ID   FGF5_BOVIN              Reviewed;         270 AA.
AC   A0MTF4;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Fibroblast growth factor 5;
DE            Short=FGF-5;
DE   Flags: Precursor;
GN   Name=FGF5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Skin;
RA   Schmutz S.M., Berryere T.G., Oulmouden A.;
RT   "Genetic studies of coat colors and length in Highland cattle.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the regulation of cell
CC       proliferation and cell differentiation. Required for normal regulation
CC       of the hair growth cycle. Functions as an inhibitor of hair elongation
CC       by promoting progression from anagen, the growth phase of the hair
CC       follicle, into catagen the apoptosis-induced regression phase (By
CC       similarity). {ECO:0000250|UniProtKB:Q20FD0}.
CC   -!- SUBUNIT: Interacts with FGFR1 and FGFR2. Affinity between fibroblast
CC       growth factors (FGFs) and their receptors is increased by heparan
CC       sulfate glycosaminoglycans that function as coreceptors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC       {ECO:0000305}.
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DR   EMBL; EF042192; ABK34274.1; -; mRNA.
DR   RefSeq; NP_001071479.2; NM_001078011.2.
DR   AlphaFoldDB; A0MTF4; -.
DR   SMR; A0MTF4; -.
DR   STRING; 9913.ENSBTAP00000023064; -.
DR   PaxDb; A0MTF4; -.
DR   Ensembl; ENSBTAT00000023064; ENSBTAP00000023064; ENSBTAG00000017348.
DR   GeneID; 536771; -.
DR   KEGG; bta:536771; -.
DR   CTD; 2250; -.
DR   VEuPathDB; HostDB:ENSBTAG00000017348; -.
DR   VGNC; VGNC:28980; FGF5.
DR   eggNOG; KOG3885; Eukaryota.
DR   GeneTree; ENSGT00940000158449; -.
DR   HOGENOM; CLU_081609_7_0_1; -.
DR   InParanoid; A0MTF4; -.
DR   OMA; TQVKYWP; -.
DR   OrthoDB; 1157770at2759; -.
DR   TreeFam; TF317805; -.
DR   Proteomes; UP000009136; Chromosome 6.
DR   Bgee; ENSBTAG00000017348; Expressed in oocyte and 19 other tissues.
DR   ExpressionAtlas; A0MTF4; baseline.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0010001; P:glial cell differentiation; IEA:Ensembl.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR   GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR   GO; GO:0023019; P:signal transduction involved in regulation of gene expression; IEA:Ensembl.
DR   CDD; cd00058; FGF; 1.
DR   InterPro; IPR028240; FGF5.
DR   InterPro; IPR002209; Fibroblast_GF_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR11486; PTHR11486; 1.
DR   PANTHER; PTHR11486:SF23; PTHR11486:SF23; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00263; HBGFFGF.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Growth factor; Mitogen; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..270
FT                   /note="Fibroblast growth factor 5"
FT                   /id="PRO_0000279863"
FT   REGION          25..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          237..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        42..86
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        112
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   270 AA;  29641 MW;  9B23BF010B3BD49D CRC64;
     MSLSFLLLLF LSHLILSAWA QGEKRLAPKG QPGPAATERN PGGASSRRSS SSTATSSSSP
     ASSSSAASRG GPGSSLEQSS FQWSPSGRRT GSLYCRVGIG FHLQIYPDGK VNGSHEANML
     SILEIFAVSQ GIVGIRGVFS NKFLAMSKKG KLHASAKFTD DCKFRERFQE NSYNTYASAI
     HRTEKTGREW YVALNKRGKA KRGCSPRVKP QHVSTHFLPR FKQLEQPELS FTVTVPEKKK
     PPNPVKPKVP LSAPRRSPNT VKYRLKFRFG