ID   FGF8_CANLF              Reviewed;          82 AA.
AC   O62682;
DT   11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Fibroblast growth factor 8;
DE            Short=FGF-8;
DE   AltName: Full=Androgen-induced growth factor;
DE            Short=AIGF;
DE   AltName: Full=Heparin-binding growth factor 8;
DE            Short=HBGF-8;
DE   Flags: Fragment;
GN   Name=FGF8;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615 {ECO:0000312|EMBL:AAC17218.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Prostate, and Testis;
RX   PubMed=9590499; DOI=10.1007/s11626-998-0002-4;
RA   Canatan H., Lin Y.C.;
RT   "Nucleotide sequence of canine fibroblast growth factor-8 (FGF-8).";
RL   In Vitro Cell. Dev. Biol. Anim. 34:278-279(1998).
CC   -!- FUNCTION: Plays an important role in the regulation of embryonic
CC       development, cell proliferation, cell differentiation and cell
CC       migration. Required for normal brain, eye, ear and limb development
CC       during embryogenesis. Required for normal development of the
CC       gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in
CC       neurite outgrowth in hippocampal cells (By similarity).
CC       {ECO:0000250|UniProtKB:P55075}.
CC   -!- SUBUNIT: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and
CC       FGFR4. Affinity between fibroblast growth factors (FGFs) and their
CC       receptors is increased by heparan sulfate glycosaminoglycans that
CC       function as coreceptors (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC       {ECO:0000305}.
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DR   EMBL; AF022487; AAC17218.1; -; mRNA.
DR   AlphaFoldDB; O62682; -.
DR   SMR; O62682; -.
DR   STRING; 9615.ENSCAFP00000014598; -.
DR   PaxDb; O62682; -.
DR   eggNOG; KOG3885; Eukaryota.
DR   InParanoid; O62682; -.
DR   Proteomes; UP000002254; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR   GO; GO:0005105; F:type 1 fibroblast growth factor receptor binding; IBA:GO_Central.
DR   GO; GO:0005111; F:type 2 fibroblast growth factor receptor binding; IBA:GO_Central.
DR   GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IBA:GO_Central.
DR   GO; GO:0035050; P:embryonic heart tube development; IBA:GO_Central.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0003007; P:heart morphogenesis; IBA:GO_Central.
DR   GO; GO:0035108; P:limb morphogenesis; IBA:GO_Central.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0003148; P:outflow tract septum morphogenesis; ISS:UniProtKB.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR   GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR   InterPro; IPR028249; FGF8.
DR   InterPro; IPR002209; Fibroblast_GF_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR11486; PTHR11486; 1.
DR   PANTHER; PTHR11486:SF3; PTHR11486:SF3; 1.
DR   Pfam; PF00167; FGF; 1.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Glycoprotein; Growth factor;
KW   Mitogen; Reference proteome; Secreted.
FT   CHAIN           <1..>82
FT                   /note="Fibroblast growth factor 8"
FT                   /id="PRO_0000147601"
FT   CARBOHYD        68
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT                   /evidence="ECO:0000312|EMBL:AAC17218.1"
FT   NON_TER         82
FT                   /evidence="ECO:0000312|EMBL:AAC17218.1"
SQ   SEQUENCE   82 AA;  9227 MW;  A22CDCAF2A7B27A8 CRC64;
     NKRINAMAED GDPFAKLIVE TDTFGSRVRV RGAETGLYIC MNKKGKLIAK SNGKGKDCVF
     TEIELENNYT ALQNAKYEGW YM