ID   FGF3_XENLA              Reviewed;         237 AA.
AC   P36386;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Fibroblast growth factor 3;
DE            Short=FGF-3;
DE   AltName: Full=Heparin-binding growth factor 3;
DE            Short=HBGF-3;
DE   AltName: Full=INT-2;
DE   Flags: Precursor;
GN   Name=fgf3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RX   PubMed=8223431; DOI=10.1002/j.1460-2075.1993.tb06100.x;
RA   Kiefer P., Mathieu M., Close J.M., Peters G., Dickson C.;
RT   "FGF3 from Xenopus laevis.";
RL   EMBO J. 12:4159-4168(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 39-137.
RC   TISSUE=Neurula;
RX   PubMed=1425349; DOI=10.1242/dev.115.3.695;
RA   Tannahill D., Isaacs H.V., Close M.J., Peters G., Slack J.M.W.;
RT   "Developmental expression of the Xenopus int-2 (FGF-3) gene: activation by
RT   mesodermal and neural induction.";
RL   Development 115:695-702(1992).
CC   -!- FUNCTION: Plays an important role in the regulation of embryonic
CC       development, cell proliferation, and cell differentiation.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC       {ECO:0000305}.
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DR   EMBL; Z25539; CAA80987.1; -; mRNA.
DR   EMBL; X65237; CAA46341.1; -; mRNA.
DR   PIR; S39582; S39582.
DR   RefSeq; NP_001079132.1; NM_001085663.1.
DR   AlphaFoldDB; P36386; -.
DR   SMR; P36386; -.
DR   BioGRID; 96890; 4.
DR   GeneID; 373669; -.
DR   KEGG; xla:373669; -.
DR   CTD; 373669; -.
DR   Xenbase; XB-GENE-17332732; fgf3.L.
DR   OrthoDB; 1157770at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 373669; Expressed in internal ear and 4 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005104; F:fibroblast growth factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   CDD; cd00058; FGF; 1.
DR   InterPro; IPR028232; FGF3.
DR   InterPro; IPR002209; Fibroblast_GF_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR11486; PTHR11486; 1.
DR   PANTHER; PTHR11486:SF26; PTHR11486:SF26; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00263; HBGFFGF.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; Differentiation; Direct protein sequencing;
KW   Glycoprotein; Growth factor; Mitogen; Reference proteome; Signal.
FT   SIGNAL          1..21
FT   CHAIN           22..237
FT                   /note="Fibroblast growth factor 3"
FT                   /id="PRO_0000008951"
FT   CARBOHYD        83
FT                   /note="N-linked (GlcNAc...) asparagine"
SQ   SEQUENCE   237 AA;  26984 MW;  EDD31B0893567A2D CRC64;
     MVIIWILLLS FISCGPQVSW AKRLEREPKY PCSRGGKLCD PRQRRDAGGR GGVYEHLGGA
     PRNRKLYCAT KYHLQIHLNG KINGTLEKNS VFSILEITAV DVGIVAIKGL FSGRYLAMNQ
     RGRLYASETY NPECEFVERI HELGYNTYAS RLYRTVPSGA GTKRKASAER LWYVSINGKG
     RPRRGFKTRR TQKSSLFLPR VLDNKDHDAV RLFHTNAVYR ESILKPSKPS GRQRRGQ