FGF3_MOUSE
ID FGF3_MOUSE Reviewed; 245 AA.
AC P05524; Q61736;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 3.
DT 25-MAY-2022, entry version 140.
DE RecName: Full=Fibroblast growth factor 3;
DE Short=FGF-3;
DE AltName: Full=Heparin-binding growth factor 3;
DE Short=HBGF-3;
DE AltName: Full=Proto-oncogene Int-2;
DE Flags: Precursor;
GN Name=Fgf3; Synonyms=Fgf-3, Int-2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 2), ALTERNATIVE INITIATION, SUBCELLULAR
RP LOCATION, AND MUTAGENESIS OF ASN-65.
RX PubMed=2406607; DOI=10.1038/343662a0;
RA Acland P., Dixon M., Peters G., Dickson C.;
RT "Subcellular fate of the int-2 oncoprotein is determined by choice of
RT initiation codon.";
RL Nature 343:662-665(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3013624; DOI=10.1002/j.1460-2075.1986.tb04304.x;
RA Moore R., Casey G., Brookes S., Dixon M., Peters G., Dickson C.;
RT "Sequence, topography and protein coding potential of mouse int-2: a
RT putative oncogene activated by mouse mammary tumour virus.";
RL EMBO J. 5:919-924(1986).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-73 (ISOFORM 1).
RX PubMed=2841106; DOI=10.1002/j.1460-2075.1988.tb02908.x;
RA Smith R., Peters G., Dickson C.;
RT "Multiple RNAs expressed from the int-2 gene in mouse embryonal carcinoma
RT cell lines encode a protein with homology to fibroblast growth factors.";
RL EMBO J. 7:1013-1022(1988).
RN [4]
RP CHARACTERIZATION.
RX PubMed=1964688; DOI=10.1242/jcs.1990.supplement_13.9;
RA Dickson C., Acland P., Smith R., Dixon M., Deed R., McAllan D., Walther W.,
RA Fuller-Pace F., Kiefer P., Peters G.;
RT "Characterization of int-2: a member of the fibroblast growth factor
RT family.";
RL J. Cell Sci. Suppl. 13:87-96(1990).
CC -!- FUNCTION: Plays an important role in the regulation of embryonic
CC development, cell proliferation, and cell differentiation. Required for
CC normal ear development (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with FGFR1 and FGFR2. Affinity between fibroblast
CC growth factors (FGFs) and their receptors is increased by heparan
CC sulfate glycosaminoglycans that function as coreceptors (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Nucleus.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum. Golgi
CC apparatus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative initiation; Named isoforms=2;
CC Name=2;
CC IsoId=P05524-1; Sequence=Displayed;
CC Name=1;
CC IsoId=P05524-2; Sequence=VSP_018727;
CC -!- INDUCTION: By integration of mouse mammary tumor virus.
CC -!- PTM: Glycosylated.
CC -!- MISCELLANEOUS: [Isoform 1]: Starts at an alternative CUG codon.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA68767.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X52014; CAA36261.1; -; mRNA.
DR EMBL; Y00848; CAA68767.1; ALT_INIT; Genomic_DNA.
DR CCDS; CCDS22051.1; -. [P05524-1]
DR PIR; A23930; TVMST2.
DR AlphaFoldDB; P05524; -.
DR SMR; P05524; -.
DR STRING; 10090.ENSMUSP00000101518; -.
DR GlyGen; P05524; 1 site.
DR iPTMnet; P05524; -.
DR PhosphoSitePlus; P05524; -.
DR PaxDb; P05524; -.
DR PRIDE; P05524; -.
DR MGI; MGI:95517; Fgf3.
DR eggNOG; KOG3885; Eukaryota.
DR InParanoid; P05524; -.
DR PhylomeDB; P05524; -.
DR Reactome; R-MMU-109704; PI3K Cascade.
DR Reactome; R-MMU-1257604; PIP3 activates AKT signaling.
DR Reactome; R-MMU-190370; FGFR1b ligand binding and activation.
DR Reactome; R-MMU-190377; FGFR2b ligand binding and activation.
DR Reactome; R-MMU-5654219; Phospholipase C-mediated cascade: FGFR1.
DR Reactome; R-MMU-5654221; Phospholipase C-mediated cascade, FGFR2.
DR Reactome; R-MMU-5654687; Downstream signaling of activated FGFR1.
DR Reactome; R-MMU-5654688; SHC-mediated cascade:FGFR1.
DR Reactome; R-MMU-5654689; PI-3K cascade:FGFR1.
DR Reactome; R-MMU-5654693; FRS-mediated FGFR1 signaling.
DR Reactome; R-MMU-5654695; PI-3K cascade:FGFR2.
DR Reactome; R-MMU-5654699; SHC-mediated cascade:FGFR2.
DR Reactome; R-MMU-5654700; FRS-mediated FGFR2 signaling.
DR Reactome; R-MMU-5654726; Negative regulation of FGFR1 signaling.
DR Reactome; R-MMU-5654727; Negative regulation of FGFR2 signaling.
DR Reactome; R-MMU-5658623; FGFRL1 modulation of FGFR1 signaling.
DR Reactome; R-MMU-5673001; RAF/MAP kinase cascade.
DR Reactome; R-MMU-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR PRO; PR:P05524; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P05524; protein.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IDA:MGI.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IDA:MGI.
DR GO; GO:0055026; P:negative regulation of cardiac muscle tissue development; ISO:MGI.
DR GO; GO:0001759; P:organ induction; IGI:MGI.
DR GO; GO:0030916; P:otic vesicle formation; IGI:MGI.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0036342; P:post-anal tail morphogenesis; IMP:MGI.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR GO; GO:0048752; P:semicircular canal morphogenesis; IGI:MGI.
DR GO; GO:0048538; P:thymus development; IMP:MGI.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028232; FGF3.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF26; PTHR11486:SF26; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 1: Evidence at protein level;
KW Alternative initiation; Developmental protein; Differentiation;
KW Endoplasmic reticulum; Glycoprotein; Golgi apparatus; Growth factor;
KW Mitogen; Nucleus; Proto-oncogene; Reference proteome; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..245
FT /note="Fibroblast growth factor 3"
FT /id="PRO_0000238784"
FT REGION 137..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 65
FT /note="N-linked (GlcNAc...) asparagine"
FT VAR_SEQ 1
FT /note="M -> MARGRVLPAPRLRETRAGAAAAAGGRDAG (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:2841106"
FT /id="VSP_018727"
FT MUTAGEN 65
FT /note="N->Q: Not glycosylated."
FT /evidence="ECO:0000269|PubMed:2406607"
SQ SEQUENCE 245 AA; 27214 MW; 70D94FD6A7837C79 CRC64;
MGLIWLLLLS LLEPSWPTTG PGTRLRRDAG GRGGVYEHLG GAPRRRKLYC ATKYHLQLHP
SGRVNGSLEN SAYSILEITA VEVGVVAIKG LFSGRYLAMN KRGRLYASDH YNAECEFVER
IHELGYNTYA SRLYRTGSSG PGAQRQPGAQ RPWYVSVNGK GRPRRGFKTR RTQKSSLFLP
RVLGHKDHEM VRLLQSSQPR APGEGSQPRQ RRQKKQSPGD HGKMETLSTR ATPSTQLHTG
GLAVA
