ID   FGF7_PONAB              Reviewed;         194 AA.
AC   Q5RAY8;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Fibroblast growth factor 7;
DE            Short=FGF-7;
DE   AltName: Full=Heparin-binding growth factor 7;
DE            Short=HBGF-7;
DE   AltName: Full=Keratinocyte growth factor;
DE   Flags: Precursor;
GN   Name=FGF7; Synonyms=KGF;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the regulation of embryonic
CC       development, cell proliferation and cell differentiation. Required for
CC       normal branching morphogenesis. Growth factor active on keratinocytes.
CC       Possible major paracrine effector of normal epithelial cell
CC       proliferation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with FGFBP1. Interacts with FGFR2. Affinity between
CC       fibroblast growth factors (FGFs) and their receptors is increased by
CC       heparan sulfate glycosaminoglycans that function as coreceptors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC       {ECO:0000305}.
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DR   EMBL; CR858873; CAH91072.1; -; mRNA.
DR   RefSeq; NP_001125621.1; NM_001132149.1.
DR   AlphaFoldDB; Q5RAY8; -.
DR   SMR; Q5RAY8; -.
DR   Ensembl; ENSPPYT00000007627; ENSPPYP00000007325; ENSPPYG00000039648.
DR   GeneID; 100172539; -.
DR   KEGG; pon:100172539; -.
DR   CTD; 2252; -.
DR   GeneTree; ENSGT00940000159843; -.
DR   HOGENOM; CLU_081609_3_1_1; -.
DR   InParanoid; Q5RAY8; -.
DR   OrthoDB; 1340221at2759; -.
DR   Proteomes; UP000001595; Chromosome 15.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0042056; F:chemoattractant activity; IEA:Ensembl.
DR   GO; GO:0005104; F:fibroblast growth factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR   GO; GO:0031532; P:actin cytoskeleton reorganization; IEA:Ensembl.
DR   GO; GO:0060445; P:branching involved in salivary gland morphogenesis; IEA:Ensembl.
DR   GO; GO:0001935; P:endothelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0031069; P:hair follicle morphogenesis; IEA:Ensembl.
DR   GO; GO:0010463; P:mesenchymal cell proliferation; IEA:Ensembl.
DR   GO; GO:0051450; P:myoblast proliferation; IEA:Ensembl.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis; IEA:Ensembl.
DR   GO; GO:0051549; P:positive regulation of keratinocyte migration; IEA:Ensembl.
DR   GO; GO:0010838; P:positive regulation of keratinocyte proliferation; IEA:Ensembl.
DR   GO; GO:2000288; P:positive regulation of myoblast proliferation; IEA:Ensembl.
DR   GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0034394; P:protein localization to cell surface; IEA:Ensembl.
DR   GO; GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; IEA:Ensembl.
DR   GO; GO:0061033; P:secretion by lung epithelial cell involved in lung growth; IEA:Ensembl.
DR   CDD; cd00058; FGF; 1.
DR   InterPro; IPR028247; FGF7.
DR   InterPro; IPR002209; Fibroblast_GF_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR11486; PTHR11486; 1.
DR   PANTHER; PTHR11486:SF20; PTHR11486:SF20; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00263; HBGFFGF.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Growth factor; Heparin-binding; Mitogen; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..194
FT                   /note="Fibroblast growth factor 7"
FT                   /id="PRO_0000042933"
FT   CARBOHYD        45
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   194 AA;  22509 MW;  B19192474E6049E2 CRC64;
     MHKWILTWIL PTLLYRSCFH IICLVGTISL ACNDMTPEQM ATNVNCSSPE RHTRSYDYME
     GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEFYLA
     MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHNG GEMFVALNQK GIPVRGKKTK
     KEQKTAHFLP MAIT