FGFP2_HUMAN
ID FGFP2_HUMAN Reviewed; 223 AA.
AC Q9BYJ0;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Fibroblast growth factor-binding protein 2;
DE Short=FGF-BP2;
DE Short=FGF-binding protein 2;
DE Short=FGFBP-2;
DE AltName: Full=37 kDa killer-specific secretory protein;
DE Short=Ksp37;
DE AltName: Full=HBp17-related protein;
DE Short=HBp17-RP;
DE Flags: Precursor;
GN Name=FGFBP2; Synonyms=KSP37; ORFNames=UNQ425/PRO1065;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RC TISSUE=Cytotoxic T-cell;
RX PubMed=11342666; DOI=10.4049/jimmunol.166.10.6404;
RA Ogawa K., Tanaka K., Ishii A., Nakamura Y., Kondo S., Sugamura K.,
RA Takano S., Nakamura M., Nagata K.;
RT "A novel serum protein that is selectively produced by cytotoxic
RT lymphocytes.";
RL J. Immunol. 166:6404-6412(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Epidermal carcinoma;
RA Sato J.D., Chapline M.C.;
RT "cDNA encoding a human protein related to FGF-binding protein HBp17 (HBp17-
RT RP).";
RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q9BYJ0; P55061: TMBIM6; NbExp=3; IntAct=EBI-12911356, EBI-1045825;
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC {ECO:0000269|PubMed:11342666}.
CC -!- TISSUE SPECIFICITY: Expressed in serum, peripheral leukocytes and
CC cytotoxic T-lymphocytes, but not in granulocytes and monocytes (at
CC protein level). {ECO:0000269|PubMed:11342666}.
CC -!- SIMILARITY: Belongs to the fibroblast growth factor-binding protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB021123; BAB39770.1; -; mRNA.
DR EMBL; AF361936; AAK51503.1; -; mRNA.
DR EMBL; AY358978; AAQ89337.1; -; mRNA.
DR EMBL; BC025720; AAH25720.1; -; mRNA.
DR CCDS; CCDS3419.1; -.
DR RefSeq; NP_114156.1; NM_031950.3.
DR AlphaFoldDB; Q9BYJ0; -.
DR BioGRID; 123799; 5.
DR IntAct; Q9BYJ0; 2.
DR STRING; 9606.ENSP00000259989; -.
DR GlyGen; Q9BYJ0; 2 sites, 2 O-linked glycans (2 sites).
DR iPTMnet; Q9BYJ0; -.
DR PhosphoSitePlus; Q9BYJ0; -.
DR BioMuta; FGFBP2; -.
DR DMDM; 74733476; -.
DR jPOST; Q9BYJ0; -.
DR MassIVE; Q9BYJ0; -.
DR PaxDb; Q9BYJ0; -.
DR PeptideAtlas; Q9BYJ0; -.
DR PRIDE; Q9BYJ0; -.
DR ProteomicsDB; 79654; -.
DR Antibodypedia; 43624; 118 antibodies from 24 providers.
DR DNASU; 83888; -.
DR Ensembl; ENST00000259989.7; ENSP00000259989.6; ENSG00000137441.8.
DR GeneID; 83888; -.
DR KEGG; hsa:83888; -.
DR MANE-Select; ENST00000259989.7; ENSP00000259989.6; NM_031950.4; NP_114156.1.
DR UCSC; uc003gon.4; human.
DR CTD; 83888; -.
DR DisGeNET; 83888; -.
DR GeneCards; FGFBP2; -.
DR HGNC; HGNC:29451; FGFBP2.
DR HPA; ENSG00000137441; Tissue enhanced (bone).
DR MIM; 607713; gene.
DR neXtProt; NX_Q9BYJ0; -.
DR OpenTargets; ENSG00000137441; -.
DR PharmGKB; PA162388435; -.
DR VEuPathDB; HostDB:ENSG00000137441; -.
DR eggNOG; ENOG502S0EZ; Eukaryota.
DR GeneTree; ENSGT00940000154372; -.
DR HOGENOM; CLU_086542_0_0_1; -.
DR InParanoid; Q9BYJ0; -.
DR OMA; CEYRGQP; -.
DR OrthoDB; 1528446at2759; -.
DR PhylomeDB; Q9BYJ0; -.
DR TreeFam; TF335877; -.
DR PathwayCommons; Q9BYJ0; -.
DR Reactome; R-HSA-190377; FGFR2b ligand binding and activation.
DR SignaLink; Q9BYJ0; -.
DR BioGRID-ORCS; 83888; 14 hits in 1064 CRISPR screens.
DR GenomeRNAi; 83888; -.
DR Pharos; Q9BYJ0; Tbio.
DR PRO; PR:Q9BYJ0; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q9BYJ0; protein.
DR Bgee; ENSG00000137441; Expressed in tibia and 114 other tissues.
DR Genevisible; Q9BYJ0; HS.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR GO; GO:0019838; F:growth factor binding; IBA:GO_Central.
DR GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR InterPro; IPR010510; FGF1-bd.
DR PANTHER; PTHR15258; PTHR15258; 1.
DR Pfam; PF06473; FGF-BP1; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Growth factor binding; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..223
FT /note="Fibroblast growth factor-binding protein 2"
FT /id="PRO_0000245860"
FT REGION 23..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 43..63
FT /evidence="ECO:0000250"
FT DISULFID 72..106
FT /evidence="ECO:0000250"
FT DISULFID 81..117
FT /evidence="ECO:0000250"
FT DISULFID 206..214
FT /evidence="ECO:0000250"
FT VARIANT 28
FT /note="S -> N (in dbSNP:rs35496730)"
FT /id="VAR_061171"
FT VARIANT 84
FT /note="F -> L (in dbSNP:rs2286459)"
FT /id="VAR_059287"
FT VARIANT 90
FT /note="P -> S (in dbSNP:rs758329)"
FT /id="VAR_049065"
SQ SEQUENCE 223 AA; 24581 MW; 792E68933E7929D9 CRC64;
MKFVPCLLLV TLSCLGTLGQ APRQKQGSTG EEFHFQTGGR DSCTMRPSSL GQGAGEVWLR
VDCRNTDQTY WCEYRGQPSM CQAFAADPKP YWNQALQELR RLHHACQGAP VLRPSVCREA
GPQAHMQQVT SSLKGSPEPN QQPEAGTPSL RPKATVKLTE ATQLGKDSME ELGKAKPTTR
PTAKPTQPGP RPGGNEEAKK KAWEHCWKPF QALCAFLISF FRG
