ID   AKAI1_MOUSE             Reviewed;          69 AA.
AC   G3UWD5;
DT   29-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=A-kinase anchor protein inhibitor 1;
GN   Name=Akain1 {ECO:0000312|MGI:MGI:2444600};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=25653177; DOI=10.1111/gtc.12217;
RA   Fukuda M., Aizawa Y.;
RT   "Hypothetical gene C18orf42 encodes a novel protein kinase A-binding
RT   protein.";
RL   Genes Cells 20:267-280(2015).
CC   -!- FUNCTION: Protein kinase A (PKA)-binding protein. Binds to type II
CC       regulatory subunits of protein kinase A (PKA) and may block the A-
CC       kinase anchoring protein (AKAP)-mediated subcellular localization of
CC       PKA. {ECO:0000250|UniProtKB:P0CW23}.
CC   -!- SUBUNIT: Binds cAMP-dependent protein kinase (PKA). Interacts
CC       specifically with RII-regulatory subunits of PKA (PRKAR2A and PRKAR2B).
CC       {ECO:0000250|UniProtKB:P0CW23}.
CC   -!- TISSUE SPECIFICITY: Preferentially expressed in the neural tissues.
CC       {ECO:0000269|PubMed:25653177}.
CC   -!- DOMAIN: The RII-alpha binding site, predicted to form an amphipathic
CC       helix, could participate in protein-protein interactions with a
CC       complementary surface on the R-subunit dimer.
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DR   EMBL; AC127693; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466537; EDL38356.1; -; Genomic_DNA.
DR   CCDS; CCDS50171.1; -.
DR   RefSeq; NP_001138664.1; NM_001145192.1.
DR   AlphaFoldDB; G3UWD5; -.
DR   SMR; G3UWD5; -.
DR   STRING; 10090.ENSMUSP00000131134; -.
DR   MaxQB; G3UWD5; -.
DR   PaxDb; G3UWD5; -.
DR   PRIDE; G3UWD5; -.
DR   ProteomicsDB; 285796; -.
DR   Antibodypedia; 62516; 10 antibodies from 8 providers.
DR   Ensembl; ENSMUST00000169935; ENSMUSP00000131134; ENSMUSG00000091636.
DR   GeneID; 320722; -.
DR   KEGG; mmu:320722; -.
DR   UCSC; uc008dkx.2; mouse.
DR   CTD; 642597; -.
DR   MGI; MGI:2444600; Akain1.
DR   VEuPathDB; HostDB:ENSMUSG00000091636; -.
DR   eggNOG; ENOG502SEI0; Eukaryota.
DR   GeneTree; ENSGT00560000078638; -.
DR   HOGENOM; CLU_2782380_0_0_1; -.
DR   InParanoid; G3UWD5; -.
DR   OMA; CELTKKH; -.
DR   OrthoDB; 1637092at2759; -.
DR   BioGRID-ORCS; 320722; 1 hit in 71 CRISPR screens.
DR   PRO; PR:G3UWD5; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   RNAct; G3UWD5; protein.
DR   Bgee; ENSMUSG00000091636; Expressed in facial nucleus and 33 other tissues.
DR   Genevisible; G3UWD5; MM.
DR   GO; GO:0005829; C:cytosol; IDA:MGI.
DR   GO; GO:0051018; F:protein kinase A binding; IDA:MGI.
DR   GO; GO:0031333; P:negative regulation of protein-containing complex assembly; IDA:MGI.
DR   GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR   GO; GO:0065003; P:protein-containing complex assembly; IDA:MGI.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..69
FT                   /note="A-kinase anchor protein inhibitor 1"
FT                   /id="PRO_0000432849"
FT   REGION          39..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   69 AA;  7751 MW;  A5737A685BF8F79B CRC64;
     MVFAPGEKSG KELEEVKLQN TSKQIVQNAI LQAMRQVSQE SLRREGRPGD SRAWGQLGGC
     ELTKKHEKK