FGF8A_DANRE
ID FGF8A_DANRE Reviewed; 210 AA.
AC O57341; Q5PRC3;
DT 14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Fibroblast growth factor 8;
DE Short=FGF-8;
DE Flags: Precursor;
GN Name=fgf8a {ECO:0000312|ZFIN:ZDB-GENE-990415-72};
GN Synonyms=fgf-8 {ECO:0000312|EMBL:AAC60303.1},
GN fgf8 {ECO:0000312|ZFIN:ZDB-GENE-990415-72};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9334274; DOI=10.1242/dev.124.21.4253;
RA Fuerthauer M., Thisse C., Thisse B.;
RT "A role for FGF-8 in the dorsoventral patterning of the zebrafish
RT gastrula.";
RL Development 124:4253-4264(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9609821; DOI=10.1242/dev.125.13.2381;
RA Reifers F., Boehli H., Walsh E.C., Crossley P.H., Stanier D.Y.R., Brand M.;
RT "Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for
RT maintenance of midbrain-hindbrain boundary development and somitogenesis.";
RL Development 125:2381-2395(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Inoue F., Nagayoshi S., Ota S., Islam M.E., Tonou-Fujimori N., Odaira Y.,
RA Kikuta H., Kawakami K., Yamasu K.;
RT "Genomic organization, alternative splicing, and multiple regulatory
RT regions of the zebrafish fgf8 gene.";
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000312|Ensembl:ENSDARP00000018653,
RC ECO:0000312|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [6]
RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=19164561; DOI=10.1073/pnas.0812880106;
RA Hong S.K., Dawid I.B.;
RT "FGF-dependent left-right asymmetry patterning in zebrafish is mediated by
RT Ier2 and Fibp1.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:2230-2235(2009).
CC -!- FUNCTION: Plays an important role in the regulation of embryonic
CC development, cell proliferation, cell differentiation and cell
CC migration (By similarity). Required for Kupffer's vesicle ciliogenesis
CC (PubMed:19164561). {ECO:0000250|UniProtKB:P55075,
CC ECO:0000269|PubMed:19164561}.
CC -!- SUBUNIT: Monomer (By similarity). Homodimer (By similarity).
CC {ECO:0000250|UniProtKB:P55075}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P55075}.
CC -!- DEVELOPMENTAL STAGE: Expressed in Kupffer's vesicle.
CC {ECO:0000269|PubMed:19164561}.
CC -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein causes a
CC dramatic loss of cilia in Kupffer's vesicle.
CC {ECO:0000269|PubMed:19164561}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000255|RuleBase:RU049442}.
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DR EMBL; AF051365; AAC41302.1; -; mRNA.
DR EMBL; AF034264; AAC60303.1; -; mRNA.
DR EMBL; BC086718; AAH86718.1; -; mRNA.
DR EMBL; BC165018; AAI65018.1; -; mRNA.
DR EMBL; AB256522; BAF34588.1; -; Genomic_DNA.
DR EMBL; CR925797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_571356.2; NM_131281.2.
DR AlphaFoldDB; O57341; -.
DR SMR; O57341; -.
DR STRING; 7955.ENSDARP00000018653; -.
DR PaxDb; O57341; -.
DR Ensembl; ENSDART00000025583; ENSDARP00000018653; ENSDARG00000003399.
DR GeneID; 30538; -.
DR KEGG; dre:30538; -.
DR CTD; 30538; -.
DR ZFIN; ZDB-GENE-990415-72; fgf8a.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000159518; -.
DR InParanoid; O57341; -.
DR OrthoDB; 1190450at2759; -.
DR PhylomeDB; O57341; -.
DR TreeFam; TF331233; -.
DR Reactome; R-DRE-109704; PI3K Cascade.
DR Reactome; R-DRE-1257604; PIP3 activates AKT signaling.
DR Reactome; R-DRE-190322; FGFR4 ligand binding and activation.
DR Reactome; R-DRE-190371; FGFR3b ligand binding and activation.
DR Reactome; R-DRE-190372; FGFR3c ligand binding and activation.
DR Reactome; R-DRE-190373; FGFR1c ligand binding and activation.
DR Reactome; R-DRE-190375; FGFR2c ligand binding and activation.
DR Reactome; R-DRE-5654219; Phospholipase C-mediated cascade: FGFR1.
DR Reactome; R-DRE-5654221; Phospholipase C-mediated cascade, FGFR2.
DR Reactome; R-DRE-5654227; Phospholipase C-mediated cascade, FGFR3.
DR Reactome; R-DRE-5654228; Phospholipase C-mediated cascade, FGFR4.
DR Reactome; R-DRE-5654687; Downstream signaling of activated FGFR1.
DR Reactome; R-DRE-5654688; SHC-mediated cascade:FGFR1.
DR Reactome; R-DRE-5654689; PI-3K cascade:FGFR1.
DR Reactome; R-DRE-5654693; FRS-mediated FGFR1 signaling.
DR Reactome; R-DRE-5654695; PI-3K cascade:FGFR2.
DR Reactome; R-DRE-5654699; SHC-mediated cascade:FGFR2.
DR Reactome; R-DRE-5654700; FRS-mediated FGFR2 signaling.
DR Reactome; R-DRE-5654704; SHC-mediated cascade:FGFR3.
DR Reactome; R-DRE-5654706; FRS-mediated FGFR3 signaling.
DR Reactome; R-DRE-5654710; PI-3K cascade:FGFR3.
DR Reactome; R-DRE-5654712; FRS-mediated FGFR4 signaling.
DR Reactome; R-DRE-5654719; SHC-mediated cascade:FGFR4.
DR Reactome; R-DRE-5654720; PI-3K cascade:FGFR4.
DR Reactome; R-DRE-5654726; Negative regulation of FGFR1 signaling.
DR Reactome; R-DRE-5654727; Negative regulation of FGFR2 signaling.
DR Reactome; R-DRE-5654732; Negative regulation of FGFR3 signaling.
DR Reactome; R-DRE-5654733; Negative regulation of FGFR4 signaling.
DR Reactome; R-DRE-5658623; FGFRL1 modulation of FGFR1 signaling.
DR Reactome; R-DRE-5673001; RAF/MAP kinase cascade.
DR Reactome; R-DRE-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR SignaLink; O57341; -.
DR PRO; PR:O57341; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 13.
DR Bgee; ENSDARG00000003399; Expressed in regional part of brain and 175 other tissues.
DR ExpressionAtlas; O57341; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IDA:ZFIN.
DR GO; GO:0005764; C:lysosome; IDA:ZFIN.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0005105; F:type 1 fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0005111; F:type 2 fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IMP:ZFIN.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IMP:ZFIN.
DR GO; GO:0007420; P:brain development; IMP:ZFIN.
DR GO; GO:0003208; P:cardiac ventricle morphogenesis; IMP:ZFIN.
DR GO; GO:0010002; P:cardioblast differentiation; IMP:ZFIN.
DR GO; GO:0051216; P:cartilage development; IMP:ZFIN.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0001708; P:cell fate specification; IMP:ZFIN.
DR GO; GO:0021549; P:cerebellum development; IMP:ZFIN.
DR GO; GO:0021588; P:cerebellum formation; IMP:ZFIN.
DR GO; GO:0060271; P:cilium assembly; IMP:ZFIN.
DR GO; GO:0061386; P:closure of optic fissure; IGI:ZFIN.
DR GO; GO:0048263; P:determination of dorsal identity; IDA:ZFIN.
DR GO; GO:0007368; P:determination of left/right symmetry; IMP:ZFIN.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IDA:ZFIN.
DR GO; GO:0060788; P:ectodermal placode formation; IMP:ZFIN.
DR GO; GO:0031076; P:embryonic camera-type eye development; IMP:ZFIN.
DR GO; GO:0035050; P:embryonic heart tube development; IGI:ZFIN.
DR GO; GO:0048702; P:embryonic neurocranium morphogenesis; IGI:ZFIN.
DR GO; GO:0009880; P:embryonic pattern specification; IGI:ZFIN.
DR GO; GO:0060059; P:embryonic retina morphogenesis in camera-type eye; IGI:ZFIN.
DR GO; GO:0007492; P:endoderm development; IDA:ZFIN.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0003007; P:heart morphogenesis; IMP:ZFIN.
DR GO; GO:0030902; P:hindbrain development; IMP:ZFIN.
DR GO; GO:0048839; P:inner ear development; IMP:ZFIN.
DR GO; GO:0070121; P:Kupffer's vesicle development; IMP:ZFIN.
DR GO; GO:0021703; P:locus ceruleus development; IMP:ZFIN.
DR GO; GO:0007498; P:mesoderm development; IGI:ZFIN.
DR GO; GO:0030901; P:midbrain development; IMP:ZFIN.
DR GO; GO:0030917; P:midbrain-hindbrain boundary development; IMP:ZFIN.
DR GO; GO:0021555; P:midbrain-hindbrain boundary morphogenesis; IGI:ZFIN.
DR GO; GO:0042664; P:negative regulation of endodermal cell fate specification; IDA:ZFIN.
DR GO; GO:0030182; P:neuron differentiation; IMP:ZFIN.
DR GO; GO:0048665; P:neuron fate specification; IGI:ZFIN.
DR GO; GO:0030903; P:notochord development; IGI:ZFIN.
DR GO; GO:0048709; P:oligodendrocyte differentiation; IGI:ZFIN.
DR GO; GO:0043049; P:otic placode formation; IMP:ZFIN.
DR GO; GO:0071599; P:otic vesicle development; IGI:ZFIN.
DR GO; GO:0030916; P:otic vesicle formation; IDA:ZFIN.
DR GO; GO:0048339; P:paraxial mesoderm development; IGI:ZFIN.
DR GO; GO:0007422; P:peripheral nervous system development; IGI:ZFIN.
DR GO; GO:0060037; P:pharyngeal system development; IGI:ZFIN.
DR GO; GO:0030335; P:positive regulation of cell migration; IGI:ZFIN.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0014709; P:positive regulation of somitomeric trunk muscle development; IMP:BHF-UCL.
DR GO; GO:0030177; P:positive regulation of Wnt signaling pathway; IGI:ZFIN.
DR GO; GO:0046850; P:regulation of bone remodeling; IMP:ZFIN.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR GO; GO:0060041; P:retina development in camera-type eye; IGI:ZFIN.
DR GO; GO:0021571; P:rhombomere 5 development; IGI:ZFIN.
DR GO; GO:0021572; P:rhombomere 6 development; IGI:ZFIN.
DR GO; GO:0048705; P:skeletal system morphogenesis; IMP:ZFIN.
DR GO; GO:0061053; P:somite development; IMP:ZFIN.
DR GO; GO:0001756; P:somitogenesis; IGI:ZFIN.
DR GO; GO:0051146; P:striated muscle cell differentiation; IMP:ZFIN.
DR GO; GO:0061195; P:taste bud formation; IMP:ZFIN.
DR GO; GO:0030878; P:thyroid gland development; IMP:ZFIN.
DR GO; GO:0055012; P:ventricular cardiac muscle cell differentiation; IMP:ZFIN.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028249; FGF8.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF3; PTHR11486:SF3; 1.
DR Pfam; PF00167; FGF; 1.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255|RuleBase:RU049442"
FT CHAIN 28..210
FT /note="Fibroblast growth factor 8"
FT /evidence="ECO:0000255|RuleBase:RU049442"
FT /id="PRO_5001419816"
FT CONFLICT 83
FT /note="H -> C (in Ref. 3; AAH86718/AAI65018)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 210 AA; 24697 MW; 9D9CA5B8E18A435A CRC64;
MRLIPSRLSY LFLHLFAFCY YAQVTIQSPP NFTQHVSEQS KVTDRVSRRL IRTYQLYSRT
SGKHVQVLAN KKINAMAEDG DVHAKLIVET DTFGSRVRIK GAETGFYICM NRRGKLIGKK
NGLGKDCIFT EIVLENNYTA LQNVKYEGWY MAFTRKGRPR KGSKTRQHQR EVHFMKRLPK
GHQIAEHRPF DFINYPFNRR TKRTRYSGER
