FGF9_PIG
ID FGF9_PIG Reviewed; 208 AA.
AC Q95L12;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Fibroblast growth factor 9;
DE Short=FGF-9;
DE AltName: Full=Glia-activating factor;
DE Short=GAF;
DE AltName: Full=HBGF-9;
DE Flags: Precursor;
GN Name=FGF9;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Paradis V., Silversides D.W.;
RT "Sus scrofa fgf9 cDNA.";
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an important role in the regulation of embryonic
CC development, cell proliferation, cell differentiation and cell
CC migration. May have a role in glial cell growth and differentiation
CC during development, gliosis during repair and regeneration of brain
CC tissue after damage, differentiation and survival of neuronal cells,
CC and growth stimulation of glial tumors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and
CC FGFR4. Affinity between fibroblast growth factors (FGFs) and their
CC receptors is increased by heparan sulfate glycosaminoglycans that
CC function as coreceptors (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; AY033825; AAK61609.2; -; mRNA.
DR RefSeq; NP_998966.1; NM_213801.1.
DR AlphaFoldDB; Q95L12; -.
DR SMR; Q95L12; -.
DR STRING; 9823.ENSSSCP00000009895; -.
DR PaxDb; Q95L12; -.
DR Ensembl; ENSSSCT00000010161; ENSSSCP00000009895; ENSSSCG00000009278.
DR Ensembl; ENSSSCT00005053206; ENSSSCP00005032857; ENSSSCG00005033292.
DR Ensembl; ENSSSCT00015049115; ENSSSCP00015019561; ENSSSCG00015036929.
DR Ensembl; ENSSSCT00025057795; ENSSSCP00025024464; ENSSSCG00025042612.
DR Ensembl; ENSSSCT00030052394; ENSSSCP00030023905; ENSSSCG00030037641.
DR Ensembl; ENSSSCT00035034903; ENSSSCP00035013833; ENSSSCG00035026458.
DR Ensembl; ENSSSCT00045017075; ENSSSCP00045011772; ENSSSCG00045010081.
DR Ensembl; ENSSSCT00050103833; ENSSSCP00050045467; ENSSSCG00050075682.
DR Ensembl; ENSSSCT00055033736; ENSSSCP00055026818; ENSSSCG00055017122.
DR Ensembl; ENSSSCT00060103177; ENSSSCP00060045013; ENSSSCG00060075367.
DR Ensembl; ENSSSCT00065048187; ENSSSCP00065020788; ENSSSCG00065035373.
DR Ensembl; ENSSSCT00070026166; ENSSSCP00070021718; ENSSSCG00070013418.
DR GeneID; 396717; -.
DR KEGG; ssc:396717; -.
DR CTD; 2254; -.
DR VGNC; VGNC:103943; FGF9.
DR eggNOG; KOG3885; Eukaryota.
DR GeneTree; ENSGT00940000160956; -.
DR HOGENOM; CLU_081609_0_0_1; -.
DR InParanoid; Q95L12; -.
DR OMA; FFWIYLS; -.
DR OrthoDB; 1097566at2759; -.
DR TreeFam; TF317805; -.
DR Reactome; R-SSC-109704; PI3K Cascade.
DR Reactome; R-SSC-1257604; PIP3 activates AKT signaling.
DR Reactome; R-SSC-190322; FGFR4 ligand binding and activation.
DR Reactome; R-SSC-190373; FGFR1c ligand binding and activation.
DR Reactome; R-SSC-5654219; Phospholipase C-mediated cascade: FGFR1.
DR Reactome; R-SSC-5654228; Phospholipase C-mediated cascade, FGFR4.
DR Reactome; R-SSC-5654687; Downstream signaling of activated FGFR1.
DR Reactome; R-SSC-5654688; SHC-mediated cascade:FGFR1.
DR Reactome; R-SSC-5654689; PI-3K cascade:FGFR1.
DR Reactome; R-SSC-5654693; FRS-mediated FGFR1 signaling.
DR Reactome; R-SSC-5654712; FRS-mediated FGFR4 signaling.
DR Reactome; R-SSC-5654719; SHC-mediated cascade:FGFR4.
DR Reactome; R-SSC-5654720; PI-3K cascade:FGFR4.
DR Reactome; R-SSC-5654726; Negative regulation of FGFR1 signaling.
DR Reactome; R-SSC-5654733; Negative regulation of FGFR4 signaling.
DR Reactome; R-SSC-5673001; RAF/MAP kinase cascade.
DR Reactome; R-SSC-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR Proteomes; UP000008227; Chromosome 11.
DR Proteomes; UP000314985; Chromosome 11.
DR Bgee; ENSSSCG00000009278; Expressed in oocyte and 33 other tissues.
DR ExpressionAtlas; Q95L12; baseline and differential.
DR Genevisible; Q95L12; SS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0032924; P:activin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0060038; P:cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0002062; P:chondrocyte differentiation; IEA:Ensembl.
DR GO; GO:0048566; P:embryonic digestive tract development; IEA:Ensembl.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
DR GO; GO:0048706; P:embryonic skeletal system development; IEA:Ensembl.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR GO; GO:0030324; P:lung development; IBA:GO_Central.
DR GO; GO:0060484; P:lung-associated mesenchyme development; IEA:Ensembl.
DR GO; GO:0030238; P:male sex determination; IEA:Ensembl.
DR GO; GO:0010463; P:mesenchymal cell proliferation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0032927; P:positive regulation of activin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; IBA:GO_Central.
DR GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Ensembl.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IBA:GO_Central.
DR GO; GO:2000243; P:positive regulation of reproductive process; IEA:Ensembl.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:1904707; P:positive regulation of vascular associated smooth muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0006606; P:protein import into nucleus; IEA:Ensembl.
DR GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
DR GO; GO:0048505; P:regulation of timing of cell differentiation; IEA:Ensembl.
DR GO; GO:0060011; P:Sertoli cell proliferation; IEA:Ensembl.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:Ensembl.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028251; FGF9.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF28; PTHR11486:SF28; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Glycoprotein; Growth factor;
KW Heparin-binding; Mitogen; Reference proteome; Secreted.
FT PROPEP 1..3
FT /evidence="ECO:0000250"
FT /id="PRO_0000270516"
FT CHAIN 4..208
FT /note="Fibroblast growth factor 9"
FT /id="PRO_0000270517"
FT CARBOHYD 79
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 208 AA; 23455 MW; 05FD0E2048CCC5E5 CRC64;
MAPLGEVGNY FGVQDAVPFG NVPVLPVDSP VLLSDHLSQS EAGGLPRGPA VTDLDHLKGI
LRRRQLYCRT GFHLEIFPNG TIQGTRKDHS RFGILEFISI AVGLVSIRGV DSGLYLGMNE
KGELYGSEKL TQECVFREQF EENWYNTYSS NLYKHVDTGR RFYVALNKDG TPREGTRTKR
HQKFTHFLPR PVDPDKVPEL YKDILSQS
