FGF7_MOUSE
ID FGF7_MOUSE Reviewed; 194 AA.
AC P36363;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 168.
DE RecName: Full=Fibroblast growth factor 7;
DE Short=FGF-7;
DE AltName: Full=Heparin-binding growth factor 7;
DE Short=HBGF-7;
DE AltName: Full=Keratinocyte growth factor;
DE Short=KGF;
DE Flags: Precursor;
GN Name=Fgf7; Synonyms=Fgf-7, Kgf;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8186145; DOI=10.1016/0925-4773(94)90050-7;
RA Mason I.J., Fuller-Pace F., Smith R., Dickson C.;
RT "FGF-7 (keratinocyte growth factor) expression during mouse development
RT suggests roles in myogenesis, forebrain regionalisation and epithelial-
RT mesenchymal interactions.";
RL Mech. Dev. 45:15-30(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=FVB/N;
RA Jones M.L., Dato M.E., Greenberg J.M.;
RL Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C3H/He; TISSUE=Osteoblast;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays an important role in the regulation of embryonic
CC development, cell proliferation and cell differentiation. Required for
CC normal branching morphogenesis. Growth factor active on keratinocytes.
CC Possible major paracrine effector of normal epithelial cell
CC proliferation (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with FGFBP1. Interacts with FGFR2. Affinity between
CC fibroblast growth factors (FGFs) and their receptors is increased by
CC heparan sulfate glycosaminoglycans that function as coreceptors (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; Z22703; CAA80403.1; -; mRNA.
DR EMBL; U58503; AAB01343.1; -; Genomic_DNA.
DR EMBL; BC052847; AAH52847.1; -; mRNA.
DR CCDS; CCDS16681.1; -.
DR PIR; I48610; I48610.
DR RefSeq; NP_032034.1; NM_008008.4.
DR AlphaFoldDB; P36363; -.
DR SMR; P36363; -.
DR BioGRID; 199652; 1.
DR IntAct; P36363; 1.
DR STRING; 10090.ENSMUSP00000069681; -.
DR GlyGen; P36363; 1 site.
DR iPTMnet; P36363; -.
DR PhosphoSitePlus; P36363; -.
DR PaxDb; P36363; -.
DR PRIDE; P36363; -.
DR ProteomicsDB; 271754; -.
DR Antibodypedia; 12143; 402 antibodies from 35 providers.
DR DNASU; 14178; -.
DR Ensembl; ENSMUST00000064794; ENSMUSP00000069681; ENSMUSG00000027208.
DR Ensembl; ENSMUST00000110442; ENSMUSP00000106072; ENSMUSG00000027208.
DR GeneID; 14178; -.
DR KEGG; mmu:14178; -.
DR UCSC; uc008mdj.2; mouse.
DR CTD; 2252; -.
DR MGI; MGI:95521; Fgf7.
DR VEuPathDB; HostDB:ENSMUSG00000027208; -.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000159843; -.
DR HOGENOM; CLU_081609_3_1_1; -.
DR InParanoid; P36363; -.
DR OMA; QYYICMN; -.
DR OrthoDB; 1340221at2759; -.
DR PhylomeDB; P36363; -.
DR TreeFam; TF317805; -.
DR Reactome; R-MMU-109704; PI3K Cascade.
DR Reactome; R-MMU-1257604; PIP3 activates AKT signaling.
DR Reactome; R-MMU-190377; FGFR2b ligand binding and activation.
DR Reactome; R-MMU-5654221; Phospholipase C-mediated cascade, FGFR2.
DR Reactome; R-MMU-5654695; PI-3K cascade:FGFR2.
DR Reactome; R-MMU-5654699; SHC-mediated cascade:FGFR2.
DR Reactome; R-MMU-5654700; FRS-mediated FGFR2 signaling.
DR Reactome; R-MMU-5654727; Negative regulation of FGFR2 signaling.
DR Reactome; R-MMU-5673001; RAF/MAP kinase cascade.
DR Reactome; R-MMU-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR BioGRID-ORCS; 14178; 1 hit in 71 CRISPR screens.
DR PRO; PR:P36363; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P36363; protein.
DR Bgee; ENSMUSG00000027208; Expressed in mesenchyme of tongue and 216 other tissues.
DR ExpressionAtlas; P36363; baseline and differential.
DR Genevisible; P36363; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0005794; C:Golgi apparatus; IDA:MGI.
DR GO; GO:0042056; F:chemoattractant activity; ISO:MGI.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; ISO:MGI.
DR GO; GO:0008201; F:heparin binding; ISO:MGI.
DR GO; GO:0005111; F:type 2 fibroblast growth factor receptor binding; ISO:MGI.
DR GO; GO:0031532; P:actin cytoskeleton reorganization; ISO:MGI.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0060445; P:branching involved in salivary gland morphogenesis; IDA:MGI.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0001935; P:endothelial cell proliferation; IDA:MGI.
DR GO; GO:0050673; P:epithelial cell proliferation; IDA:MGI.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; ISO:MGI.
DR GO; GO:0031069; P:hair follicle morphogenesis; IMP:MGI.
DR GO; GO:0030324; P:lung development; ISO:MGI.
DR GO; GO:0010463; P:mesenchymal cell proliferation; ISO:MGI.
DR GO; GO:0051450; P:myoblast proliferation; IDA:MGI.
DR GO; GO:0001541; P:ovarian follicle development; ISO:MGI.
DR GO; GO:0006656; P:phosphatidylcholine biosynthetic process; ISO:MGI.
DR GO; GO:0008654; P:phospholipid biosynthetic process; ISO:MGI.
DR GO; GO:0050918; P:positive chemotaxis; ISO:MGI.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IDA:MGI.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IDA:MGI.
DR GO; GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis; ISO:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0051549; P:positive regulation of keratinocyte migration; ISO:MGI.
DR GO; GO:0010838; P:positive regulation of keratinocyte proliferation; ISO:MGI.
DR GO; GO:2000288; P:positive regulation of myoblast proliferation; IDA:MGI.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISO:MGI.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:CACAO.
DR GO; GO:0034394; P:protein localization to cell surface; ISO:MGI.
DR GO; GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; IDA:MGI.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR GO; GO:0061033; P:secretion by lung epithelial cell involved in lung growth; ISO:MGI.
DR GO; GO:0043129; P:surfactant homeostasis; ISO:MGI.
DR GO; GO:0042060; P:wound healing; ISO:MGI.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028247; FGF7.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF20; PTHR11486:SF20; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Growth factor; Heparin-binding; Mitogen; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..31
FT /evidence="ECO:0000250"
FT CHAIN 32..194
FT /note="Fibroblast growth factor 7"
FT /id="PRO_0000008966"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 194 AA; 22347 MW; 805C30D4B1D27C73 CRC64;
MRKWILTRIL PTLLYRSCFH LVCLVGTISL ACNDMSPEQT ATSVNCSSPE RHTRSYDYME
GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNSYNIMEI RTVAVGIVAI KGVESEYYLA
MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHSG GEMFVALNQK GIPVKGKKTK
KEQKTAHFLP MAIT
