FGF8B_DANRE
ID FGF8B_DANRE Reviewed; 212 AA.
AC Q805B2;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Fibroblast growth factor 8b;
DE Short=FGF-8b;
DE AltName: Full=Fibroblast growth factor 17a;
DE Short=FGF-17a;
DE Flags: Precursor;
GN Name=fgf8b; Synonyms=fgf17 {ECO:0000312|EMBL:BAC55316.1}, fgf17a;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAC55316.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo {ECO:0000269|PubMed:11091072};
RX PubMed=11091072; DOI=10.1016/s0925-4773(00)00475-5;
RA Reifers F., Adams J., Mason I.J., Schulte-Merker S., Brand M.;
RT "Overlapping and distinct functions provided by fgf17, a new zebrafish
RT member of the Fgf8/17/18 subgroup of Fgfs.";
RL Mech. Dev. 99:39-49(2000).
CC -!- FUNCTION: May act as signaling molecule during development of the
CC midbrain-hindbrain boundary (MHB) organizer, and be involved in
CC patterning of the nervous system. {ECO:0000269|PubMed:11091072}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O60258}.
CC -!- DEVELOPMENTAL STAGE: Not expressed during gastrulation. First detected
CC at the 8-somite stage in the ventral region of the MHB and in the
CC anterior somites. At the 14-somite stage, expressed in the anteromedial
CC margins of the somites and in the optic stalks. At 24 hours, expression
CC is lost in the somites but observed in the otic vesicle. At 30 hours,
CC expressed in the hyoid and at 36 hours in the dorsal diencephalon.
CC {ECO:0000269|PubMed:11091072}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000255}.
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DR EMBL; AB100171; BAC55316.1; -; mRNA.
DR RefSeq; NP_878276.1; NM_182856.1.
DR AlphaFoldDB; Q805B2; -.
DR SMR; Q805B2; -.
DR STRING; 7955.ENSDARP00000057884; -.
DR PaxDb; Q805B2; -.
DR Ensembl; ENSDART00000057885; ENSDARP00000057884; ENSDARG00000039615.
DR GeneID; 65089; -.
DR KEGG; dre:65089; -.
DR CTD; 65089; -.
DR ZFIN; ZDB-GENE-010122-1; fgf8b.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000159518; -.
DR HOGENOM; CLU_090682_0_0_1; -.
DR InParanoid; Q805B2; -.
DR OrthoDB; 1190450at2759; -.
DR PhylomeDB; Q805B2; -.
DR TreeFam; TF331233; -.
DR PRO; PR:Q805B2; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 1.
DR Bgee; ENSDARG00000039615; Expressed in midbrain-hindbrain boundary and 17 other tissues.
DR ExpressionAtlas; Q805B2; baseline.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0005105; F:type 1 fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0005111; F:type 2 fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0009953; P:dorsal/ventral pattern formation; IBA:GO_Central.
DR GO; GO:0035050; P:embryonic heart tube development; IBA:GO_Central.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0003007; P:heart morphogenesis; IBA:GO_Central.
DR GO; GO:0030917; P:midbrain-hindbrain boundary development; NAS:UniProtKB.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0007389; P:pattern specification process; NAS:UniProtKB.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028249; FGF8.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF143; PTHR11486:SF143; 1.
DR Pfam; PF00167; FGF; 1.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Glycoprotein; Growth factor;
KW Mitogen; Neurogenesis; Reference proteome; Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..212
FT /note="Fibroblast growth factor 8b"
FT /id="PRO_0000008988"
FT CARBOHYD 139
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 212 AA; 24975 MW; 9CED1C82236C3C14 CRC64;
MRLKSSRLGY LFLQFMTLCF YTQMTMQSIS MPNFKHHVTE QSRLSDRMSR RLTRTYQLYS
RTSGKHVQVL GNKRVNANAE DGDIHAKLVV ETDTFGSRVR IRGAKTGYYI CMNKKGKLIG
RRKGRGKDCI FTEIVLENNY TALQNAKYKG WYMAFTRKGR PRKAMQTRQH QREAHFMKRL
PRGHLLTEQK PFDLIPYPLN KRTKHHQRAS VN
