FGNE_ASPFU
ID FGNE_ASPFU Reviewed; 434 AA.
AC Q4WKX3;
DT 17-JUN-2020, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=MFS-type transporter AFUA_1G00970 {ECO:0000303|PubMed:32083553};
DE AltName: Full=Fumigermin biosynthesis cluster protein AFUA_1G00970 {ECO:0000303|PubMed:32083553};
GN ORFNames=AFUA_1G00970;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
RN [2]
RP FUNCTION, AND INDUCTION.
RX PubMed=32083553; DOI=10.7554/elife.52541;
RA Stroe M.C., Netzker T., Scherlach K., Krueger T., Hertweck C., Valiante V.,
RA Brakhage A.A.;
RT "Targeted induction of a silent fungal gene cluster encoding the bacteria-
RT specific germination inhibitor fumigermin.";
RL Elife 9:0-0(2020).
CC -!- FUNCTION: MFS-type transporter; part of the gene cluster that mediates
CC the biosynthesis of fumigermin that inhibits germination of spores of
CC the inducing S.rapamycinicus, and thus helps the fungus to defend
CC resources in the shared habitat against a bacterial competitor
CC (PubMed:32083553). May be involved in the secretion of fumigermin
CC (Probable). {ECO:0000269|PubMed:32083553, ECO:0000305|PubMed:32083553}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:32083553};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- INDUCTION: Expression is up-regulated during co-cultivation of
CC A.fumigatus with Streptomyces rapamycinicus that triggersthe production
CC of the polyketide fumigermin during the bacterial-fungal interaction.
CC {ECO:0000269|PubMed:32083553}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC Monocarboxylate porter (TC 2.A.1.13) family. {ECO:0000305}.
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DR EMBL; AAHF01000007; EAL87809.1; -; Genomic_DNA.
DR RefSeq; XP_749847.1; XM_744754.1.
DR AlphaFoldDB; Q4WKX3; -.
DR SMR; Q4WKX3; -.
DR EnsemblFungi; EAL87809; EAL87809; AFUA_1G00970.
DR GeneID; 3507515; -.
DR KEGG; afm:AFUA_1G00970; -.
DR VEuPathDB; FungiDB:Afu1g00970; -.
DR HOGENOM; CLU_001265_1_1_1; -.
DR InParanoid; Q4WKX3; -.
DR OMA; FYHATIL; -.
DR OrthoDB; 916876at2759; -.
DR Proteomes; UP000002530; Chromosome 1.
DR GO; GO:0071627; C:integral component of fungal-type vacuolar membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..434
FT /note="MFS-type transporter AFUA_1G00970"
FT /id="PRO_0000449930"
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..347
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 393..413
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 201..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 434 AA; 45948 MW; 2B2E119664F27764 CRC64;
MTVAISNPAA PPVSARAYLS VIGGTCALLC TVGFVVAFGV FQGYYTEHLL RGMSEFDIPW
IGSASIFLLY VSAPICGVLV DRFGPKVLLI AGSIGVLVAI FMISLCSQYY QIFLAQAVLL
GISMGFVTWP PFAVVSRNLP HHRGLALGVI TGGSSVGGIV WSIMIEELLT KRNLGFPWTV
RVLGFTMLPL LAFACISITE PPKQSQPQPR PALEATVEGG SASPTPKPEY ASLPLLRSTV
FISICVGFGL AFLGLFNPFF YISSYAAGHG ASAQTSSYMI SIMNAATLFG RVIPGIVADR
VGHYNVMIFV LLASGITSFC WTEVRSLTGL VIWSIAYGFS SGAILSLQGA CAGKIATPQN
QGKAIGFLQG SLAVTVLVGS PIGGQLLGHY GYLSLSMFTG ATLVMGAVVM GYARLCLNRS
PMEAHQFRFL LAPN
