FGL1L_CHICK
ID FGL1L_CHICK Reviewed; 281 AA.
AC O93526; F1P1D2;
DT 22-JUL-2015, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2015, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Fibrinogen-like protein 1-like protein {ECO:0000305};
DE AltName: Full=Cytidine deaminase {ECO:0000303|PubMed:9792440};
DE Short=CDD {ECO:0000312|EMBL:AAC64000.1};
DE Flags: Precursor;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY,
RP BIOPHYSICOCHEMICAL PROPERTIES, AND MUTAGENESIS OF HIS-140 AND GLU-143.
RC TISSUE=Small intestine;
RX PubMed=9792440; DOI=10.1515/bchm.1998.379.8-9.1075;
RA Anant S., Yu H., Davidson N.O.;
RT "Evolutionary origins of the mammalian apolipoproteinB RNA editing enzyme,
RT apobec-1: structural homology inferred from analysis of a cloned chicken
RT small intestinal cytidine deaminase.";
RL Biol. Chem. 379:1075-1081(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Red jungle fowl;
RX PubMed=15592404; DOI=10.1038/nature03154;
RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA Wilson R.K.;
RT "Sequence and comparative analysis of the chicken genome provide unique
RT perspectives on vertebrate evolution.";
RL Nature 432:695-716(2004).
CC -!- FUNCTION: Shows a cytidine deaminase activity on 2'-deoxycytidine (in
CC vitro), however shows no RNA editing activity (in vitro).
CC {ECO:0000269|PubMed:9792440}.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC Kinetic parameters:
CC KM=0.22 uM for 2'-deoxycytidine {ECO:0000269|PubMed:9792440};
CC -!- TISSUE SPECIFICITY: Expressed in smal intestine, colon and lung.
CC {ECO:0000269|PubMed:9792440}.
CC -!- CAUTION: Although in PubMed:9792440 a cytidine deaminase activity has
CC been shown in vitro, it would be the first time that a member of this
CC family that contains a fibrinogen C-terminal domain signature shows an
CC enzymatic activity. And it is surprising that this protein that shows
CC an in vitro cytidine deaminase activity does not have the cytidine and
CC deoxycytidylate deaminases domain signature.
CC {ECO:0000305|PubMed:9792440}.
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DR EMBL; AF059262; AAC64000.1; -; mRNA.
DR EMBL; AADN03012049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; O93526; -.
DR SMR; O93526; -.
DR STRING; 9031.ENSGALP00000022348; -.
DR PaxDb; O93526; -.
DR VEuPathDB; HostDB:geneid_395773; -.
DR eggNOG; KOG2579; Eukaryota.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004126; F:cytidine deaminase activity; IDA:UniProtKB.
DR GO; GO:0047844; F:deoxycytidine deaminase activity; IDA:UniProtKB.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 3.90.215.10; -; 1.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR SMART; SM00186; FBG; 1.
DR SUPFAM; SSF56496; SSF56496; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Reference proteome; Signal.
FT SIGNAL 1..33
FT /evidence="ECO:0000255"
FT CHAIN 34..281
FT /note="Fibrinogen-like protein 1-like protein"
FT /evidence="ECO:0000255"
FT /id="PRO_0000433469"
FT DOMAIN 34..246
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT REGION 260..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 43..69
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT DISULFID 201..213
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00739"
FT MUTAGEN 140
FT /note="H->R: Abolishes cytidine deaminase activity."
FT /evidence="ECO:0000269|PubMed:9792440"
FT MUTAGEN 143
FT /note="E->Q: Abolishes cytidine deaminase activity."
FT /evidence="ECO:0000269|PubMed:9792440"
FT CONFLICT 105
FT /note="N -> D (in Ref. 1; AAC64000)"
FT /evidence="ECO:0000305"
FT CONFLICT 253
FT /note="G -> R (in Ref. 1; AAC64000)"
FT /evidence="ECO:0000305"
FT CONFLICT 271
FT /note="T -> I (in Ref. 1; AAC64000)"
FT /evidence="ECO:0000305"
FT CONFLICT 281
FT /note="Missing (in Ref. 1; AAC64000)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 281 AA; 31298 MW; 942D8BA9035F0C71 CRC64;
MGLQAGTRQL HGNLILLPVA VVMLLLCTSP VCATASVGLP ADCSRLTSSS PSGVYVIQPA
QSPPRVVWCD MDTEGKGWTV VQRNTYSTEI TWKESWTTYK YGFGNVQGDH WLGTEYLHLL
TQQGTYKVRF VVRDKANVTH YAEYDIFRVE SESSGYPLRL GRLLSSGKDY LTSYYSSYGG
IHDNMKFSTV DKDQDQHSGN CASSYGGWWY DRCQNVLLNG KKYILWPEIC PRVTACRPSS
WSNPPMCADC ARGWGSATIP SRSPSLPSPI TATHTVRNQL Q
