ID   FGF4A_XENLA             Reviewed;         187 AA.
AC   P48805;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Fibroblast growth factor 4A;
DE            Short=FGF-4A;
DE   AltName: Full=Embryonic fibroblast growth factor I;
DE            Short=xEFGF-I;
DE   AltName: Full=Heparin-binding growth factor 4-I;
DE            Short=HBGF-4-I;
DE   Flags: Precursor;
GN   Name=fgf4-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX   PubMed=1618138; DOI=10.1242/dev.114.3.711;
RA   Isaacs H.V., Tannahill D., Slack J.M.W.;
RT   "Expression of a novel FGF in the Xenopus embryo. A new candidate inducing
RT   factor for mesoderm formation and anteroposterior specification.";
RL   Development 114:711-720(1992).
RN   [2]
RP   INDUCTION.
RX   PubMed=10068640; DOI=10.1242/dev.126.7.1467;
RA   Sun B.I., Bush S.M., Collins-Racie L.A., LaVallie E.R.,
RA   DiBlasio-Smith E.A., Wolfman N.M., McCoy J.M., Sive H.L.;
RT   "derriere: a TGF-beta family member required for posterior development in
RT   Xenopus.";
RL   Development 126:1467-1482(1999).
CC   -!- FUNCTION: Plays an important role in the regulation of embryonic
CC       development, cell proliferation, and cell differentiation. Good
CC       candidate for an inducing factor with possible roles both in mesoderm
CC       induction at the blastula stage and in the formation of the
CC       anteroposterior axis at the gastrula stage.
CC       {ECO:0000269|PubMed:1618138}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- INDUCTION: By derriere. {ECO:0000269|PubMed:10068640}.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC       {ECO:0000305}.
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DR   EMBL; X62593; CAA44479.1; -; mRNA.
DR   PIR; S23595; S23595.
DR   RefSeq; NP_001079292.1; NM_001085823.1.
DR   AlphaFoldDB; P48805; -.
DR   SMR; P48805; -.
DR   GeneID; 378586; -.
DR   KEGG; xla:378586; -.
DR   CTD; 378586; -.
DR   Xenbase; XB-GENE-6252641; fgf4.L.
DR   OrthoDB; 786008at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 378586; Expressed in muscle tissue and 2 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005104; F:fibroblast growth factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0080159; P:zygote elongation; IMP:BHF-UCL.
DR   CDD; cd00058; FGF; 1.
DR   InterPro; IPR028239; FGF4.
DR   InterPro; IPR002209; Fibroblast_GF_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR11486; PTHR11486; 1.
DR   PANTHER; PTHR11486:SF31; PTHR11486:SF31; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00263; HBGFFGF.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Growth factor; Mitogen;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..187
FT                   /note="Fibroblast growth factor 4A"
FT                   /id="PRO_0000008956"
SQ   SEQUENCE   187 AA;  21223 MW;  AAE63D65E82AD1BD CRC64;
     MTVPSALVPI LLLGTAAVMV QCLPLSFQRN DTVERRWETL FSRSMGEKKD TSRDSDYLLG
     IKRQRRLYCN VGIGFHIQVL PDGRINGMHS ENRYSLLELS PVEVGVVSLY GVKSGMFVAM
     NAKGKLYGSR YFNEECKFKE TLLPNNYNAY ESRKYPGMYI ALGKNGRTKK GNRVSPTMTL
     THFLPRI