ID   FGF7_SHEEP              Reviewed;         194 AA.
AC   P48808;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Fibroblast growth factor 7;
DE            Short=FGF-7;
DE   AltName: Full=Heparin-binding growth factor 7;
DE            Short=HBGF-7;
DE   AltName: Full=Keratinocyte growth factor;
DE   Flags: Precursor;
GN   Name=FGF7; Synonyms=KGF;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Mitchell J.E.A., McInnes C.J.;
RL   Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the regulation of embryonic
CC       development, cell proliferation and cell differentiation. Required for
CC       normal branching morphogenesis. Growth factor active on keratinocytes.
CC       Possible major paracrine effector of normal epithelial cell
CC       proliferation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with FGFBP1. Interacts with FGFR2. Affinity between
CC       fibroblast growth factors (FGFs) and their receptors is increased by
CC       heparan sulfate glycosaminoglycans that function as coreceptors (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC       {ECO:0000305}.
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DR   EMBL; Z46236; CAA86306.1; -; mRNA.
DR   PIR; S49501; S49501.
DR   AlphaFoldDB; P48808; -.
DR   SMR; P48808; -.
DR   STRING; 9940.ENSOARP00000022568; -.
DR   eggNOG; KOG3885; Eukaryota.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005104; F:fibroblast growth factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   CDD; cd00058; FGF; 1.
DR   InterPro; IPR028247; FGF7.
DR   InterPro; IPR002209; Fibroblast_GF_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR11486; PTHR11486; 1.
DR   PANTHER; PTHR11486:SF20; PTHR11486:SF20; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00263; HBGFFGF.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Growth factor; Heparin-binding; Mitogen; Reference proteome;
KW   Signal.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000250"
FT   CHAIN           32..194
FT                   /note="Fibroblast growth factor 7"
FT                   /id="PRO_0000008969"
FT   CARBOHYD        45
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   194 AA;  22448 MW;  80FAF4BC5B76F668 CRC64;
     MRKWILTWIL PSLLYRSCFH IICLVGTISL ACNDMTPEQM ATNVNCSSPE RHTRSYDYME
     GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEYYLA
     MNKEGKLYAK KECNEDCNFK ELILENHYNT YASAKWTHSG GEMFVALNSK GVPVRGKKTK
     KEQKTAHFLP MAIT