FGFP3_HUMAN
ID FGFP3_HUMAN Reviewed; 258 AA.
AC Q8TAT2; B2RD68; Q8NBN0;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Fibroblast growth factor-binding protein 3;
DE Short=FGF-BP3;
DE Short=FGF-binding protein 3;
DE Short=FGFBP-3;
DE Flags: Precursor;
GN Name=FGFBP3; Synonyms=C10orf13; ORFNames=PSEC0101;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Swift M.R., Tassi E., Wellstein A.;
RT "Identification and characterization of a novel member of the fibroblast
RT growth factor-binding protein family, FGF-BP3.";
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-206.
RC TISSUE=Teratocarcinoma;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP FUNCTION, INTERACTION WITH FGF2, SUBCELLULAR LOCATION, AND IDENTIFICATION
RP BY MASS SPECTROMETRY.
RX PubMed=18669637; DOI=10.1074/jbc.m802144200;
RA Zhang W., Chen Y., Swift M.R., Tassi E., Stylianou D.C., Gibby K.A.,
RA Riegel A.T., Wellstein A.;
RT "Effect of FGF-binding protein 3 on vascular permeability.";
RL J. Biol. Chem. 283:28329-28337(2008).
CC -!- FUNCTION: Heparin-binding protein which binds to FGF2, prevents binding
CC of FGF2 to heparin and probably inhibits immobilization of FGF2 on
CC extracellular matrix glycosaminoglycans, allowing its release and
CC subsequent activation of FGFR signaling which leads to increased
CC vascular permeability. {ECO:0000269|PubMed:18669637}.
CC -!- SUBUNIT: Interacts with FGF2. {ECO:0000269|PubMed:18669637}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18669637}.
CC -!- SIMILARITY: Belongs to the fibroblast growth factor-binding protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQ503576; ABF56582.1; -; mRNA.
DR EMBL; AK075410; BAC11602.1; -; mRNA.
DR EMBL; AK315427; BAG37815.1; -; mRNA.
DR EMBL; AL359198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471066; EAW50104.1; -; Genomic_DNA.
DR EMBL; BC025966; AAH25966.1; -; mRNA.
DR CCDS; CCDS7418.1; -.
DR RefSeq; NP_689642.3; NM_152429.4.
DR AlphaFoldDB; Q8TAT2; -.
DR SMR; Q8TAT2; -.
DR STRING; 9606.ENSP00000339067; -.
DR iPTMnet; Q8TAT2; -.
DR PhosphoSitePlus; Q8TAT2; -.
DR BioMuta; FGFBP3; -.
DR DMDM; 74751362; -.
DR EPD; Q8TAT2; -.
DR jPOST; Q8TAT2; -.
DR MassIVE; Q8TAT2; -.
DR PaxDb; Q8TAT2; -.
DR PeptideAtlas; Q8TAT2; -.
DR PRIDE; Q8TAT2; -.
DR ProteomicsDB; 73915; -.
DR Antibodypedia; 52908; 85 antibodies from 22 providers.
DR DNASU; 143282; -.
DR Ensembl; ENST00000311575.6; ENSP00000339067.3; ENSG00000174721.10.
DR GeneID; 143282; -.
DR KEGG; hsa:143282; -.
DR MANE-Select; ENST00000311575.6; ENSP00000339067.3; NM_152429.5; NP_689642.3.
DR UCSC; uc001khq.5; human.
DR CTD; 143282; -.
DR DisGeNET; 143282; -.
DR GeneCards; FGFBP3; -.
DR HGNC; HGNC:23428; FGFBP3.
DR HPA; ENSG00000174721; Low tissue specificity.
DR neXtProt; NX_Q8TAT2; -.
DR OpenTargets; ENSG00000174721; -.
DR PharmGKB; PA162388444; -.
DR VEuPathDB; HostDB:ENSG00000174721; -.
DR eggNOG; ENOG502S2Z7; Eukaryota.
DR GeneTree; ENSGT00940000154372; -.
DR HOGENOM; CLU_1111111_0_0_1; -.
DR InParanoid; Q8TAT2; -.
DR OMA; CAYRGEP; -.
DR OrthoDB; 1532497at2759; -.
DR PhylomeDB; Q8TAT2; -.
DR TreeFam; TF335877; -.
DR PathwayCommons; Q8TAT2; -.
DR Reactome; R-HSA-190377; FGFR2b ligand binding and activation.
DR BioGRID-ORCS; 143282; 12 hits in 1071 CRISPR screens.
DR GenomeRNAi; 143282; -.
DR Pharos; Q8TAT2; Tbio.
DR PRO; PR:Q8TAT2; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q8TAT2; protein.
DR Bgee; ENSG00000174721; Expressed in ventricular zone and 103 other tissues.
DR Genevisible; Q8TAT2; HS.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:UniProtKB.
DR GO; GO:0005576; C:extracellular region; IDA:MGI.
DR GO; GO:0017134; F:fibroblast growth factor binding; IPI:MGI.
DR GO; GO:0019838; F:growth factor binding; IBA:GO_Central.
DR GO; GO:0008201; F:heparin binding; IDA:MGI.
DR GO; GO:0007267; P:cell-cell signaling; IBA:GO_Central.
DR GO; GO:0045743; P:positive regulation of fibroblast growth factor receptor signaling pathway; IGI:MGI.
DR GO; GO:0043117; P:positive regulation of vascular permeability; IDA:MGI.
DR InterPro; IPR010510; FGF1-bd.
DR PANTHER; PTHR15258; PTHR15258; 1.
DR Pfam; PF06473; FGF-BP1; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Growth factor binding; Heparin-binding; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..258
FT /note="Fibroblast growth factor-binding protein 3"
FT /id="PRO_0000244264"
FT REGION 146..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 59..80
FT /evidence="ECO:0000250"
FT DISULFID 90..124
FT /evidence="ECO:0000250"
FT DISULFID 241..249
FT /evidence="ECO:0000250"
FT VARIANT 107
FT /note="A -> T (in dbSNP:rs10881994)"
FT /id="VAR_059288"
FT VARIANT 206
FT /note="E -> V (in dbSNP:rs1107947)"
FT /evidence="ECO:0000269|PubMed:16303743"
FT /id="VAR_026888"
SQ SEQUENCE 258 AA; 27590 MW; C6290744F0AB9DEF CRC64;
MTPPKLRASL SPSLLLLLSG CLLAAARREK GAASNVAEPV PGPTGGSSGR FLSPEQHACS
WQLLLPAPEA AAGSELALRC QSPDGARHQC AYRGHPERCA AYAARRAHFW KQVLGGLRKK
RRPCHDPAPL QARLCAGKKG HGAELRLVPR ASPPARPTVA GFAGESKPRA RNRGRTRERA
SGPAAGTPPP QSAPPKENPS ERKTNEGKRK AALVPNEERP MGTGPDPDGL DGNAELTETY
CAEKWHSLCN FFVNFWNG
