FGF9_XENLA
ID FGF9_XENLA Reviewed; 209 AA.
AC Q91875;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Fibroblast growth factor 9;
DE Short=FGF-9;
DE AltName: Full=Glia-activating factor;
DE Short=GAF;
DE AltName: Full=HBGF-9;
DE AltName: Full=Heparin-binding growth factor 9;
DE AltName: Full=XFGF-9;
DE Flags: Precursor;
GN Name=fgf9; Synonyms=fgf-9;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8853991;
RX DOI=10.1002/(sici)1097-0177(199608)206:4<427::aid-aja8>3.0.co;2-k;
RA Song J., Slack J.M.W.;
RT "XFGF-9: a new fibroblast growth factor from Xenopus embryos.";
RL Dev. Dyn. 206:427-436(1996).
CC -!- FUNCTION: May have a role in muscle development and neural
CC differentiation, has no specific role in anteroposterior patterning.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Maternal transcript is found mainly in the animal
CC hemisphere. Zygotic transcript is found around the blastopore and in
CC the late gastrula stage, in the dorsal part. In later stages it is
CC found along the dorsal part and head region.
CC -!- DEVELOPMENTAL STAGE: The maternal protein is detected up to the
CC blastula stage but declines by the early glastrula. Zygotic expression
CC starts at around early gastrula; the level of expression reached at
CC stage 15 persists during neurula and tailbud stages, and is further
CC increased during the tadpole stages.
CC -!- PTM: Glycosylated.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000305}.
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DR EMBL; U47622; AAC59936.1; -; mRNA.
DR RefSeq; NP_001079276.1; NM_001085807.1.
DR AlphaFoldDB; Q91875; -.
DR SMR; Q91875; -.
DR GeneID; 378562; -.
DR KEGG; xla:378562; -.
DR CTD; 378562; -.
DR Xenbase; XB-GENE-6067935; fgf9.S.
DR OrthoDB; 1097566at2759; -.
DR Proteomes; UP000186698; Chromosome 2S.
DR Bgee; 378562; Expressed in muscle tissue and 6 other tissues.
DR GO; GO:0070062; C:extracellular exosome; ISA:AgBase.
DR GO; GO:0005615; C:extracellular space; ISA:AgBase.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0001525; P:angiogenesis; ISA:AgBase.
DR GO; GO:0007267; P:cell-cell signaling; ISA:AgBase.
DR GO; GO:0002062; P:chondrocyte differentiation; ISA:AgBase.
DR GO; GO:0048566; P:embryonic digestive tract development; ISA:AgBase.
DR GO; GO:0030326; P:embryonic limb morphogenesis; ISA:AgBase.
DR GO; GO:0048706; P:embryonic skeletal system development; ISA:AgBase.
DR GO; GO:0001654; P:eye development; ISA:AgBase.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; ISA:AgBase.
DR GO; GO:0042472; P:inner ear morphogenesis; ISA:AgBase.
DR GO; GO:0030324; P:lung development; ISA:AgBase.
DR GO; GO:0060484; P:lung-associated mesenchyme development; ISA:AgBase.
DR GO; GO:0008584; P:male gonad development; ISA:AgBase.
DR GO; GO:0030238; P:male sex determination; ISA:AgBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISA:AgBase.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; ISA:AgBase.
DR GO; GO:0001649; P:osteoblast differentiation; ISA:AgBase.
DR GO; GO:0032927; P:positive regulation of activin receptor signaling pathway; ISA:AgBase.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; ISA:AgBase.
DR GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; ISA:AgBase.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISA:AgBase.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; ISA:AgBase.
DR GO; GO:0010628; P:positive regulation of gene expression; ISA:AgBase.
DR GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; ISA:AgBase.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; ISA:AgBase.
DR GO; GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; ISA:AgBase.
DR GO; GO:0006606; P:protein import into nucleus; ISA:AgBase.
DR GO; GO:0048505; P:regulation of timing of cell differentiation; ISA:AgBase.
DR GO; GO:0021762; P:substantia nigra development; ISA:AgBase.
DR CDD; cd00058; FGF; 1.
DR InterPro; IPR028251; FGF9.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; PTHR11486; 1.
DR PANTHER; PTHR11486:SF28; PTHR11486:SF28; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; SSF50353; 1.
DR PROSITE; PS00247; HBGF_FGF; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Glycoprotein; Growth factor;
KW Heparin-binding; Mitogen; Reference proteome; Secreted.
FT PROPEP 1..3
FT /evidence="ECO:0000250"
FT /id="PRO_0000008979"
FT CHAIN 4..209
FT /note="Fibroblast growth factor 9"
FT /id="PRO_0000008980"
FT CARBOHYD 80
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000305"
SQ SEQUENCE 209 AA; 23663 MW; 26CBB229797FCFBF CRC64;
MAPLGEVGNY FGVQDAVSFG NVPVLQVDTP VLLSDHMSHH SEAGGLPRGS AVTDLEHLKG
ILRRRQLYCR TGFHLEIFPN GTIQGTRQDH NRFGILEFIS IAVGLVSIRG VDSGLYLGMN
EKGELYGSEK LTQECVFREQ FEENWYNTYS SNIYKHADTG RRYYVALNKD GTSRDGTRTK
RHQKFTHFLP RPVDPEKVPE LYKDILSQS
