FGOP2_DROME
ID FGOP2_DROME Reviewed; 315 AA.
AC Q9VM65;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=FGFR1 oncogene partner 2 homolog {ECO:0000305};
GN Name=Fgop2 {ECO:0000312|FlyBase:FBgn0031871};
GN ORFNames=CG10158 {ECO:0000312|FlyBase:FBgn0031871};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the SIKE family. {ECO:0000305}.
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DR EMBL; AE014134; AAF52460.1; -; Genomic_DNA.
DR EMBL; BT005202; AAO61759.1; -; mRNA.
DR RefSeq; NP_001260171.1; NM_001273242.1.
DR RefSeq; NP_609084.1; NM_135240.4.
DR AlphaFoldDB; Q9VM65; -.
DR SMR; Q9VM65; -.
DR BioGRID; 60121; 23.
DR IntAct; Q9VM65; 1.
DR STRING; 7227.FBpp0304603; -.
DR PaxDb; Q9VM65; -.
DR PRIDE; Q9VM65; -.
DR EnsemblMetazoa; FBtr0079366; FBpp0078994; FBgn0031871.
DR EnsemblMetazoa; FBtr0332325; FBpp0304603; FBgn0031871.
DR GeneID; 33971; -.
DR KEGG; dme:Dmel_CG10158; -.
DR UCSC; CG10158-RA; d. melanogaster.
DR CTD; 33971; -.
DR FlyBase; FBgn0031871; Fgop2.
DR VEuPathDB; VectorBase:FBgn0031871; -.
DR eggNOG; ENOG502QSAD; Eukaryota.
DR GeneTree; ENSGT00390000018003; -.
DR HOGENOM; CLU_864003_0_0_1; -.
DR InParanoid; Q9VM65; -.
DR OMA; ELMMQKY; -.
DR OrthoDB; 1368908at2759; -.
DR PhylomeDB; Q9VM65; -.
DR SignaLink; Q9VM65; -.
DR BioGRID-ORCS; 33971; 2 hits in 3 CRISPR screens.
DR GenomeRNAi; 33971; -.
DR PRO; PR:Q9VM65; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0031871; Expressed in testis and 27 other tissues.
DR ExpressionAtlas; Q9VM65; baseline and differential.
DR Genevisible; Q9VM65; DM.
DR GO; GO:0090443; C:FAR/SIN/STRIPAK complex; IDA:FlyBase.
DR GO; GO:0035331; P:negative regulation of hippo signaling; IMP:FlyBase.
DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; HGI:FlyBase.
DR InterPro; IPR008555; SIKE.
DR PANTHER; PTHR12186; PTHR12186; 1.
DR Pfam; PF05769; SIKE; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..315
FT /note="FGFR1 oncogene partner 2 homolog"
FT /id="PRO_0000299057"
FT REGION 201..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 32..99
FT /evidence="ECO:0000255"
FT COILED 156..183
FT /evidence="ECO:0000255"
FT COMPBIAS 238..269
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 315 AA; 35150 MW; A4F07048BEA64EB2 CRC64;
MSNLSVGQII MDAQRMASRV KDLDALGTAL LEEAENNNRL VESLRQYQDD IESLNRISNN
KTNADMVNRI QQQNINSSEI LKENRELKIF IEDYERAMEL MMQKYREHTV SKVLDSKFSF
KELYNERMWQ VIREQREKIN EMAAVMQLAA SVDDGVVQRE LQTISQLRLE NETLRELLQI
SKQYGSSQRP IRESDHLLEE KAVQTDSTAD DSADDLSISG ASVENMNNNS VIQMYSSPEQ
PAKVAGTTNS FNTAPVHSQS ETQAPSVTLE TAPPGEEPLA NDNNNGPAVN TTSAPPPATT
SNESVEDQAT VAPAT
