ID   FGF4_CHICK              Reviewed;         194 AA.
AC   P48804;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Fibroblast growth factor 4;
DE            Short=FGF-4;
DE   AltName: Full=Heparin-binding growth factor 4;
DE            Short=HBGF-4;
DE   Flags: Precursor;
GN   Name=FGF4; Synonyms=FGF-4;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7935794; DOI=10.1038/371609a0;
RA   Niswander L., Jeffrey S., Martin G.R., Tickle C.;
RT   "A positive feedback loop coordinates growth and patterning in the
RT   vertebrate limb.";
RL   Nature 371:609-612(1994).
CC   -!- FUNCTION: Plays an important role in the regulation of embryonic
CC       development, cell proliferation, and cell differentiation. Required for
CC       normal limb development during embryogenesis (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Reciprocal interactions may create a positive feedback loop
CC       between sonic hedgehog (SHH) and FGF4.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Posterior ridge.
CC   -!- INDUCTION: By retinoic acid.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC       {ECO:0000305}.
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DR   EMBL; U14654; AAA58706.1; -; Genomic_DNA.
DR   PIR; S78506; I50710.
DR   AlphaFoldDB; P48804; -.
DR   SMR; P48804; -.
DR   STRING; 9031.ENSGALP00000012214; -.
DR   VEuPathDB; HostDB:geneid_428857; -.
DR   InParanoid; P48804; -.
DR   OrthoDB; 1183051at2759; -.
DR   PhylomeDB; P48804; -.
DR   PRO; PR:P48804; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005104; F:fibroblast growth factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   CDD; cd00058; FGF; 1.
DR   InterPro; IPR028239; FGF4.
DR   InterPro; IPR002209; Fibroblast_GF_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR11486; PTHR11486; 1.
DR   PANTHER; PTHR11486:SF31; PTHR11486:SF31; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00263; HBGFFGF.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Growth factor; Mitogen;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..194
FT                   /note="Fibroblast growth factor 4"
FT                   /id="PRO_0000008955"
SQ   SEQUENCE   194 AA;  21642 MW;  5D44245BE97E664A CRC64;
     MLSAAALLPA LLLGLLWPGA VRGRPPPGRL PPGPRQRRWD AALFARSVAR LPAERRDAAR
     DGDYLLGYKR LRRLYCNVGI GFHIQVLPDG RIDGIHSENR YSLLEISPVE RGVVSIFGVR
     SGLFVAMNSK GKLYGSTHVN DECKFKEILL PNNYNAYESR IYPGMYIALS KNGRTKKGNK
     VSPTMTVTHF LPRI