FGF3_DANRE
ID FGF3_DANRE Reviewed; 256 AA.
AC P48802;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Fibroblast growth factor 3;
DE Short=FGF-3;
DE AltName: Full=Heparin-binding growth factor 3;
DE Short=HBGF-3;
DE Flags: Precursor;
GN Name=fgf3; Synonyms=fgf-3;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8654946; DOI=10.1016/0378-1119(95)00736-9;
RA Kiefer P., Strahle U., Dickson C.;
RT "The zebrafish Fgf-3 gene: cDNA sequence, transcript structure and genomic
RT organization.";
RL Gene 168:211-215(1996).
RN [2]
RP CHARACTERIZATION, AND SUBCELLULAR LOCATION.
RX PubMed=8622866;
RA Kiefer P., Strahle U., Mason I., Dickson C.;
RT "Secretion and mitogenic activity of zebrafish FGF3 reveal intermediate
RT properties relative to mouse and Xenopus homologues.";
RL Oncogene 12:1503-1511(1996).
CC -!- FUNCTION: Plays an important role in the regulation of embryonic
CC development, cell proliferation, and cell differentiation.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:8622866}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; Z48714; CAA88596.1; -; Genomic_DNA.
DR PIR; JC4627; JC4627.
DR RefSeq; NP_571366.1; NM_131291.1.
DR AlphaFoldDB; P48802; -.
DR SMR; P48802; -.
DR BioGRID; 78723; 2.
DR STRING; 7955.ENSDARP00000099184; -.
DR PaxDb; P48802; -.
DR Ensembl; ENSDART00000168474; ENSDARP00000132485; ENSDARG00000101540.
DR GeneID; 30549; -.
DR KEGG; dre:30549; -.
DR CTD; 2248; -.
DR ZFIN; ZDB-GENE-980526-178; fgf3.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000161128; -.
DR HOGENOM; CLU_081609_1_0_1; -.
DR InParanoid; P48802; -.
DR OMA; TLLQEPW; -.
DR OrthoDB; 1157770at2759; -.
DR PhylomeDB; P48802; -.
DR TreeFam; TF317805; -.
DR Reactome; R-DRE-109704; PI3K Cascade.
DR Reactome; R-DRE-1257604; PIP3 activates AKT signaling.
DR Reactome; R-DRE-190370; FGFR1b ligand binding and activation.
DR Reactome; R-DRE-190377; FGFR2b ligand binding and activation.
DR Reactome; R-DRE-5654219; Phospholipase C-mediated cascade: FGFR1.
DR Reactome; R-DRE-5654221; Phospholipase C-mediated cascade, FGFR2.
DR Reactome; R-DRE-5654687; Downstream signaling of activated FGFR1.
DR Reactome; R-DRE-5654688; SHC-mediated cascade:FGFR1.
DR Reactome; R-DRE-5654689; PI-3K cascade:FGFR1.
DR Reactome; R-DRE-5654693; FRS-mediated FGFR1 signaling.
DR Reactome; R-DRE-5654695; PI-3K cascade:FGFR2.
DR Reactome; R-DRE-5654699; SHC-mediated cascade:FGFR2.
DR Reactome; R-DRE-5654700; FRS-mediated FGFR2 signaling.
DR Reactome; R-DRE-5654726; Negative regulation of FGFR1 signaling.
DR Reactome; R-DRE-5654727; Negative regulation of FGFR2 signaling.
DR Reactome; R-DRE-5658623; FGFRL1 modulation of FGFR1 signaling.
DR Reactome; R-DRE-5673001; RAF/MAP kinase cascade.
DR Reactome; R-DRE-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR PRO; PR:P48802; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 7.
DR Bgee; ENSDARG00000101540; Expressed in digestive tract epithelium and 68 other tissues.
DR ExpressionAtlas; P48802; baseline.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0031012; C:extracellular matrix; IDA:ZFIN.
DR GO; GO:0005615; C:extracellular space; IDA:ZFIN.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IDA:ZFIN.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0021984; P:adenohypophysis development; IMP:ZFIN.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IGI:ZFIN.
DR GO; GO:0051216; P:cartilage development; IMP:ZFIN.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0001708; P:cell fate specification; IMP:ZFIN.
DR GO; GO:0008283; P:cell population proliferation; IMP:ZFIN.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:ZFIN.
DR GO; GO:0071696; P:ectodermal placode development; IGI:ZFIN.
DR GO; GO:0048702; P:embryonic neurocranium morphogenesis; IGI:ZFIN.
DR GO; GO:0009880; P:embryonic pattern specification; IGI:ZFIN.
DR GO; GO:0060059; P:embryonic retina morphogenesis in camera-type eye; IGI:ZFIN.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0030902; P:hindbrain development; IMP:ZFIN.
DR GO; GO:0021854; P:hypothalamus development; IMP:ZFIN.
DR GO; GO:0042472; P:inner ear morphogenesis; IMP:ZFIN.
DR GO; GO:0021703; P:locus ceruleus development; IGI:ZFIN.
DR GO; GO:0030901; P:midbrain development; IGI:ZFIN.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IMP:ZFIN.
DR GO; GO:0014032; P:neural crest cell development; IMP:ZFIN.
DR GO; GO:0021985; P:neurohypophysis development; IMP:ZFIN.
DR GO; GO:0048666; P:neuron development; IGI:ZFIN.
DR GO; GO:0048665; P:neuron fate specification; IGI:ZFIN.
DR GO; GO:0048709; P:oligodendrocyte differentiation; IGI:ZFIN.
DR GO; GO:0043049; P:otic placode formation; IMP:ZFIN.
DR GO; GO:0071599; P:otic vesicle development; IGI:ZFIN.
DR GO; GO:0030916; P:otic vesicle formation; IMP:ZFIN.
DR GO; GO:0048840; P:otolith development; IGI:ZFIN.
DR GO; GO:0007422; P:peripheral nervous system development; IGI:ZFIN.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0030335; P:positive regulation of cell migration; IGI:ZFIN.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0050769; P:positive regulation of neurogenesis; IMP:ZFIN.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IMP:ZFIN.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0030177; P:positive regulation of Wnt signaling pathway; IGI:ZFIN.
DR GO; GO:0048920; P:posterior lateral line neuromast primordium migration; IGI:ZFIN.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR GO; GO:0060041; P:retina development in camera-type eye; IGI:ZFIN.
DR GO; GO:0021571; P:rhombomere 5 development; IGI:ZFIN.
DR GO; GO:0021572; P:rhombomere 6 development; IGI:ZFIN.
DR GO; GO:0001501; P:skeletal system development; IMP:ZFIN.
DR GO; GO:0060118; P:vestibular receptor cell development; IMP:ZFIN.
DR GO; GO:0016055; P:Wnt signaling pathway; IMP:ZFIN.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028232; FGF3.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF26; PTHR11486:SF26; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; Growth factor; Mitogen;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..256
FT /note="Fibroblast growth factor 3"
FT /id="PRO_0000008950"
FT REGION 31..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 151..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..54
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..234
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..249
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 256 AA; 28923 MW; CEBA1C72A170BBDC CRC64;
MVIILLLLLL SFLDPSLEES LAPRLTRTPR APCARGQACD PRQRRDAGGR GGVYEHLGGA
PRRRKLYCAT KYHLQIHPNG KIDGSLEENN PLSILEITAV DVGVVAIKGL FSGRYLAMNE
KGRLYASEVF NRECEFLERI HELGYNTYAS RHHATTQPPP TGSGIGGSKR RASSKRQWYV
SINGKGRPRR GFKTRSTDKA SLFLPRVLAN KDHEMVRKLR ESQRHHTGSH RAPVGRAERR
RRRHRGSKGH NRRADI
