FGF2_XENLA
ID FGF2_XENLA Reviewed; 155 AA.
AC P12226;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Fibroblast growth factor 2;
DE Short=FGF-2;
DE AltName: Full=Basic fibroblast growth factor;
DE Short=bFGF;
DE AltName: Full=Heparin-binding growth factor 2;
DE Short=HBGF-2;
DE Flags: Precursor;
GN Name=fgf2; Synonyms=fgf-2;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3194757; DOI=10.1126/science.3194757;
RA Kimelman D., Abraham J., Haaparanta T., Palisi T., Kirschner M.;
RT "The presence of fibroblast growth factor in the frog egg: its role as a
RT natural mesoderm inducer.";
RL Science 242:1053-1056(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 95-155.
RX PubMed=3479265; DOI=10.1016/0092-8674(87)90110-3;
RA Kimelman D., Kirschner M.;
RT "Synergistic induction of mesoderm by FGF and TGF-beta and the
RT identification of an mRNA coding for FGF in the early Xenopus embryo.";
RL Cell 51:869-877(1987).
CC -!- FUNCTION: Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (By
CC similarity). Also acts as an integrin ligand which is required for FGF2
CC signaling (By similarity). Plays an important role in the regulation of
CC cell survival, cell division, cell differentiation and cell migration
CC (By similarity). Functions as a potent mitogen in vitro. Can induce
CC angiogenesis (By similarity). {ECO:0000250|UniProtKB:P09038}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P09038}. Nucleus
CC {ECO:0000250|UniProtKB:P09038}. Note=Exported from cells by an
CC endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional
CC secretion of FGF2 occurs by direct translocation across the plasma
CC membrane (By similarity). Binding of exogenous FGF2 to FGFR facilitates
CC endocytosis followed by translocation of FGF2 across endosomal membrane
CC into the cytosol (By similarity). Nuclear import from the cytosol
CC requires the classical nuclear import machinery (By similarity).
CC {ECO:0000250|UniProtKB:P09038}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; M18067; AAA49726.1; -; mRNA.
DR PIR; A40117; A40117.
DR RefSeq; NP_001093341.1; NM_001099871.1.
DR AlphaFoldDB; P12226; -.
DR SMR; P12226; -.
DR GeneID; 100101279; -.
DR KEGG; xla:100101279; -.
DR CTD; 2247; -.
DR Xenbase; XB-GENE-487006; fgf2.L.
DR OMA; KGVCSNR; -.
DR OrthoDB; 1157770at2759; -.
DR Proteomes; UP000186698; Chromosome 1L.
DR Bgee; 100101279; Expressed in internal ear and 17 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0005178; F:integrin binding; ISS:UniProtKB.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0021533; P:cell differentiation in hindbrain; IDA:BHF-UCL.
DR GO; GO:0060825; P:fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; IDA:BHF-UCL.
DR GO; GO:0007498; P:mesoderm development; IDA:BHF-UCL.
DR GO; GO:0007399; P:nervous system development; IDA:BHF-UCL.
DR GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
DR GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; ISS:UniProtKB.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; ISS:UniProtKB.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028223; FGF2.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF83; PTHR11486:SF83; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Angiogenesis; Developmental protein; Differentiation; Growth factor;
KW Heparin-binding; Mitogen; Nucleus; Reference proteome; Secreted.
FT PROPEP 1..9
FT /id="PRO_0000008944"
FT CHAIN 10..155
FT /note="Fibroblast growth factor 2"
FT /id="PRO_0000008945"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 27..31
FT /ligand="heparin"
FT /ligand_id="ChEBI:CHEBI:28304"
FT /evidence="ECO:0000255"
FT BINDING 116..119
FT /ligand="heparin"
FT /ligand_id="ChEBI:CHEBI:28304"
FT /evidence="ECO:0000255"
FT SITE 128
FT /note="Important for interaction with integrin"
FT /evidence="ECO:0000250|UniProtKB:P09038"
FT SITE 129
FT /note="Important for interaction with integrin"
FT /evidence="ECO:0000250|UniProtKB:P09038"
FT SITE 134
FT /note="Important for interaction with integrin"
FT /evidence="ECO:0000250|UniProtKB:P09038"
FT CONFLICT 111
FT /note="Missing (in Ref. 2; no nucleotide entry)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 155 AA; 17241 MW; 036735C8063142FD CRC64;
MAAGSITTLP TESEDGGNTP FSPGSFKDPK RLYCKNGGFF LRINSDGRVD GSRDKSDSHI
KLQLQAVERG VVSIKGITAN RYLAMKEDGR LTSLRCITDE CFFFERLEAN NYNTYRSRKY
SSWYVALKRT GQYKNGSSTG PGQKAILFLP MSAKS
