FGF7_CANLF
ID FGF7_CANLF Reviewed; 194 AA.
AC P79150;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Fibroblast growth factor 7;
DE Short=FGF-7;
DE AltName: Full=Heparin-binding growth factor 7;
DE Short=HBGF-7;
DE AltName: Full=Keratinocyte growth factor;
DE Flags: Precursor;
GN Name=FGF7; Synonyms=KGF;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8634153; DOI=10.1089/dna.1996.15.247;
RA Canatan H., Chang W.Y., Sugimoto Y., Shidaifat F., Kulp S.K.,
RA Brueggemeier R.W., Lin Y.C.;
RT "Keratinocyte growth factor (KGF/FGF-7) has a paracrine role in canine
RT prostate: molecular cloning of mRNA encoding canine KGF.";
RL DNA Cell Biol. 15:247-254(1996).
CC -!- FUNCTION: Plays an important role in the regulation of embryonic
CC development, cell proliferation and cell differentiation. Required for
CC normal branching morphogenesis. Growth factor active on keratinocytes.
CC Possible major paracrine effector of normal epithelial cell
CC proliferation (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with FGFBP1. Interacts with FGFR2. Affinity between
CC fibroblast growth factors (FGFs) and their receptors is increased by
CC heparan sulfate glycosaminoglycans that function as coreceptors (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; U80800; AAB38972.1; -; mRNA.
DR RefSeq; NP_001003237.1; NM_001003237.1.
DR RefSeq; XP_005638232.1; XM_005638175.2.
DR AlphaFoldDB; P79150; -.
DR SMR; P79150; -.
DR STRING; 9615.ENSCAFP00000021986; -.
DR PaxDb; P79150; -.
DR Ensembl; ENSCAFT00030013677; ENSCAFP00030011936; ENSCAFG00030007447.
DR Ensembl; ENSCAFT00040036077; ENSCAFP00040031417; ENSCAFG00040019496.
DR Ensembl; ENSCAFT00845039189; ENSCAFP00845030694; ENSCAFG00845022021.
DR GeneID; 403915; -.
DR KEGG; cfa:403915; -.
DR CTD; 2252; -.
DR VEuPathDB; HostDB:ENSCAFG00845022021; -.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00950000183187; -.
DR HOGENOM; CLU_081609_3_1_1; -.
DR InParanoid; P79150; -.
DR OMA; QYYICMN; -.
DR OrthoDB; 1153514at2759; -.
DR TreeFam; TF317805; -.
DR Reactome; R-CFA-109704; PI3K Cascade.
DR Reactome; R-CFA-1257604; PIP3 activates AKT signaling.
DR Reactome; R-CFA-190377; FGFR2b ligand binding and activation.
DR Reactome; R-CFA-5654221; Phospholipase C-mediated cascade, FGFR2.
DR Reactome; R-CFA-5654695; PI-3K cascade:FGFR2.
DR Reactome; R-CFA-5654699; SHC-mediated cascade:FGFR2.
DR Reactome; R-CFA-5654700; FRS-mediated FGFR2 signaling.
DR Reactome; R-CFA-5654727; Negative regulation of FGFR2 signaling.
DR Reactome; R-CFA-5673001; RAF/MAP kinase cascade.
DR Reactome; R-CFA-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR Proteomes; UP000002254; Chromosome 30.
DR Bgee; ENSCAFG00000014923; Expressed in bone marrow and 45 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0042056; F:chemoattractant activity; IEA:Ensembl.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0005111; F:type 2 fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0031532; P:actin cytoskeleton reorganization; IEA:Ensembl.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0060445; P:branching involved in salivary gland morphogenesis; IEA:Ensembl.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0001935; P:endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0031069; P:hair follicle morphogenesis; IEA:Ensembl.
DR GO; GO:0030324; P:lung development; IBA:GO_Central.
DR GO; GO:0010463; P:mesenchymal cell proliferation; IEA:Ensembl.
DR GO; GO:0051450; P:myoblast proliferation; IEA:Ensembl.
DR GO; GO:0050918; P:positive chemotaxis; IBA:GO_Central.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IBA:GO_Central.
DR GO; GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0051549; P:positive regulation of keratinocyte migration; IEA:Ensembl.
DR GO; GO:0010838; P:positive regulation of keratinocyte proliferation; IEA:Ensembl.
DR GO; GO:2000288; P:positive regulation of myoblast proliferation; IEA:Ensembl.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0034394; P:protein localization to cell surface; IEA:Ensembl.
DR GO; GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; IEA:Ensembl.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR GO; GO:0061033; P:secretion by lung epithelial cell involved in lung growth; IEA:Ensembl.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028247; FGF7.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF20; PTHR11486:SF20; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Growth factor; Heparin-binding; Mitogen; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..31
FT /evidence="ECO:0000250"
FT CHAIN 32..194
FT /note="Fibroblast growth factor 7"
FT /id="PRO_0000008963"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 194 AA; 22476 MW; 8B4E56304B8F14D6 CRC64;
MRKWILTWIL PTLLYRSCFH IICLVGTISL ACNDMTPEQM ATNVNCSSPE RHTRSYDYME
GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNSYNIMEI RTVAVGIVAI KGVESEYYLA
MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHSG GEMFVALNQK GVPVRGKKTK
KEQKTAHFLP MAIT
