FGF4_BOVIN
ID FGF4_BOVIN Reviewed; 206 AA.
AC P48803;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Fibroblast growth factor 4;
DE Short=FGF-4;
DE AltName: Full=Heparin secretory-transforming protein;
DE Short=HST;
DE AltName: Full=Heparin-binding growth factor 4;
DE Short=HBGF-4;
DE Flags: Precursor;
GN Name=FGF4; Synonyms=HST;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Thymus;
RX PubMed=7557455; DOI=10.1016/0378-1119(95)00330-9;
RA Yu J.C., Deseabra A.J., Wang L.M., Fleming T.P., Chedid M., Miki T.,
RA Heidaran M.A.;
RT "An unexpected transforming gene in calf-thymus carrier DNA: bovine hst.";
RL Gene 162:333-334(1995).
CC -!- FUNCTION: Plays an important role in the regulation of embryonic
CC development, cell proliferation, and cell differentiation. Required for
CC normal limb and cardiac valve development during embryogenesis (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between
CC fibroblast growth factors (FGFs) and their receptors is increased by
CC heparan sulfate glycosaminoglycans that function as coreceptors (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; U15969; AAA91622.1; -; Genomic_DNA.
DR PIR; JC4268; JC4268.
DR AlphaFoldDB; P48803; -.
DR SMR; P48803; -.
DR STRING; 9913.ENSBTAP00000029936; -.
DR PaxDb; P48803; -.
DR eggNOG; KOG3885; Eukaryota.
DR InParanoid; P48803; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028239; FGF4.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF31; PTHR11486:SF31; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 3: Inferred from homology;
KW Developmental protein; Differentiation; Growth factor; Mitogen;
KW Proto-oncogene; Reference proteome; Secreted; Signal.
FT SIGNAL 1..29
FT /evidence="ECO:0000255"
FT CHAIN 30..206
FT /note="Fibroblast growth factor 4"
FT /id="PRO_0000008952"
SQ SEQUENCE 206 AA; 22042 MW; F9B7A86066E56613 CRC64;
MAGPGTAAAA LLPAVLLAVL APWAGRGGAA PTAPNGTLEA ELERRWESLV ARSLLAGLPV
AAQPKEAAVQ SGAGDYLLGI KRLRRLYCNV GIGFHLQVLP DGRIGGVHAD TSDSLLELSP
VERGVVSIFG VASRFFVAMS SRGRLYGSPF FTDECRFREI LLPNNYNAYE CDRHPGMFIA
LSKNGKAKKG NRVSPTMKVT HFLPRL
