE 132
FT /note="Important for interaction with integrin"
FT /evidence="ECO:0000250|UniProtKB:P09038"
FT SITE 137
FT /note="Important for interaction with integrin"
FT /evidence="ECO:0000250|UniProtKB:P09038"
SQ SEQUENCE 158 AA; 17374 MW; 7B69B684C17F1816 CRC64;
MAAGAAGSIT TLPALPDDGG GGAFPPGHFK DPKRLYCKNG GFFLRINPDG RVDGVREKSD
PHIKLQLQAE ERGVVSIKGV SANRFLAMKE DGRLLALKCA TEECFFFERL ESNNYNTYRS
RKYSDWYVAL KRTGQYKPGP KTGPGQKAIL FLPMSAKS
