FGF4B_XENLA
ID FGF4B_XENLA Reviewed; 192 AA.
AC P48806;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Fibroblast growth factor 4B;
DE Short=FGF-4B;
DE AltName: Full=Embryonic fibroblast growth factor II;
DE Short=xEFGF-II;
DE AltName: Full=Fibroblast growth factor 4-II;
DE Short=FGF-4-II;
DE AltName: Full=Heparin-binding growth factor 4-II;
DE Short=HBGF-4-II;
DE Flags: Precursor;
GN Name=fgf4-b;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=1618138; DOI=10.1242/dev.114.3.711;
RA Isaacs H.V., Tannahill D., Slack J.M.W.;
RT "Expression of a novel FGF in the Xenopus embryo. A new candidate inducing
RT factor for mesoderm formation and anteroposterior specification.";
RL Development 114:711-720(1992).
RN [2]
RP INDUCTION.
RX PubMed=10068640; DOI=10.1242/dev.126.7.1467;
RA Sun B.I., Bush S.M., Collins-Racie L.A., LaVallie E.R.,
RA DiBlasio-Smith E.A., Wolfman N.M., McCoy J.M., Sive H.L.;
RT "derriere: a TGF-beta family member required for posterior development in
RT Xenopus.";
RL Development 126:1467-1482(1999).
CC -!- FUNCTION: Plays an important role in the regulation of embryonic
CC development, cell proliferation, and cell differentiation. Good
CC candidate for an inducing factor with possible roles both in mesoderm
CC induction at the blastula stage and in the formation of the
CC anteroposterior axis at the gastrula stage.
CC {ECO:0000269|PubMed:1618138}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- INDUCTION: By derriere. {ECO:0000269|PubMed:10068640}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; X62594; CAA44480.1; -; mRNA.
DR PIR; S54407; S54407.
DR RefSeq; NP_001079293.1; NM_001085824.1.
DR AlphaFoldDB; P48806; -.
DR SMR; P48806; -.
DR GeneID; 378587; -.
DR KEGG; xla:378587; -.
DR CTD; 378587; -.
DR Xenbase; XB-GENE-865382; fgf4.S.
DR OMA; YESHTYP; -.
DR OrthoDB; 1183051at2759; -.
DR Proteomes; UP000186698; Chromosome 4S.
DR Bgee; 378587; Expressed in neurula embryo.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:InterPro.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028239; FGF4.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF31; PTHR11486:SF31; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Growth factor; Mitogen;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..192
FT /note="Fibroblast growth factor 4B"
FT /id="PRO_0000008957"
SQ SEQUENCE 192 AA; 21904 MW; 2B01B0BB8824E3B3 CRC64;
MTVQLALVPI LLLGTAAVMV HCMPFSSSQR NDTLERRWET LFSRSMARIP GEKKDMSRES
DYLLGIKRLR RLYCNVGIGF HIQVLPDGRI NGMHNENRYS LLEISPVEVG VVSLYGIKSA
MFVAMNAKGK LYGSRYFNEE CKFKETLLPN NYNAYESRKY PGMYIALGKN GRTKKGNRVS
PTMTLTHFLP RI
