FGF6_MOUSE
ID FGF6_MOUSE Reviewed; 208 AA.
AC P21658;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Fibroblast growth factor 6;
DE Short=FGF-6;
DE AltName: Full=Heparin secretory-transforming protein 2;
DE Short=HST-2;
DE Short=HSTF-2;
DE AltName: Full=Heparin-binding growth factor 6;
DE Short=HBGF-6;
DE Flags: Precursor;
GN Name=Fgf6; Synonyms=Fgf-6, Hstf2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC TISSUE=Embryo;
RX PubMed=1477139; DOI=10.1016/0300-9084(92)90025-a;
RA Ollendorf V., Rosnet O., Marics I., Birnbaum D., Delapeyriere O.;
RT "Isolation and sequence of the murine Fgf6 cDNA.";
RL Biochimie 74:1035-1038(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 11-208.
RX PubMed=2193291;
RA de Lapeyriere O., Rosnet O., Benharroch D., Raybaud F., Marchetto S.,
RA Planche J., Galland F., Mattei M.-G., Copeland N.G., Jenkins N.A.,
RA Coulier F., Birnbaum D.;
RT "Structure, chromosome mapping and expression of the murine Fgf-6 gene.";
RL Oncogene 5:823-831(1990).
CC -!- FUNCTION: Plays an important role in the regulation of cell
CC proliferation, cell differentiation, angiogenesis and myogenesis, and
CC is required for normal muscle regeneration. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with FGFR1, FGFR2 and FGFR4. Affinity between
CC fibroblast growth factors (FGFs) and their receptors is increased by
CC heparan sulfate glycosaminoglycans that function as coreceptors (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space.
CC -!- TISSUE SPECIFICITY: Embryos, adult muscles and adult testis.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; M92415; AAA62260.1; -; Genomic_DNA.
DR EMBL; M92416; AAA62261.1; -; mRNA.
DR EMBL; X51552; CAA35925.1; -; Genomic_DNA.
DR CCDS; CCDS20561.1; -.
DR PIR; S14192; S14192.
DR RefSeq; NP_034334.1; NM_010204.1.
DR AlphaFoldDB; P21658; -.
DR SMR; P21658; -.
DR STRING; 10090.ENSMUSP00000000187; -.
DR GlyGen; P21658; 1 site.
DR iPTMnet; P21658; -.
DR PhosphoSitePlus; P21658; -.
DR PaxDb; P21658; -.
DR PRIDE; P21658; -.
DR Antibodypedia; 41814; 193 antibodies from 22 providers.
DR DNASU; 14177; -.
DR Ensembl; ENSMUST00000000187; ENSMUSP00000000187; ENSMUSG00000000183.
DR GeneID; 14177; -.
DR KEGG; mmu:14177; -.
DR UCSC; uc009dvo.1; mouse.
DR CTD; 2251; -.
DR MGI; MGI:95520; Fgf6.
DR VEuPathDB; HostDB:ENSMUSG00000000183; -.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000157821; -.
DR HOGENOM; CLU_081609_4_1_1; -.
DR InParanoid; P21658; -.
DR OMA; RISGAHN; -.
DR OrthoDB; 1183051at2759; -.
DR PhylomeDB; P21658; -.
DR TreeFam; TF317805; -.
DR Reactome; R-MMU-109704; PI3K Cascade.
DR Reactome; R-MMU-1257604; PIP3 activates AKT signaling.
DR Reactome; R-MMU-190322; FGFR4 ligand binding and activation.
DR Reactome; R-MMU-190373; FGFR1c ligand binding and activation.
DR Reactome; R-MMU-190375; FGFR2c ligand binding and activation.
DR Reactome; R-MMU-5654219; Phospholipase C-mediated cascade: FGFR1.
DR Reactome; R-MMU-5654221; Phospholipase C-mediated cascade, FGFR2.
DR Reactome; R-MMU-5654228; Phospholipase C-mediated cascade, FGFR4.
DR Reactome; R-MMU-5654687; Downstream signaling of activated FGFR1.
DR Reactome; R-MMU-5654688; SHC-mediated cascade:FGFR1.
DR Reactome; R-MMU-5654689; PI-3K cascade:FGFR1.
DR Reactome; R-MMU-5654693; FRS-mediated FGFR1 signaling.
DR Reactome; R-MMU-5654695; PI-3K cascade:FGFR2.
DR Reactome; R-MMU-5654699; SHC-mediated cascade:FGFR2.
DR Reactome; R-MMU-5654700; FRS-mediated FGFR2 signaling.
DR Reactome; R-MMU-5654712; FRS-mediated FGFR4 signaling.
DR Reactome; R-MMU-5654719; SHC-mediated cascade:FGFR4.
DR Reactome; R-MMU-5654720; PI-3K cascade:FGFR4.
DR Reactome; R-MMU-5654726; Negative regulation of FGFR1 signaling.
DR Reactome; R-MMU-5654727; Negative regulation of FGFR2 signaling.
DR Reactome; R-MMU-5654733; Negative regulation of FGFR4 signaling.
DR Reactome; R-MMU-5673001; RAF/MAP kinase cascade.
DR Reactome; R-MMU-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR BioGRID-ORCS; 14177; 0 hits in 73 CRISPR screens.
DR PRO; PR:P21658; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P21658; protein.
DR Bgee; ENSMUSG00000000183; Expressed in mesenchyme of tongue and 42 other tissues.
DR Genevisible; P21658; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0042383; C:sarcolemma; ISO:MGI.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0001502; P:cartilage condensation; IGI:MGI.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; ISO:MGI.
DR GO; GO:0045445; P:myoblast differentiation; IDA:MGI.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028242; FGF6.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF25; PTHR11486:SF25; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Angiogenesis; Developmental protein; Differentiation; Disulfide bond;
KW Glycoprotein; Growth factor; Mitogen; Proto-oncogene; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..37
FT /evidence="ECO:0000255"
FT CHAIN 38..208
FT /note="Fibroblast growth factor 6"
FT /id="PRO_0000008962"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 90..157
FT /evidence="ECO:0000255"
SQ SEQUENCE 208 AA; 22798 MW; BBF7B9301BB79A1B CRC64;
MALGQRLFIT MSRGAGRVQG TLQALVFLGV LVGMVVPSPA GARANGTLLD SRGWGTLLSR
SRAGLAGEIS GVNWESGYLV GIKRQRRLYC NVGIGFHLQV PPDGRISGTH EENPYSLLEI
STVERGVVSL FGVKSALFIA MNSKGRLYTT PSFHDECKFR ETLLPNNYNA YESDLYRGTY
IALSKYGRVK RGSKVSPIMT VTHFLPRI
