ID   FGF9_DIDAL              Reviewed;         209 AA.
AC   Q3ZFI5;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Fibroblast growth factor 9;
DE            Short=FGF-9;
DE   AltName: Full=Glia-activating factor;
DE            Short=GAF;
DE   AltName: Full=Heparin-binding growth factor 9;
DE            Short=HBGF-9;
DE   Flags: Precursor;
GN   Name=FGF9;
OS   Didelphis albiventris (White-eared opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Didelphimorphia; Didelphidae; Didelphis.
OX   NCBI_TaxID=42716;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16188224; DOI=10.1016/j.archoralbio.2005.08.003;
RA   Torres C.B.B., Goes V.S., Goes A.M., Pacifico L.G.G., Silva G.A.,
RA   Junior N.L., Alves J.B.;
RT   "Fibroblast growth factor 9: cloning and immunolocalisation during tooth
RT   development in Didelphis albiventris.";
RL   Arch. Oral Biol. 51:263-272(2006).
CC   -!- FUNCTION: Plays an important role in the regulation of embryonic
CC       development, cell proliferation, cell differentiation and cell
CC       migration. May have a role in glial cell growth and differentiation
CC       during development, gliosis during repair and regeneration of brain
CC       tissue after damage, differentiation and survival of neuronal cells,
CC       and growth stimulation of glial tumors (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and
CC       FGFR4. Affinity between fibroblast growth factors (FGFs) and their
CC       receptors is increased by heparan sulfate glycosaminoglycans that
CC       function as coreceptors (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC       {ECO:0000305}.
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DR   EMBL; AY864823; AAX58114.1; -; mRNA.
DR   AlphaFoldDB; Q3ZFI5; -.
DR   SMR; Q3ZFI5; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005104; F:fibroblast growth factor receptor binding; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR   CDD; cd00058; FGF; 1.
DR   InterPro; IPR028251; FGF9.
DR   InterPro; IPR002209; Fibroblast_GF_fam.
DR   InterPro; IPR008996; IL1/FGF.
DR   PANTHER; PTHR11486; PTHR11486; 1.
DR   PANTHER; PTHR11486:SF28; PTHR11486:SF28; 1.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00263; HBGFFGF.
DR   SMART; SM00442; FGF; 1.
DR   SUPFAM; SSF50353; SSF50353; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Glycoprotein; Growth factor;
KW   Heparin-binding; Mitogen; Secreted.
FT   PROPEP          1..3
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000270514"
FT   CHAIN           4..209
FT                   /note="Fibroblast growth factor 9"
FT                   /id="PRO_0000270515"
FT   CARBOHYD        80
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   209 AA;  23542 MW;  F41A03A9C9D219BB CRC64;
     MAPLGEVGNY FGVQDAAVPF GNVPVLPVDS PVLLSDHLGQ SEAGGLPRGP AVTDLDHLKG
     ILRRRQLYCR TGFHLEIFPN GTIQGTRQDH SRFGILEFIS IAVGLVSIRG VDSGLYLGMN
     EKGELYGSEK LTQECVFREQ FEENWYNTYS SNLYKHVDTG RRYYVALNKD GTPREGTRTK
     RHQKFTHFLP RPVDLEKVPE LYKDILSQS