FGF5_FELCA
ID FGF5_FELCA Reviewed; 270 AA.
AC M3X9S6; A2AXN8; A2AXN9;
DT 07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2013, sequence version 1.
DT 03-AUG-2022, entry version 55.
DE RecName: Full=Fibroblast growth factor 5;
DE Short=FGF-5;
DE Flags: Precursor;
GN Name=FGF5;
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), VARIANTS
RP ASP-61; PRO-65 AND PRO-159, POLYMORPHISM, AND TISSUE SPECIFICITY.
RX PubMed=17433015; DOI=10.1111/j.1365-2052.2007.01590.x;
RA Drogemuller C., Rufenacht S., Wichert B., Leeb T.;
RT "Mutations within the FGF5 gene are associated with hair length in cats.";
RL Anim. Genet. 38:218-221(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian;
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [3]
RP POLYMORPHISM, AND IDENTIFICATION OF VARIANTS SER-51; ASP-61; PRO-65;
RP 136-ARG--GLY-270 DEL AND PRO-159.
RX PubMed=17767004; DOI=10.1093/jhered/esm072;
RA Kehler J.S., David V.A., Schaeffer A.A., Bajema K., Eizirik E., Ryugo D.K.,
RA Hannah S.S., O'Brien S.J., Menotti-Raymond M.;
RT "Four independent mutations in the feline fibroblast growth factor 5 gene
RT determine the long-haired phenotype in domestic cats.";
RL J. Hered. 98:555-566(2007).
CC -!- FUNCTION: Plays an important role in the regulation of cell
CC proliferation and cell differentiation. Required for normal regulation
CC of the hair growth cycle. Functions as an inhibitor of hair elongation
CC by promoting progression from anagen, the growth phase of the hair
CC follicle, into catagen the apoptosis-induced regression phase (By
CC similarity). {ECO:0000250|UniProtKB:P12034,
CC ECO:0000250|UniProtKB:Q20FD0}.
CC -!- SUBUNIT: Interacts with FGFR1 and FGFR2. Affinity between fibroblast
CC growth factors (FGFs) and their receptors is increased by heparan
CC sulfate glycosaminoglycans that function as coreceptors.
CC {ECO:0000250|UniProtKB:P12034}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=M3X9S6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=M3X9S6-2; Sequence=VSP_060955, VSP_060956;
CC -!- TISSUE SPECIFICITY: [Isoform 1]: Expressed in skin.
CC {ECO:0000269|PubMed:17433015}.
CC -!- TISSUE SPECIFICITY: [Isoform 2]: Expressed in skin.
CC {ECO:0000269|PubMed:17433015}.
CC -!- POLYMORPHISM: Allelic variations in FGF5 may be associated with long-
CC haired phenotype in domestic cats. The trait is autosomal recessive.
CC {ECO:0000269|PubMed:17433015, ECO:0000269|PubMed:17767004}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; AM412646; CAL81525.1; -; Genomic_DNA.
DR EMBL; AM412646; CAL91036.1; -; Genomic_DNA.
DR EMBL; AM412647; CAL81526.2; -; mRNA.
DR EMBL; AM412648; CAL81527.2; -; mRNA.
DR EMBL; AANG04001605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001108018.1; NM_001114546.1.
DR RefSeq; XP_006931094.1; XM_006931032.2. [M3X9S6-2]
DR AlphaFoldDB; M3X9S6; -.
DR SMR; M3X9S6; -.
DR STRING; 9685.ENSFCAP00000023379; -.
DR Ensembl; ENSFCAT00000030948; ENSFCAP00000023379; ENSFCAG00000029635. [M3X9S6-1]
DR GeneID; 100136904; -.
DR KEGG; fca:100136904; -.
DR CTD; 2250; -.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000158449; -.
DR HOGENOM; CLU_081609_7_0_1; -.
DR InParanoid; M3X9S6; -.
DR OMA; TQVKYWP; -.
DR OrthoDB; 1157770at2759; -.
DR Proteomes; UP000011712; Chromosome B1.
DR Bgee; ENSFCAG00000029635; Expressed in zone of skin and 3 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:InterPro.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028240; FGF5.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF23; PTHR11486:SF23; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Growth factor; Mitogen;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..270
FT /note="Fibroblast growth factor 5"
FT /evidence="ECO:0000255"
FT /id="PRO_5005140408"
FT REGION 26..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 112
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 122..125
FT /note="ILEI -> QIYR (in isoform 2)"
FT /id="VSP_060955"
FT VAR_SEQ 126..270
FT /note="Missing (in isoform 2)"
FT /id="VSP_060956"
FT VARIANT 51
FT /note="R -> S"
FT /evidence="ECO:0000269|PubMed:17767004"
FT VARIANT 61
FT /note="V -> D"
FT /evidence="ECO:0000269|PubMed:17433015,
FT ECO:0000269|PubMed:17767004"
FT VARIANT 65
FT /note="H -> P"
FT /evidence="ECO:0000269|PubMed:17433015,
FT ECO:0000269|PubMed:17767004"
FT VARIANT 136..270
FT /note="Missing (associated with long-haired phenotype)"
FT /evidence="ECO:0000269|PubMed:17767004"
FT VARIANT 159
FT /note="T -> P (associated with long-haired phenotype)"
FT /evidence="ECO:0000269|PubMed:17433015,
FT ECO:0000269|PubMed:17767004"
SQ SEQUENCE 270 AA; 29556 MW; 31823593D07CF6B5 CRC64;
MSLSFLLLLF LSHLILSAWA HGEKHLAPKG QPGPAATGRN PAGASSSRSS RGTTSSSSSS
VSSSHSASLG NQGSGLEQSS FQWSPSGRRT GSLYCRVGIG FHLQIYPDGK VNGSHEANML
SILEIFAVSQ GIVGIRGVFS NKFLAMSKKG KLHASAKFTD DCKFRERFQE NSYNTYASAI
HRTEPAGREW YVALNKRGKA KRGCSPRVKP QHISTHFLPR FKQLEQPELS FTVTVPEKKK
PPSPVKPKVP LSAPRKSPNT VKYRLKFRFG
