ID   FGF3_CHICK              Reviewed;         220 AA.
AC   P48801;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Fibroblast growth factor 3;
DE            Short=FGF-3;
DE   AltName: Full=Heparin-binding growth factor 3;
DE            Short=HBGF-3;
DE   Flags: Precursor;
GN   Name=FGF3; Synonyms=FGF-3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Rhode Island red; TISSUE=Embryo;
RX   PubMed=7789270; DOI=10.1242/dev.121.5.1399;
RA   Mahmood R., Kiefer P., Guthrie S., Dickson C., Mason I.;
RT   "Multiple roles for FGF-3 during cranial neural development in the
RT   chicken.";
RL   Development 121:1399-1410(1995).
CC   -!- FUNCTION: Plays an important role in the regulation of embryonic
CC       development, cell proliferation, and cell differentiation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC       {ECO:0000305}.
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DR   EMBL; Z47555; CAA87635.1; -; mRNA.
DR   PIR; I50588; I50588.
DR   RefSeq; NP_990658.1; NM_205327.1.
DR   AlphaFoldDB; P48801; -.
DR   SMR; P48801; -.
DR   STRING; 9031.ENSGALP00000042296; -.
DR   PaxDb; P48801; -.
DR   Ensembl; ENSGALT00000046197; ENSGALP00000042296; ENSGALG00000026853.
DR   GeneID; 396267; -.
DR   KEGG; gga:396267; -.
DR   CTD; 2248; -.
DR   VEuPathDB; HostDB:geneid_396267; -.
DR   eggNOG; KOG3885; Eukaryota.
DR   GeneTree; ENSGT00940000161128; -.
DR   HOGENOM; CLU_081609_1_0_1; -.
DR   InParanoid; P48801; -.
DR   OMA; TLLQEPW; -.
DR   OrthoDB; 1157770at2759; -.
DR   PhylomeDB; P48801; -.
DR   Reactome; R-GGA-5658623; FGFRL1 modulation of FGFR1 signaling.
DR   PRO; PR:P48801; -.
DR   Proteomes; UP000000539; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0055026; P:negative regulation of cardiac muscle tissue development; IEA:Ensembl.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR   GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR   CDD; cd00058; FGF; 1.
DR   InterPro; IPR028232; FGF3.
DR   InterPro; IPR002209; Fibroblast_GF_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR11486; PTHR11486; 1.
DR   PANTHER; PTHR11486:SF26; PTHR11486:SF26; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00263; HBGFFGF.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Glycoprotein; Growth factor;
KW   Mitogen; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..220
FT                   /note="Fibroblast growth factor 3"
FT                   /id="PRO_0000008949"
FT   REGION          19..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        66
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   220 AA;  25050 MW;  B15D41D1E551C5D5 CRC64;
     MLVIWLLLLA LLPEPRVPAA TASPRAPRDA GGRGGVYEHL GGAPRRRKLY CATKYHLQIH
     PGGKINGTLE KNSVFSILEI TAVDVGIVAI KGLFSGRYLA MNKRGRLYAS ENYNTECEFV
     ERIHELGYNT YASRLYRTVP SGASTKRKAS AERLWYVSVN GKGRPRRGFK TRRTQKSSLF
     LPRVLDSKDH EMVRLFHTNV RYRESLLKPP SKNQRRRRGR